Abstract:
:Membrane shape is functionally linked with many cellular processes. The limiting membrane of vacuoles containing Toxoplasma gondii and Plasmodium apicomplexan parasites lies at the host-parasite interface. This membrane comprises intra-vacuolar and extra-vacuolar tubulo-vesicular deformations, which influence host-parasite cross-talk. Here, underscoring specificities and similarities between the T. gondii and Plasmodium contexts, we present recent findings about vacuolar membrane remodeling and its potential roles in parasite fitness and immune recognition. We review in particular the implication of tubulo-vesicular structures in trapping and/or transporting host and parasite components. Understanding how membrane remodeling influences host-pathogen interactions is expected to be critical in the battle against many intracellular pathogens beyond parasites.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Santi-Rocca J,Blanchard Ndoi
10.1016/j.mib.2017.11.013subject
Has Abstractpub_date
2017-12-01 00:00:00pages
145-151eissn
1369-5274issn
1879-0364pii
S1369-5274(16)30192-8journal_volume
40pub_type
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