The moving junction, a key portal to host cell invasion by apicomplexan parasites.

Abstract:

:One defining feature of apicomplexan parasites is their special ability to actively invade host cells. Although rapid, invasion is a complicated process that requires coordinated activities of host cell attachment, protein secretion, and motility by the parasite. Central to this process is the establishment of a structure called moving junction (MJ), which forms a tight connection between invading parasite and host cell membranes through which the parasite passes to enter into the host. Although recognized microscopically for decades, molecular characterization of the MJ was only enabled by the recent discovery of components that make up this multi-protein complex. Exciting progress made during the past few years on both the structure and function of the components of the MJ is reviewed here.

journal_name

Curr Opin Microbiol

authors

Shen B,Sibley LD

doi

10.1016/j.mib.2012.02.007

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

449-55

issue

4

eissn

1369-5274

issn

1879-0364

pii

S1369-5274(12)00023-9

journal_volume

15

pub_type

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