Genome archeology leading to the characterization and classification of transport proteins.


:In the study of transmembrane transport, molecular phylogeny provides a reliable guide to protein structure, catalytic and noncatalytic transport mechanisms, mode of energy coupling and substrate specificity. It also allows prediction of the evolutionary history of a transporter family, leading to estimations of its age, source, and route of appearance. Phylogenetic analyses, therefore, provide a rational basis for the characterization and classification of transporters. A universal classification system has been described, based on both function and phylogeny, which has been designed to be applicable to all currently recognized and yet-to-be discovered transport proteins found in living organisms on Earth.


Curr Opin Microbiol


Saier MH




Has Abstract


1999-10-01 00:00:00














  • Molecular basis of pathogenicity in Blastomyces dermatitidis: the importance of adhesion.

    abstract::An understanding of the molecular bases of pathogenicity in Blastomyces dermatitidis and related systemic dimorphic fungi has been limited until recent years. Yeast cells of B. dermatitidis display an adhesion promoting protein termed WI-1. Recent studies entailing homologous gene targeting and mutation of WI-1 have p...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Klein BS

    更新日期:2000-08-01 00:00:00

  • Cytoskeletal proteins participate in conserved viral strategies across kingdoms of life.

    abstract::The discovery of tubulin-like cytoskeletal proteins carried on the genomes of bacteriophages that are actively used for phage propagation during both the lytic and lysogenic cycle have revealed that there at least two ways that viruses can utilize a cytoskeleton; co-opt the host cytoskeleton or bring their own homolog...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Erb ML,Pogliano J

    更新日期:2013-12-01 00:00:00

  • Targeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence.

    abstract::Some RNA virus genomes bear 5'-triphosphates, which can be recognized in the cytoplasm of infected cells by host proteins that mediate anti-viral immunity. Both the innate sensor RIG-I and the interferon-induced IFIT proteins bind to 5'-triphosphate viral RNAs. RIG-I signals for induction of interferons during RNA vir...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Rehwinkel J,Reis e Sousa C

    更新日期:2013-08-01 00:00:00

  • Viral metabolic reprogramming in marine ecosystems.

    abstract::Marine viruses often contain host-derived metabolic genes (i.e., auxiliary metabolic genes; AMGs), which are hypothesized to increase viral replication by augmenting key steps in host metabolism. Currently described AMGs encompass a wide variety of metabolic functions, including amino acid and carbohydrate metabolism,...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Hurwitz BL,U'Ren JM

    更新日期:2016-06-01 00:00:00

  • Epigenetic regulation of the bacterial cell cycle.

    abstract::N(6)-methyl-adenines can serve as epigenetic signals for interactions between regulatory DNA sequences and regulatory proteins that control cellular functions, such as the initiation of chromosome replication or the expression of specific genes. Several of these genes encode master regulators of the bacterial cell cyc...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Collier J

    更新日期:2009-12-01 00:00:00

  • Living in the danger zone: innate immunity to Salmonella.

    abstract::Phagocytic cells, including macrophages, neutrophils and dendritic cells, are critical components of the innate immune response to bacterial pathogens such as Salmonella typhimurium. These cells can have several roles during the early stage of an infection including controlling bacterial replication and producing cyto...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Wick MJ

    更新日期:2004-02-01 00:00:00

  • Genetic analyses of bacterial biofilm formation.

    abstract::Bacterial biofilms are generally described as surface-associated bacterial communities comprising exopolysaccharide-surrounded microcolonies. Interspersed between these microcolonies are water-filled channels that may serve as primitive circulatory systems. Over the past few years, much progress has been made in our u...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Pratt LA,Kolter R

    更新日期:1999-12-01 00:00:00

  • Synthetic microbial communities.

    abstract::While natural microbial communities are composed of a mix of microbes with often unknown functions, the construction of synthetic microbial communities allows for the generation of defined systems with reduced complexity. Used in a top-down approach, synthetic communities serve as model systems to ask questions about ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Grosskopf T,Soyer OS

    更新日期:2014-04-01 00:00:00

  • Advances in understanding the genetic basis of antimalarial drug resistance.

    abstract::The acquisition of drug resistance by Plasmodium falciparum has severely curtailed global efforts to control malaria. Our ability to define resistance has been greatly enhanced by recent advances in Plasmodium genetics and genomics. Sequencing and microarray studies have identified thousands of polymorphisms in the P....

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Ekland EH,Fidock DA

    更新日期:2007-08-01 00:00:00

  • Two-component signal transduction as potential drug targets in pathogenic bacteria.

    abstract::Gene clusters contributing to processes such as cell growth and pathogenicity are often controlled by two-component signal transduction systems (TCSs). Specific inhibitors against TCS systems work differently from conventional antibiotics, and developing them into new drugs that are effective against various drug-resi...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Gotoh Y,Eguchi Y,Watanabe T,Okamoto S,Doi A,Utsumi R

    更新日期:2010-04-01 00:00:00

  • Expanding horizons of cryo-tomography to larger volumes.

    abstract::The three dimensional ultrastructure of cells and tissues comes to light with tomography. There is an inherent tension between representing molecular detail at the highest possible resolution, on one hand, and visualizing spatial relations between large organelles or even neighboring cells in large volumes, on the oth...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Elbaum M

    更新日期:2018-06-01 00:00:00

  • Bacteriophage endolysins--current state of research and applications.

    abstract::Endolysins are phage-encoded enzymes that break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. Their action is tightly regulated by holins, by membrane arrest, and by conversion from their inactive to active state. Recent research has not only revealed the unexpected diversity of t...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Loessner MJ

    更新日期:2005-08-01 00:00:00

  • Two's company: studying interspecies relationships with dual RNA-seq.

    abstract::Organisms do not exist isolated from each other, but constantly interact. Cells can sense the presence of interaction partners by a range of receptors and, via complex regulatory networks, specifically react by changing the expression of many of their genes. Technological advances in next-generation sequencing over th...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Wolf T,Kämmer P,Brunke S,Linde J

    更新日期:2018-04-01 00:00:00

  • Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus.

    abstract::Staphylococcus aureus is a leading cause of hospital-acquired and often persistent infections. A key feature of pathogenic S. aureus is the expression of an array of extracellular matrix-binding proteins. In particular, the fibronectin-binding proteins FnBP-A and FnBP-B afford the pathogen the ability to connect to ce...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Hauck CR,Ohlsen K

    更新日期:2006-02-01 00:00:00

  • Heterocyst development in Anabaena.

    abstract::Many filamentous nitrogen-fixing cyanobacteria protect nitrogenase from oxygen in differentiated cells called heterocysts. Heterocyst development is controlled by the availability of nitrogen compounds in the environment and by intrinsic factors that regulate the frequency and pattern of heterocysts along vegetative c...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Golden JW,Yoon HS

    更新日期:2003-12-01 00:00:00

  • Iron uptake and regulation in Schizosaccharomyces pombe.

    abstract::Schizosaccharomyces pombe is a useful model system for understanding many aspects of eukaryotic cell growth. Studies of S. pombe have identified novel genes that function in the regulation of iron homeostasis. In response to high levels of iron, Fep1 represses the expression of several genes involved in the acquisitio...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Labbé S,Khan MG,Jacques JF

    更新日期:2013-12-01 00:00:00

  • Control of bacterial colonization in the glands and crypts.

    abstract::The epithelial cell layer of the major organs of the mammalian gastrointestinal (GI) tract is extensively invaginated into thousands of gland and crypt structures. These are lined by distinct sets of epithelial cells and may comprise discrete niches. The host maximizes the distance between the epithelial cell layer an...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Yang C,Ottemann KM

    更新日期:2019-02-01 00:00:00

  • The ultimate picture-the combination of live cell superresolution microscopy and single molecule tracking yields highest spatio-temporal resolution.

    abstract::We are witnessing a breathtaking development in light (fluorescence) microscopy, where structures can be resolved down to the size of a ribosome within cells. This has already yielded surprising insight into the subcellular structure of cells, including the smallest cells, bacteria. Moreover, it has become possible to...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Dersch S,Graumann PL

    更新日期:2018-06-01 00:00:00

  • Gene expression in Kinetoplastids.

    abstract::Kinetoplastid parasites adapt to different environments with wide-reaching control of gene expression, but transcription of nuclear protein-coding genes is polycistronic: there is no individual control of transcription initiation. Mature mRNAs are made by co-transcriptional trans splicing and polyadenylation, and comp...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Clayton CE

    更新日期:2016-08-01 00:00:00

  • Metagenomic exploration of antibiotic resistance in soil.

    abstract::The ongoing development of metagenomic approaches is providing the means to explore antibiotic resistance in nature and address questions that could not be answered previously with conventional culture-based strategies. The number of available environmental metagenomic sequence datasets is rapidly expanding and hencef...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Monier JM,Demanèche S,Delmont TO,Mathieu A,Vogel TM,Simonet P

    更新日期:2011-06-01 00:00:00

  • The well-evolved pathogen.

    abstract::Stan Falkow looked at the world with his eyes peering from the outer membrane of a gram-negative bacterium. It was a great vantage point from which to dream about the possible superpowers these organisms might have. He mused about these dreams with his trainees who sometimes found through rigorous scientific explorati...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Starnbach MN

    更新日期:2020-04-01 00:00:00

  • Inter-kingdom signaling: chemical language between bacteria and host.

    abstract::Chemical communication between cells ensures coordination of behavior. In prokaryotes, this chemical communication is usually referred to as quorum sensing, while eukaryotic cells signal through hormones. In the past years, a growing number of reports have shown that bacterial quorum sensing signals, called autoinduce...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Pacheco AR,Sperandio V

    更新日期:2009-04-01 00:00:00

  • Epichloë endophytes: fungal symbionts of grasses.

    abstract::Recent developments have increased our understanding of the evolution of mutualistic associations between Epichloë endophytes and their grass hosts. Most of the asexual species appear to be interspecific hybrids. Although endophytes form compatible associations with their natural hosts, transfers to other hosts elicit...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Scott B

    更新日期:2001-08-01 00:00:00

  • 'Ready made' virulence and 'dual use' virulence factors in pathogenic environmental fungi--the Cryptococcus neoformans paradigm.

    abstract::Environmental pathogenic fungi present a paradox in that they are virulent in animals without requiring animal hosts for replication or survival, a phenomenon we call 'ready-made' virulence. In the human pathogenic fungus Cryptococcus neoformans, the capacity for virulence in animals may originate from environmental s...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Casadevall A,Steenbergen JN,Nosanchuk JD

    更新日期:2003-08-01 00:00:00

  • Microbial community proteomics: elucidating the catalysts and metabolic mechanisms that drive the Earth's biogeochemical cycles.

    abstract::Molecular techniques are providing unprecedented insights into the organismal and functional make-up of natural microbial consortia. Apart from nucleic acid based approaches, community proteomics has the potential to provide a high-resolution representation of genotypic and phenotypic traits of distinct community memb...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Wilmes P,Bond PL

    更新日期:2009-06-01 00:00:00

  • Metal-homeostasis in the pathobiology of the opportunistic human fungal pathogen Aspergillus fumigatus.

    abstract::In contrast to obligate pathogens opportunistic pathogens such as Aspergillus fumigatus do not need a specific host to propagate or survive. However several characteristics of the saprophytic life-style and the selective pressure encountered in the primary ecological niche contribute to the virulence of A. fumigatus. ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Blatzer M,Latgé JP

    更新日期:2017-12-01 00:00:00

  • Cell division is dispensable but not irrelevant in Streptomyces.

    abstract::In part, members of the genus Streptomyces have been studied because they produce many important secondary metabolites with antibiotic activity and for the interest in their relatively elaborate life cycle. These sporulating filamentous bacteria are remarkably synchronous for division and genome segregation in special...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: McCormick JR

    更新日期:2009-12-01 00:00:00

  • Mechanisms of biofilm stimulation by subinhibitory concentrations of antimicrobials.

    abstract::Biofilms are a typical mode of growth for most microorganisms and provide them with a variety of survival benefits. Biofilms can pose medical and industrial challenges due to their increased tolerance of antimicrobials and disinfectants. Exposure of bacteria to subinhibitory concentrations of those compounds can furth...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Ranieri MR,Whitchurch CB,Burrows LL

    更新日期:2018-10-01 00:00:00

  • Adaptive strategies in the double-extremophilic prokaryotes inhabiting soda lakes.

    abstract::Haloalkaliphiles are double extremophilic organisms thriving both at high salinity and alkaline pH. Although numerous haloalkaliphilic representatives have been identified among Archaea and Bacteria over the past 15 years, the adaptations underlying their prosperity at haloalkaline conditions are scarcely known. A mul...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Banciu HL,Muntyan MS

    更新日期:2015-06-01 00:00:00

  • Single-cell reporters for pathogen responses to antimicrobial host attacks.

    abstract::Host-pathogen interactions are often heterogeneous involving individual encounters between host and pathogen cells with diverse molecular mechanisms, response networks, and diverging outcomes. Single-cell reporters can identify the various types of interactions and participating pathogen subsets, help to unravel under...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Roche B,Bumann D

    更新日期:2021-02-01 00:00:00