Silencing of foreign DNA in bacteria.

Abstract:

:Xenogeneic silencing proteins facilitate horizontal gene transfer by silencing expression of AT-rich sequences. By virtue of their activity these proteins serve as master regulators of a variety of important functions including motility, drug resistance, and virulence. Three families of silencers have been identified to date: the H-NS like proteins of Gram-negative bacteria, the MvaT like proteins of Pseudomonacae, and the Lsr2 proteins of Actinobacteria. Structural and biochemical characterization of these proteins have revealed that they share surprising commonalities in mechanism and function despite extensive divergence in both sequence and structure. Here we discuss the mechanisms that underlie the ability of these proteins to selectively target AT-rich DNA and the contradictory data regarding the mode by which H-NS forms nucleoprotein complexes.

journal_name

Curr Opin Microbiol

authors

Ali SS,Xia B,Liu J,Navarre WW

doi

10.1016/j.mib.2011.12.014

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

175-81

issue

2

eissn

1369-5274

issn

1879-0364

pii

S1369-5274(11)00223-2

journal_volume

15

pub_type

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