The role of giant viruses of amoebas in humans.

abstract：:Motile bacteria seek optimal living habitats by following gradients of attractant and repellent chemicals in their environment. The signaling machinery for these chemotactic behaviors, although assembled from just a few protein components, has extraordinary information-processing capabilities. Escherichia coli, the be...

journal_title：Current opinion in microbiology

authors： Parkinson JS,Ames P,Studdert CA

更新日期：2005-04-01 00:00:00

abstract：:Mast cells (MCs) have been implicated in orchestrating the host's early innate immune and adaptive immune responses in several models of acute bacterial infections. Most of this activity results in early clearance of the bacteria and timely resolution of infection. However, during chronic infections because of the pro...

journal_title：Current opinion in microbiology

authors： Chan CY,St John AL,Abraham SN

更新日期：2012-02-01 00:00:00

abstract：:Recent studies have led to the identification of more than 50 small regulatory RNAs in Escherichia coli. Only a subset of these RNAs has been characterized. However, it is clear that many of the RNAs, such as the MicF, OxyS, DsrA, Spot42 and RyhB RNAs, act by basepairing to activate or repress translation or to destab...

journal_title：Current opinion in microbiology

authors： Storz G,Opdyke JA,Zhang A

更新日期：2004-04-01 00:00:00

abstract：:Successful execution of differentiation programs requires cells to assess multitudes of internal and external cues and respond with appropriate gene expression programs. Here, we review how Bacillus subtilis sporulation network deals with these tasks focusing on the lessons generalizable to other systems. With feedfor...

journal_title：Current opinion in microbiology

authors： Narula J,Fujita M,Igoshin OA

更新日期：2016-12-01 00:00:00

abstract：:Toxin-antitoxin (TA) systems are small genetic modules that are abundant in bacterial genomes. Three types have been described so far, depending on the nature and mode of action of the antitoxin component. While type II systems are surprisingly highly represented because of their capacity to move by horizontal gene tr...

journal_title：Current opinion in microbiology

authors： Van Melderen L

更新日期：2010-12-01 00:00:00

abstract：:In contrast to obligate pathogens opportunistic pathogens such as Aspergillus fumigatus do not need a specific host to propagate or survive. However several characteristics of the saprophytic life-style and the selective pressure encountered in the primary ecological niche contribute to the virulence of A. fumigatus. ...

journal_title：Current opinion in microbiology

authors： Blatzer M,Latgé JP

更新日期：2017-12-01 00:00:00

abstract：:The inexorable rise in cases of tuberculosis worldwide, fuelled by the HIV epidemic, highlights the need for new drugs and particularly those that can shorten the duration of treatment. Clinical trials of existing broad-spectrum agents such as the fluoroquinolone moxifloxacin are proceeding, on the basis of efficacy i...

journal_title：Current opinion in microbiology

authors： Duncan K,Barry CE 3rd

更新日期：2004-10-01 00:00:00

abstract：:The yeast Saccharomyces cerevisiae senses and responds to nutrients by adapting its growth rate and undergoing morphogenic transitions to ensure survival. The Tor pathway is a major integrator of nutrient-derived signals that in coordination with other signaling pathways orchestrates cell growth. Recent advances have ...

journal_title：Current opinion in microbiology

authors： Rohde JR,Bastidas R,Puria R,Cardenas ME

更新日期：2008-04-01 00:00:00

abstract：:Since the publication of the complete genome sequence of Mycobacterium tuberculosis in 1998, there has been a marked intensification and diversification of activities in the field of tuberculosis research. Among the areas that have advanced spectacularly are comparative genomics, functional genomics-notably the study ...

journal_title：Current opinion in microbiology

authors： Domenech P,Barry CE 3rd,Cole ST

更新日期：2001-02-01 00:00:00

abstract：:Bacterial cell division takes place almost entirely below the diffraction limit of light microscopy, making super-resolution microscopy ideally suited to interrogating this process. I review how super-resolution microscopy has advanced our understanding of bacterial cell division. I discuss the mechanistic implication...

journal_title：Current opinion in microbiology

authors： Holden S

更新日期：2018-06-01 00:00:00

abstract：:The opportunistic fungal pathogen Aspergillus fumigatus adapts to iron limitation by upregulation of iron uptake mechanisms including siderophore biosynthesis and downregulation of iron-consuming pathways to spare iron. These metabolic changes depend mainly on the transcription factor HapX. Consistent with the crucial...

journal_title：Current opinion in microbiology

authors： Schrettl M,Haas H

更新日期：2011-08-01 00:00:00

abstract：:Biochemical, serological and microbiological methods have been used to dissect pathogens and identify the components useful for vaccine development. Although successful in many cases, this approach is time-consuming and fails when the pathogens cannot be cultivated in vitro, or when the most abundant antigens are vari...

journal_title：Current opinion in microbiology

authors： Rappuoli R

更新日期：2000-10-01 00:00:00

abstract：:Molecular techniques are providing unprecedented insights into the organismal and functional make-up of natural microbial consortia. Apart from nucleic acid based approaches, community proteomics has the potential to provide a high-resolution representation of genotypic and phenotypic traits of distinct community memb...

journal_title：Current opinion in microbiology

authors： Wilmes P,Bond PL

更新日期：2009-06-01 00:00:00

abstract：:Plasmodium vivax is uniquely restricted to invading reticulocytes, the youngest of red blood cells. Parasite invasion relies on the sequential deployment of multiple parasite invasion ligands. Correct targeting of the host reticulocyte is mediated by two families of invasion ligands: the reticulocyte binding proteins ...

journal_title：Current opinion in microbiology

authors： Kanjee U,Rangel GW,Clark MA,Duraisingh MT

更新日期：2018-12-01 00:00:00

abstract：:In the process of yeast budding, an aged and deteriorated mother cell gives rise to a youthful and pristine daughter cell. This remarkable event offers a tractable model system for identifying factors affecting life expectancy and it has been established that multiple aging factors operate in parallel. Herein, we will...

journal_title：Current opinion in microbiology

authors： Nyström T,Liu B

更新日期：2014-04-01 00:00:00

abstract：:A combination of structural, biochemical and functional studies with the flavivirus tick-borne encephalitis virus has revealed the characteristics of a new class of viral fusion protein, class II, that is unrelated to the class I viral fusion proteins for which influenza virus hemagglutinin is the prototype. New struc...

journal_title：Current opinion in microbiology

authors： Heinz FX,Allison SL

更新日期：2001-08-01 00:00:00

abstract：:Translation of the genome into the proteome is a highly accurate biological process. However, the molecular mechanisms involved in protein synthesis are not error free and downstream protein quality control systems are needed to counteract the negative effects of translational errors (mistranslation) on proteome and c...

journal_title：Current opinion in microbiology

authors： Moura GR,Carreto LC,Santos MA

更新日期：2009-12-01 00:00:00

abstract：:Antibiotic lethality is a complex physiological process, sensitive to external cues. Recent advances using systems approaches have revealed how events downstream of primary target inhibition actively participate in antibiotic death processes. In particular, altered metabolism, translational stress and DNA damage each ...

journal_title：Current opinion in microbiology

authors： Yang JH,Bening SC,Collins JJ

更新日期：2017-10-01 00:00:00

abstract：:Sexual development in filamentous ascomycetes requires mating-type genes to mediate recognition of compatible cell and nuclear types. Characterization of mating-type genes from various fungi shows that they primarily encode transcriptional regulators. Recent studies on mating-type-specific pheromones and internuclear ...

journal_title：Current opinion in microbiology

authors： Shiu PK,Glass NL

更新日期：2000-04-01 00:00:00

abstract：:Following concerns over the potential for insect resistance to insecticidal Bacillus thuringiensis toxins expressed in transgenic plants, there has been recent interest in novel biological insecticides. Over the past year there has been considerable progress in the cloning of several alternative toxin genes from the b...

journal_title：Current opinion in microbiology

authors： ffrench-Constant R,Bowen D

更新日期：1999-06-01 00:00:00

abstract：:Despite the widespread availability of genome sequences and the systematic assignment of individual open reading frames, many of the activities of metabolic enzymes are still veiled. It is difficult to assign biochemical functions to enzymes and uncover the in vivo regulation of their enzymatic activities, but this is...

journal_title：Current opinion in microbiology

authors： Saito N,Ohashi Y,Soga T,Tomita M

更新日期：2010-06-01 00:00:00

abstract：:Single cell genomics (SCG) uncovers hereditary information at the most basic level of biological organization. It is emerging as a powerful complement to cultivation-based and microbial community-focused research approaches. SCG has been instrumental in identifying metabolic features, evolutionary histories and inter-...

journal_title：Current opinion in microbiology

authors： Stepanauskas R

更新日期：2012-10-01 00:00:00

abstract：:Natural products are a rich source of bioactive compounds that have been used successfully in the areas of human health from infectious disease to cancer; however, traditional fermentation-based screening has provided diminishing returns over the last 20-30 years. Solutions to the unmet need of resistant bacterial inf...

journal_title：Current opinion in microbiology

authors： Foulston L

更新日期：2019-10-01 00:00:00

abstract：:Stan Falkow looked at the world with his eyes peering from the outer membrane of a gram-negative bacterium. It was a great vantage point from which to dream about the possible superpowers these organisms might have. He mused about these dreams with his trainees who sometimes found through rigorous scientific explorati...

journal_title：Current opinion in microbiology

authors： Starnbach MN

更新日期：2020-04-01 00:00:00

abstract：:RNA sequencing has emerged as the premier approach to study bacterial transcriptomes. While the earliest published studies analyzed the data qualitatively, the data are readily digitized and lend themselves to quantitative analysis. High-resolution RNA sequence (RNA-seq) data allows transcriptional features (promoters...

journal_title：Current opinion in microbiology

authors： Creecy JP,Conway T

更新日期：2015-02-01 00:00:00

abstract：:N(6)-methyl-adenines can serve as epigenetic signals for interactions between regulatory DNA sequences and regulatory proteins that control cellular functions, such as the initiation of chromosome replication or the expression of specific genes. Several of these genes encode master regulators of the bacterial cell cyc...

journal_title：Current opinion in microbiology

authors： Collier J

更新日期：2009-12-01 00:00:00

abstract：:The ability to control uptake across the mucosa and to protect the gut from harmful substances present in the lumen is defined as intestinal barrier function. Two routes are usually distinguished for transepithelial transport. The paracellular route allows the passage of ions and small molecules and is mainly regulate...

journal_title：Current opinion in microbiology

authors： Barreau F,Hugot JP

更新日期：2014-02-01 00:00:00

abstract：:In Myxococcus xanthus morphogenetic cell movements constitute the basis for the formation of spreading vegetative colonies and fruiting bodies in starving cells. M. xanthus cells move by gliding and gliding motility depends on two polarly localized engines, type IV pili pull cells forward, and slime extruding nozzle-l...

journal_title：Current opinion in microbiology

authors： Søgaard-Andersen L

更新日期：2004-12-01 00:00:00

abstract：:The small nucleotides pppGpp and ppGpp (or (p)ppGpp) are rapidly synthesized in response to nutritional stress. In Escherichia coli, the enzymes RelA and SpoT are triggered by different starvation signals to produce (p)ppGpp. In many Gram-positive bacteria this is carried out by RelA and two small homologs. (p)ppGpp, ...

journal_title：Current opinion in microbiology

authors： Srivatsan A,Wang JD

更新日期：2008-04-01 00:00:00

abstract：:Complete and long-lasting protective immunity against malaria can be achieved through vaccination with invasive live attenuated Plasmodium sporozoites, the motile stage inoculated in the host skin during a mosquito bite. Protective immunity relies primarily on effector CD8+ T cells targeting the parasite in the liver....

journal_title：Current opinion in microbiology

authors： Silvie O,Amino R,Hafalla JC

更新日期：2017-12-01 00:00:00