Abstract：
:Xenogeneic silencing proteins facilitate horizontal gene transfer by silencing expression of AT-rich sequences. By virtue of their activity these proteins serve as master regulators of a variety of important functions including motility, drug resistance, and virulence. Three families of silencers have been identified to date: the H-NS like proteins of Gram-negative bacteria, the MvaT like proteins of Pseudomonacae, and the Lsr2 proteins of Actinobacteria. Structural and biochemical characterization of these proteins have revealed that they share surprising commonalities in mechanism and function despite extensive divergence in both sequence and structure. Here we discuss the mechanisms that underlie the ability of these proteins to selectively target AT-rich DNA and the contradictory data regarding the mode by which H-NS forms nucleoprotein complexes.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Ali SS,Xia B,Liu J,Navarre WWdoi
10.1016/j.mib.2011.12.014subject
Has Abstractpub_date
2012-04-01 00:00:00pages
175-81issue
2eissn
1369-5274issn
1879-0364pii
S1369-5274(11)00223-2journal_volume
15pub_type
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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abstract：:Since the past decades, oligosaccharides are considered for their potential biological activities. To exploit them, it was essential to obtain pure molecules in large amounts. Several strategies were developed to produce specific sugar sequences with specific substitution patterns from land plants and algae polysaccha...
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pub_type： 杂志文章,评审
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更新日期：2009-06-01 00:00:00
