Biochemistry of type IV secretion.

abstract：:Natural products are a rich source of bioactive compounds that have been used successfully in the areas of human health from infectious disease to cancer; however, traditional fermentation-based screening has provided diminishing returns over the last 20-30 years. Solutions to the unmet need of resistant bacterial inf...

journal_title：Current opinion in microbiology

authors： Foulston L

更新日期：2019-10-01 00:00:00

abstract：:In part, members of the genus Streptomyces have been studied because they produce many important secondary metabolites with antibiotic activity and for the interest in their relatively elaborate life cycle. These sporulating filamentous bacteria are remarkably synchronous for division and genome segregation in special...

journal_title：Current opinion in microbiology

authors： McCormick JR

更新日期：2009-12-01 00:00:00

abstract：:RNA sequencing has emerged as the premier approach to study bacterial transcriptomes. While the earliest published studies analyzed the data qualitatively, the data are readily digitized and lend themselves to quantitative analysis. High-resolution RNA sequence (RNA-seq) data allows transcriptional features (promoters...

journal_title：Current opinion in microbiology

authors： Creecy JP,Conway T

更新日期：2015-02-01 00:00:00

abstract：:Membrane shape is functionally linked with many cellular processes. The limiting membrane of vacuoles containing Toxoplasma gondii and Plasmodium apicomplexan parasites lies at the host-parasite interface. This membrane comprises intra-vacuolar and extra-vacuolar tubulo-vesicular deformations, which influence host-par...

journal_title：Current opinion in microbiology

authors： Santi-Rocca J,Blanchard N

更新日期：2017-12-01 00:00:00

abstract：:Inflammasomes - molecular platforms for caspase-1 activation - have emerged as common hubs for a number of pathways that detect and respond to bacterial pathogens. Caspase-1 activation results in the secretion of bioactive IL-1β and IL-18 and pyroptosis, and thus launches a systemic immune and inflammatory response. I...

journal_title：Current opinion in microbiology

authors： Eldridge MJ,Shenoy AR

更新日期：2015-02-01 00:00:00

abstract：:In the process of yeast budding, an aged and deteriorated mother cell gives rise to a youthful and pristine daughter cell. This remarkable event offers a tractable model system for identifying factors affecting life expectancy and it has been established that multiple aging factors operate in parallel. Herein, we will...

journal_title：Current opinion in microbiology

authors： Nyström T,Liu B

更新日期：2014-04-01 00:00:00

abstract：:Sensing its changing environment is key for Vibrio cholerae when making the transition from an aquatic lifestyle to one more suited to a human host. An inverse correlation between motility and virulence gene expression has been reported, with the NADH : ubiquinone oxidoreductase system which powers motility by generat...

journal_title：Current opinion in microbiology

authors： Krukonis ES,DiRita VJ

更新日期：2003-04-01 00:00:00

abstract：:Stan Falkow looked at the world with his eyes peering from the outer membrane of a gram-negative bacterium. It was a great vantage point from which to dream about the possible superpowers these organisms might have. He mused about these dreams with his trainees who sometimes found through rigorous scientific explorati...

journal_title：Current opinion in microbiology

authors： Starnbach MN

更新日期：2020-04-01 00:00:00

abstract：:Much of what we know about cytokinesis in bacteria has come from studies with Escherichia coli, and efforts to comprehensively understand this fundamental process in this organism continue to intensify. Major recent advances include in vitro assembly of a membrane-tethered version of FtsZ into contractile rings in lip...

journal_title：Current opinion in microbiology

authors： de Boer PA

更新日期：2010-12-01 00:00:00

abstract：:Candida albicans is a regular member of the intestinal microbiota in the majority of the human population. This underscores C. albicans' adaptation to life in the intestine without inducing competitive interactions with other microbes, or immune responses detrimental to its survival. However, specific conditions such ...

journal_title：Current opinion in microbiology

authors： Kumamoto CA,Gresnigt MS,Hube B

更新日期：2020-08-01 00:00:00

abstract：:Despite the widespread availability of genome sequences and the systematic assignment of individual open reading frames, many of the activities of metabolic enzymes are still veiled. It is difficult to assign biochemical functions to enzymes and uncover the in vivo regulation of their enzymatic activities, but this is...

journal_title：Current opinion in microbiology

authors： Saito N,Ohashi Y,Soga T,Tomita M

更新日期：2010-06-01 00:00:00

abstract：:Motile bacteria seek optimal living habitats by following gradients of attractant and repellent chemicals in their environment. The signaling machinery for these chemotactic behaviors, although assembled from just a few protein components, has extraordinary information-processing capabilities. Escherichia coli, the be...

journal_title：Current opinion in microbiology

authors： Parkinson JS,Ames P,Studdert CA

更新日期：2005-04-01 00:00:00

abstract：:The emerging human pathogen Bartonella henselae has the remarkable capacity to colonise vascular tissues and to stimulate vasoproliferative tumour growth. Although the molecular principle of bacterium-induced neovascularisation (angiogenesis) is still unclear, recent studies have indicated a novel mechanism of endothe...

journal_title：Current opinion in microbiology

authors： Dehio C

更新日期：1999-02-01 00:00:00

abstract：:Wild Escherichia coli are superbly adapted to survive in the intestines of their mammalian hosts and in the environment. E. coli K12 derivative (MG1655) encodes 4288 potential genes that provide the background genetic framework of this species. Particular E. coli clonal types encode additional chromosomal and extrachr...

journal_title：Current opinion in microbiology

authors： Dougan G,Haque A,Pickard D,Frankel G,O'Goara P,Wain J

更新日期：2001-02-01 00:00:00

abstract：:In response to starvation, myxobacteria build multicellular fruiting bodies that contain many thousands of cells and that have particular species-specific shapes. To coordinate fruiting body development, the myxobacterial cells signal to each other. The timing of and cellular responses to these signals help to give fo...

journal_title：Current opinion in microbiology

authors： Kaiser D

更新日期：1998-12-01 00:00:00

abstract：:The continued evolution of antimicrobial resistance in the hospital and more recently in the community threatens to seriously compromise our ability to treat serious infections. The major success of the seven-valent Streptococcus pneumoniae vaccine at reducing both infection and resistance has been followed by the eme...

journal_title：Current opinion in microbiology

authors： Rice LB

更新日期：2009-10-01 00:00:00

abstract：:Chemical communication between cells ensures coordination of behavior. In prokaryotes, this chemical communication is usually referred to as quorum sensing, while eukaryotic cells signal through hormones. In the past years, a growing number of reports have shown that bacterial quorum sensing signals, called autoinduce...

journal_title：Current opinion in microbiology

authors： Pacheco AR,Sperandio V

更新日期：2009-04-01 00:00:00

abstract：:Wastewater bioreactors have been used to treat domestic and industrial waste for nearly a century. Development of molecular tools such as PCR and DNA microarrays have enabled identification and characterization of some of the microbes in these bioreactors; however, molecular characterization of the microbes is still i...

journal_title：Current opinion in microbiology

authors： Bramucci M,Nagarajan V

更新日期：2006-06-01 00:00:00

abstract：:An understanding of the molecular bases of pathogenicity in Blastomyces dermatitidis and related systemic dimorphic fungi has been limited until recent years. Yeast cells of B. dermatitidis display an adhesion promoting protein termed WI-1. Recent studies entailing homologous gene targeting and mutation of WI-1 have p...

journal_title：Current opinion in microbiology

authors： Klein BS

更新日期：2000-08-01 00:00:00

abstract：:The recent discovery of binding protein dependent secondary transporters and the ever-growing family of membrane potential generating secondary transporters emphasize the diversity of transport systems in both the mechanistical and physiological sense. The vast amount of data on the lactose permease is now beginning t...

journal_title：Current opinion in microbiology

authors： Lolkema JS,Poolman B,Konings WN

更新日期：1998-04-01 00:00:00

abstract：:Natural prokaryotic populations are composed of multiple clonal lineages that are different in their core genomes in a range that varies typically between 95 and 100% nucleotide identity. Each clonal lineage also carries a complement of not shared flexible genes that can be very large. The compounded flexible genome p...

journal_title：Current opinion in microbiology

authors： Rodriguez-Valera F,Martin-Cuadrado AB,López-Pérez M

更新日期：2016-06-01 00:00:00

abstract：:Recent work has shown that Immunoglobulin-like (Ig-like) domains occur frequently on the surface of tailed dsDNA bacteriophages. Several of these Ig-like domains are added to bacteriophage structural proteins via programmed ribosomal frameshifts, and their evolutionary patterns suggest that they can be exchanged by ho...

journal_title：Current opinion in microbiology

authors： Fraser JS,Maxwell KL,Davidson AR

更新日期：2007-08-01 00:00:00

abstract：:Haloalkaliphiles are double extremophilic organisms thriving both at high salinity and alkaline pH. Although numerous haloalkaliphilic representatives have been identified among Archaea and Bacteria over the past 15 years, the adaptations underlying their prosperity at haloalkaline conditions are scarcely known. A mul...

journal_title：Current opinion in microbiology

authors： Banciu HL,Muntyan MS

更新日期：2015-06-01 00:00:00

abstract：:We have now complete genome sequences of several pairs of closely related prokaryotes (conspecific strains or congeneric species). Surprisingly, even strains of the same species can differ by as much as 20% in gene content. Conceptual and methodological approaches for dealing with such diversity are now being develope...

journal_title：Current opinion in microbiology

authors： Boucher Y,Nesbø CL,Doolittle WF

更新日期：2001-06-01 00:00:00

abstract：:Dectin-1 is an innate immune pattern recognition receptor (PRR) that, through its ability to bind β-glucans, is involved in the recognition of several pathogenic fungi. Dectin-1 can stimulate a variety of cellular responses via the Syk/CARD9 signalling pathway, including phagocytosis, cytokine production and the respi...

journal_title：Current opinion in microbiology

authors： Drummond RA,Brown GD

更新日期：2011-08-01 00:00:00

abstract：:High-throughput identification of proteins and their accurate partial sequencing by shotgun nanoLC-MS/MS are now feasible for any cellular model at a full genomic scale. Proteogenomics is the integration of these data with the genome. Mining microbial proteomes allows validation of predicted orphan genes and correctio...

journal_title：Current opinion in microbiology

authors： Armengaud J

更新日期：2009-06-01 00:00:00

abstract：:The review highlights the dual role that the conserved master regulator FoxO has in aging by coordinating both stem cell proliferation and antimicrobial peptides, effector molecules of the innate immune system. As observed in non-senescent Hydra, continuously high activity of the transcription factor FoxO contributes ...

journal_title：Current opinion in microbiology

authors： Mortzfeld BM,Bosch TC

更新日期：2017-08-01 00:00:00

abstract：:Endosymbiotic theory goes back over 100 years. It explains the similarity of chloroplasts and mitochondria to free-living prokaryotes by suggesting that the organelles arose from prokaryotes through (endo)symbiosis. Gene trees provide important evidence in favour of symbiotic theory at a coarse-grained level, but the ...

journal_title：Current opinion in microbiology

authors： Zimorski V,Ku C,Martin WF,Gould SB

更新日期：2014-12-01 00:00:00

abstract：:Complete and long-lasting protective immunity against malaria can be achieved through vaccination with invasive live attenuated Plasmodium sporozoites, the motile stage inoculated in the host skin during a mosquito bite. Protective immunity relies primarily on effector CD8+ T cells targeting the parasite in the liver....

journal_title：Current opinion in microbiology

authors： Silvie O,Amino R,Hafalla JC

更新日期：2017-12-01 00:00:00

abstract：:In the study of transmembrane transport, molecular phylogeny provides a reliable guide to protein structure, catalytic and noncatalytic transport mechanisms, mode of energy coupling and substrate specificity. It also allows prediction of the evolutionary history of a transporter family, leading to estimations of its a...

journal_title：Current opinion in microbiology

authors： Saier MH

更新日期：1999-10-01 00:00:00