Abstract：
:Complete and long-lasting protective immunity against malaria can be achieved through vaccination with invasive live attenuated Plasmodium sporozoites, the motile stage inoculated in the host skin during a mosquito bite. Protective immunity relies primarily on effector CD8+ T cells targeting the parasite in the liver. Understanding the tissue-specific features of the immune response is emerging as a vital requirement for understanding protective immunity. The small parasite inoculum, the scarcity of infected cells and the tolerogenic properties of the liver represent hurdles for the establishment of protective immunity in endemic areas. In this review, we discuss recent advances on liver-specific features of immunity including innate recognition of malaria pre-erythrocytic stages, CD8+ T cell interactions with infected hepatocytes, antigen presentation for effective CD8+ T cell responses and generation of liver-resident memory CD8+ T cells. A better understanding of the factors involved in the induction and maintenance of effector CD8+ T cell immunity against malaria pre-erythrocytic stages is crucial for the development of an effective vaccine targeting the initial phase of malaria infection.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Silvie O,Amino R,Hafalla JCdoi
10.1016/j.mib.2017.12.001subject
Has Abstractpub_date
2017-12-01 00:00:00pages
160-167eissn
1369-5274issn
1879-0364pii
S1369-5274(17)30164-9journal_volume
40pub_type
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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abstract：:According to a Pew Research study published in February 2015, there are 37 antibacterial programs currently in clinical trials in the United States. Protein structure-based methods for guiding small molecule design were used in at least 34 of these programs. Typically, this occurred at an early stage (drug discovery a...
journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2013.04.009
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2004.10.003
更新日期：2004-12-01 00:00:00
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
pub_type： 杂志文章
doi：10.1016/s1369-5274(00)00215-0
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/s1369-5274(99)00028-4
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in microbiology
pub_type： 杂志文章
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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abstract：:Translation of the genome into the proteome is a highly accurate biological process. However, the molecular mechanisms involved in protein synthesis are not error free and downstream protein quality control systems are needed to counteract the negative effects of translational errors (mistranslation) on proteome and c...
journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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abstract：:Stan Falkow looked at the world with his eyes peering from the outer membrane of a gram-negative bacterium. It was a great vantage point from which to dream about the possible superpowers these organisms might have. He mused about these dreams with his trainees who sometimes found through rigorous scientific explorati...
journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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abstract：:Signal termination in two-component systems occurs by loss of the phosphoryl group from the response regulator protein. This review explores our current understanding of the structures, catalytic mechanisms and means of regulation of the known families of phosphatases that catalyze response regulator dephosphorylation...
journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2010.01.004
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abstract：:Successful execution of differentiation programs requires cells to assess multitudes of internal and external cues and respond with appropriate gene expression programs. Here, we review how Bacillus subtilis sporulation network deals with these tasks focusing on the lessons generalizable to other systems. With feedfor...
journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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