Striking a balance: fungal commensalism versus pathogenesis.

Abstract:

:The environment is suffused with nearly countless types of fungi, and our immune systems must be tuned to cope with constant exposure to them. In addition, it is becoming increasingly clear that many surfaces of our bodies are colonized with complex populations of fungi (the mycobiome) in the same way that they are colonized with complex populations of bacteria. The immune system must tolerate colonization with commensal fungi but defend against fungal invasion. Truly life-threatening fungal infections are common only when this balance is disrupted through, for example, profound immunosuppression or genetic mutation. Recent studies have begun to shed light on how this balance is established and maintained, and suggest future studies on the role of fungi in homeostatic conditions.

journal_name

Curr Opin Microbiol

authors

Iliev ID,Underhill DM

doi

10.1016/j.mib.2013.05.004

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

366-73

issue

3

eissn

1369-5274

issn

1879-0364

pii

S1369-5274(13)00071-4

journal_volume

16

pub_type

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