Genome archeology leading to the characterization and classification of transport proteins.

Abstract:

:In the study of transmembrane transport, molecular phylogeny provides a reliable guide to protein structure, catalytic and noncatalytic transport mechanisms, mode of energy coupling and substrate specificity. It also allows prediction of the evolutionary history of a transporter family, leading to estimations of its age, source, and route of appearance. Phylogenetic analyses, therefore, provide a rational basis for the characterization and classification of transporters. A universal classification system has been described, based on both function and phylogeny, which has been designed to be applicable to all currently recognized and yet-to-be discovered transport proteins found in living organisms on Earth.

journal_name

Curr Opin Microbiol

authors

Saier MH

doi

10.1016/s1369-5274(99)00016-8

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

555-61

issue

5

eissn

1369-5274

issn

1879-0364

pii

S1369-5274(99)00016-8

journal_volume

2

pub_type

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