Abstract：
:Infections caused by the apicomplexan parasites Plasmodium and Toxoplasma are wide-spread, life-threatening and therapeutically challenging. These pathogens are obligate intracellular microorganisms that invade mammalian cells by forming a self-made niche, the parasitophorous vacuole that is impervious to host lysosomal fusion. Shortly after invasion, a noncanonical xenophagic pathway resembling LC3-associated phagocytosis is activated by the host cell to control infections. However, Plasmodium and Toxoplasma have elaborated strategies to avoid clearance by the sentinel activities of the host autophagic system. After this initial confrontation, replicating Plasmodium and Toxoplasma adeptly usurp, for their own benefit, host autophagic and endocytic structures by attracting these organelles to their vacuole, likely to access their nutrient-rich content. The pleomorphic function of the autophagy system, from microbial defense to nutrient supply, is reflected by its ambivalent role during the intracellular development of these apicomplexan parasites.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Coppens Idoi
10.1016/j.mib.2017.10.009subject
Has Abstractpub_date
2017-12-01 00:00:00pages
32-39eissn
1369-5274issn
1879-0364pii
S1369-5274(17)30134-0journal_volume
40pub_type
杂志文章,评审abstract：:High-throughput identification of proteins and their accurate partial sequencing by shotgun nanoLC-MS/MS are now feasible for any cellular model at a full genomic scale. Proteogenomics is the integration of these data with the genome. Mining microbial proteomes allows validation of predicted orphan genes and correctio...
journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/s1369-5274(02)00320-x
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2009.09.004
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2016.07.020
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/s1369-5274(99)80004-6
更新日期：1999-02-01 00:00:00
abstract：:The peptidoglycan (PG) sacculus once thought to be just a reinforcing, static and uniform structure, is fast becoming recognized as a dynamic cell constituent involved in every aspect of bacterial physiology. Recent advances showed that in addition to 'classical' tasks-as an essential element to define bacterial shape...
journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2014.01.004
更新日期：2014-04-01 00:00:00
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2018.08.003
更新日期：2018-08-01 00:00:00
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2009.12.008
更新日期：2010-02-01 00:00:00
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2016.03.007
更新日期：2016-06-01 00:00:00
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/S1369-5274(99)80030-7
更新日期：1999-04-01 00:00:00
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2011.12.014
更新日期：2012-04-01 00:00:00
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2018.01.001
更新日期：2018-06-01 00:00:00
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2008.06.001
更新日期：2008-08-01 00:00:00
abstract：:Cryptosporidium is a leading cause of diarrhea and death in young children and untreated AIDS patients in resource-poor settings, and of waterborne outbreaks of disease in developed countries. However, there is no consistently effective treatment for vulnerable populations. Progress towards development of therapeutics...
journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2020.10.002
更新日期：2020-12-01 00:00:00
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2016.08.010
更新日期：2016-12-01 00:00:00
abstract：:Intracellular bacteria in mammalian host cells can either live in a membrane-bound vacuole modified to support bacterial growth, or escape from the primary phagosome into the host cell cytoplasm. Phagosomal escape is best studied in Listeria monocytogenes in which a pore-forming cytolysin and two phospholipases are in...
journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2003.10.004
更新日期：2003-12-01 00:00:00
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2015.09.003
更新日期：2015-10-01 00:00:00
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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更新日期：2015-02-01 00:00:00
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2015.01.011
更新日期：2015-04-01 00:00:00
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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更新日期：2015-02-01 00:00:00
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2020.05.006
更新日期：2020-08-01 00:00:00
abstract：:Organisms do not exist isolated from each other, but constantly interact. Cells can sense the presence of interaction partners by a range of receptors and, via complex regulatory networks, specifically react by changing the expression of many of their genes. Technological advances in next-generation sequencing over th...
journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2017.09.001
更新日期：2018-04-01 00:00:00
abstract：:The Saccharomyces cerevisiae genome sequence, augmented by new data on gene expression and function, continues to yield new findings about eukaryote genome evolution. Analysis of the duplicate gene pairs formed by whole-genome duplication indicates that selection for increased levels of gene expression was a significa...
journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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abstract：:In the last 30 years, significant advances in genetic manipulation tools along with complete genome and transcriptome sequencing have advanced our understanding of the biology of Leishmania parasites and their interplay with the sand fly and mammalian hosts. High-throughput sequencing in association with CRISPR/Cas9 h...
journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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更新日期：2019-12-01 00:00:00
abstract：:In this paper, we discuss recent advances in our knowledge of the dengue virus life cycle based on new structural data of the virus and its proteins. Specifically, we focus on the structure of the pre-membrane protein, prM and its role in virus assembly, the first full-length structure of a multi-domain dengue virus r...
journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2008.06.004
更新日期：2008-08-01 00:00:00
abstract：:In filamentous fungi, the actin cytoskeleton is required for polarity establishment and maintenance at hyphal tips and for formation of a contractile ring at sites of septation. Recently, formins have been identified as Arp (actin-related protein) 2/3-independent nucleators of actin polymerization, and filamentous fun...
journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.mib.2003.10.009
更新日期：2003-12-01 00:00:00
