Striking a balance: fungal commensalism versus pathogenesis.


:The environment is suffused with nearly countless types of fungi, and our immune systems must be tuned to cope with constant exposure to them. In addition, it is becoming increasingly clear that many surfaces of our bodies are colonized with complex populations of fungi (the mycobiome) in the same way that they are colonized with complex populations of bacteria. The immune system must tolerate colonization with commensal fungi but defend against fungal invasion. Truly life-threatening fungal infections are common only when this balance is disrupted through, for example, profound immunosuppression or genetic mutation. Recent studies have begun to shed light on how this balance is established and maintained, and suggest future studies on the role of fungi in homeostatic conditions.


Curr Opin Microbiol


Iliev ID,Underhill DM




Has Abstract


2013-06-01 00:00:00














  • Bioengineering novel in vitro metabolic pathways using synthetic biology.

    abstract::Huge numbers of enzymes have evolved in nature to function in aqueous environments at moderate temperatures and neutral pH. This gives us, in principle, the unique opportunity to construct multistep reaction systems of considerable catalytic complexity in vitro. However, this opportunity is rarely exploited beyond res...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Meyer A,Pellaux R,Panke S

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  • Host-microbe interactions: Malassezia and human skin.

    abstract::The skin is our first line of defense, protecting us from invasion and evaporation. Its variable structure, changing geography, and complex immune repertoire provide a vast interface for our cutaneous microbial community. Skin is inhabited by many thousands of microbes, but this review focuses on the dominant eukaryot...

    journal_title:Current opinion in microbiology

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    authors: Grice EA,Dawson TL 23⁎Jr

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    authors: Szöör B,Haanstra JR,Gualdrón-López M,Michels PA

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    authors: Monier JM,Demanèche S,Delmont TO,Mathieu A,Vogel TM,Simonet P

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    pub_type: 杂志文章,评审


    authors: Hernández-Rodríguez Y,Momany M

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    pub_type: 杂志文章,评审


    authors: Gogoi M,Datey A,Wilson KT,Chakravortty D

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    pub_type: 杂志文章,评审


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  • Peptidoglycan plasticity in bacteria: emerging variability of the murein sacculus and their associated biological functions.

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    pub_type: 杂志文章,评审


    authors: Cava F,de Pedro MA

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  • Context matters - the complex interplay between resistome genotypes and resistance phenotypes.

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    pub_type: 杂志文章,评审


    authors: Dantas G,Sommer MO

    更新日期:2012-10-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Lacerda TL,Salcedo SP,Gorvel JP

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    pub_type: 杂志文章,评审


    authors: Rodriguez-Valera F,Martin-Cuadrado AB,López-Pérez M

    更新日期:2016-06-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Conlin PL,Chandler JR,Kerr B

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    pub_type: 杂志文章,评审


    authors: Frirdich E,Gaynor EC

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  • Biochemistry of type IV secretion.

    abstract::In the past year, our knowledge of type IV transporters of Gram-negative bacteria has further expanded. Advances include the discovery of additional members of this family of proteins, increased knowledge of the morphologies of type IV transporters, and a better understanding of the mechanisms by which macromolecules ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Burns DL

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  • Exploring novel bioactive compounds from marine microbes.

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    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Zhang L,An R,Wang J,Sun N,Zhang S,Hu J,Kuai J

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    pub_type: 杂志文章,评审


    authors: Loessner MJ

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    pub_type: 杂志文章,评审


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  • How Toxoplasma and malaria parasites defy first, then exploit host autophagic and endocytic pathways for growth.

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


    authors: Silvie O,Amino R,Hafalla JC

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    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Sharma A,Gilbert JA

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  • Cytoskeleton and motor proteins in filamentous fungi.

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    pub_type: 杂志文章,评审


    authors: Xiang X,Plamann M

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  • Recent advances in systems microbiology.

    abstract::Systems biology is a rapidly expanding field fuelled by the 'omics' era coupled to several new technological advances that have increased the precision of data obtainable, meaning that it is now feasible to obtain quantitative measurements from a single cell. The aim of systems biology is to understand the structure, ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Kay E,Wren BW

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  • Silencing of foreign DNA in bacteria.

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    pub_type: 杂志文章,评审


    authors: Ali SS,Xia B,Liu J,Navarre WW

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  • 'Ready made' virulence and 'dual use' virulence factors in pathogenic environmental fungi--the Cryptococcus neoformans paradigm.

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    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Casadevall A,Steenbergen JN,Nosanchuk JD

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  • Coxiella type IV secretion and cellular microbiology.

    abstract::Coxiella burnetii is a widespread zoonotic bacterial pathogen that causes human Q fever. In vivo, Coxiella displays a tropism for mononuclear phagocytes where it participates in biogenesis of a lysosome-like replication compartment to conduct its obligate intracellular lifestyle. Coxiella actively regulates multiple e...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Voth DE,Heinzen RA

    更新日期:2009-02-01 00:00:00

  • Phylogeny of the genus Arenavirus.

    abstract::The family Arenaviridae consists of a unique genus (Arenavirus) that currently comprises 22 viral species, as recognized by the International Committee for Taxonomy of Viruses. Seven newly discovered represent putative new species. Here, our aims were to provide the most comprehensive phylogenetic analysis of members ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Charrel RN,de Lamballerie X,Emonet S

    更新日期:2008-08-01 00:00:00

  • Biofilm dispersion and quorum sensing.

    abstract::Biofilm development and quorum sensing (QS) are closely interconnected processes. Biofilm formation is a cooperative group behaviour that involves bacterial populations living embedded in a self-produced extracellular matrix. QS is a cell-cell communication mechanism that synchronizes gene expression in response to po...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Solano C,Echeverz M,Lasa I

    更新日期:2014-04-01 00:00:00

  • Intestinal organoid/enteroid-based models for Cryptosporidium.

    abstract::Cryptosporidium is a leading cause of diarrhea and death in young children and untreated AIDS patients in resource-poor settings, and of waterborne outbreaks of disease in developed countries. However, there is no consistently effective treatment for vulnerable populations. Progress towards development of therapeutics...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Bhalchandra S,Lamisere H,Ward H

    更新日期:2020-12-01 00:00:00

  • Cell cycle and sporulation in Bacillus subtilis.

    abstract::Recent work on cell division and chromosome orientation and partitioning in Bacillus subtilis has provided insights into cell cycle regulation during growth and development. The cell cycle is an integral part of development and entrance into sporulation is modulated by signals that transmit the status of DNA integrity...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Levin PA,Grossman AD

    更新日期:1998-12-01 00:00:00