Metal-homeostasis in the pathobiology of the opportunistic human fungal pathogen Aspergillus fumigatus.

Abstract:

:In contrast to obligate pathogens opportunistic pathogens such as Aspergillus fumigatus do not need a specific host to propagate or survive. However several characteristics of the saprophytic life-style and the selective pressure encountered in the primary ecological niche contribute to the virulence of A. fumigatus. All fungi depend on metals for growth and proliferation, like iron, copper, zinc, manganese or calcium. In the recent past several studies explored the manifold impact of metals modulating virulence of pathogens. Components which might be scarce in the natural environment but also in the host due to nutritional immunity. This review recapitulates molecular constituents of metal ion uptake systems in A. fumigatus, their regulation and their significance at the host-pathogen battlefield.

journal_name

Curr Opin Microbiol

authors

Blatzer M,Latgé JP

doi

10.1016/j.mib.2017.11.015

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

152-159

eissn

1369-5274

issn

1879-0364

pii

S1369-5274(17)30214-X

journal_volume

40

pub_type

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