Molecular basis of pathogenicity in Blastomyces dermatitidis: the importance of adhesion.


:An understanding of the molecular bases of pathogenicity in Blastomyces dermatitidis and related systemic dimorphic fungi has been limited until recent years. Yeast cells of B. dermatitidis display an adhesion promoting protein termed WI-1. Recent studies entailing homologous gene targeting and mutation of WI-1 have provided null mutants at this locus and demonstrated the crucial role of the WI-1 adhesin in pathogenesis of blastomycosis. Ongoing studies are pointing to a link between phase-specific expression of WI-1 and the observation that transition to yeast cells is essential for the acquisition of pathogenicity by B. dermatitidis. Recombinant attenuated yeast that lack WI-1 are serving as invaluable tools for induction of vaccine resistance and are pointing to new insights about adaptive immunity to B. dermatitidis.


Curr Opin Microbiol


Klein BS




Has Abstract


2000-08-01 00:00:00














  • Phylogeny of the genus Arenavirus.

    abstract::The family Arenaviridae consists of a unique genus (Arenavirus) that currently comprises 22 viral species, as recognized by the International Committee for Taxonomy of Viruses. Seven newly discovered represent putative new species. Here, our aims were to provide the most comprehensive phylogenetic analysis of members ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Charrel RN,de Lamballerie X,Emonet S

    更新日期:2008-08-01 00:00:00

  • Genome archeology leading to the characterization and classification of transport proteins.

    abstract::In the study of transmembrane transport, molecular phylogeny provides a reliable guide to protein structure, catalytic and noncatalytic transport mechanisms, mode of energy coupling and substrate specificity. It also allows prediction of the evolutionary history of a transporter family, leading to estimations of its a...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章


    authors: Saier MH

    更新日期:1999-10-01 00:00:00

  • The role of giant viruses of amoebas in humans.

    abstract::Since 2003, dozens of giant viruses that infect amoebas (GVA), including mimiviruses and marseilleviruses, have been discovered. These giants appear to be common in our biosphere. From the onset, their presence and possible pathogenic role in humans have been serendipitously observed or investigated using a broad rang...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Colson P,Aherfi S,La Scola B,Raoult D

    更新日期:2016-06-01 00:00:00

  • Heterocyst development in Anabaena.

    abstract::Many filamentous nitrogen-fixing cyanobacteria protect nitrogenase from oxygen in differentiated cells called heterocysts. Heterocyst development is controlled by the availability of nitrogen compounds in the environment and by intrinsic factors that regulate the frequency and pattern of heterocysts along vegetative c...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Golden JW,Yoon HS

    更新日期:2003-12-01 00:00:00

  • Photorhabdus toxins: novel biological insecticides.

    abstract::Following concerns over the potential for insect resistance to insecticidal Bacillus thuringiensis toxins expressed in transgenic plants, there has been recent interest in novel biological insecticides. Over the past year there has been considerable progress in the cloning of several alternative toxin genes from the b...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: ffrench-Constant R,Bowen D

    更新日期:1999-06-01 00:00:00

  • From motility to virulence: Sensing and responding to environmental signals in Vibrio cholerae.

    abstract::Sensing its changing environment is key for Vibrio cholerae when making the transition from an aquatic lifestyle to one more suited to a human host. An inverse correlation between motility and virulence gene expression has been reported, with the NADH : ubiquinone oxidoreductase system which powers motility by generat...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Krukonis ES,DiRita VJ

    更新日期:2003-04-01 00:00:00

  • Yersinia versus host immunity: how a pathogen evades or triggers a protective response.

    abstract::The human pathogenic Yersinia species cause diseases that represent a significant source of morbidity and mortality. Despite this, specific mechanisms underlying Yersinia pathogenesis and protective host responses remain poorly understood. Recent studies have shown that Yersinia disrupt cell death pathways, perturb in...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Chung LK,Bliska JB

    更新日期:2016-02-01 00:00:00

  • Epigenetic regulation of the bacterial cell cycle.

    abstract::N(6)-methyl-adenines can serve as epigenetic signals for interactions between regulatory DNA sequences and regulatory proteins that control cellular functions, such as the initiation of chromosome replication or the expression of specific genes. Several of these genes encode master regulators of the bacterial cell cyc...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Collier J

    更新日期:2009-12-01 00:00:00

  • Giants among larges: how gigantism impacts giant virus entry into amoebae.

    abstract::The proposed order Megavirales comprises the nucleocytoplasmic large DNA viruses (NCLDV), infecting a wide range of hosts. Over time, they co-evolved with different host cells, developing various strategies to penetrate them. Mimiviruses and other giant viruses enter cells through phagocytosis, while Marseillevirus an...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Rodrigues RAL,Abrahão JS,Drumond BP,Kroon EG

    更新日期:2016-06-01 00:00:00

  • Peptidoglycan hydrolases, bacterial shape, and pathogenesis.

    abstract::Bacterial shape has always been hypothesized to play an important role in the biology of a species and in the ability of certain bacteria to influence human health. The recent discovery of peptidoglycan hydrolases that modulate shape has now allowed this hypothesis to be addressed directly. Genetic, biochemical, and p...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Frirdich E,Gaynor EC

    更新日期:2013-12-01 00:00:00

  • Bacterial endosymbionts in animals.

    abstract::Molecular phylogenetic studies reveal that many endosymbioses between bacteria and invertebrate hosts result from ancient infections followed by strict vertical transmission within host lineages. Endosymbionts display a distinctive constellation of genetic properties including AT-biased base composition, accelerated s...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Moran NA,Baumann P

    更新日期:2000-06-01 00:00:00

  • Living in the danger zone: innate immunity to Salmonella.

    abstract::Phagocytic cells, including macrophages, neutrophils and dendritic cells, are critical components of the innate immune response to bacterial pathogens such as Salmonella typhimurium. These cells can have several roles during the early stage of an infection including controlling bacterial replication and producing cyto...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Wick MJ

    更新日期:2004-02-01 00:00:00

  • The machinery for flavivirus fusion with host cell membranes.

    abstract::A combination of structural, biochemical and functional studies with the flavivirus tick-borne encephalitis virus has revealed the characteristics of a new class of viral fusion protein, class II, that is unrelated to the class I viral fusion proteins for which influenza virus hemagglutinin is the prototype. New struc...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Heinz FX,Allison SL

    更新日期:2001-08-01 00:00:00

  • A perfect genome annotation is within reach with the proteomics and genomics alliance.

    abstract::High-throughput identification of proteins and their accurate partial sequencing by shotgun nanoLC-MS/MS are now feasible for any cellular model at a full genomic scale. Proteogenomics is the integration of these data with the genome. Mining microbial proteomes allows validation of predicted orphan genes and correctio...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Armengaud J

    更新日期:2009-06-01 00:00:00

  • Microbial genomes: dealing with diversity.

    abstract::We have now complete genome sequences of several pairs of closely related prokaryotes (conspecific strains or congeneric species). Surprisingly, even strains of the same species can differ by as much as 20% in gene content. Conceptual and methodological approaches for dealing with such diversity are now being develope...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Boucher Y,Nesbø CL,Doolittle WF

    更新日期:2001-06-01 00:00:00

  • Auxiliary phosphatases in two-component signal transduction.

    abstract::Signal termination in two-component systems occurs by loss of the phosphoryl group from the response regulator protein. This review explores our current understanding of the structures, catalytic mechanisms and means of regulation of the known families of phosphatases that catalyze response regulator dephosphorylation...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Silversmith RE

    更新日期:2010-04-01 00:00:00

  • Virome genomics: a tool for defining the human virome.

    abstract::High throughput, deep sequencing assays are powerful tools for gaining insights into virus-host interactions. Sequencing assays can discover novel viruses and describe the genomes of novel and known viruses. Genomic information can predict viral proteins that can be characterized, describe important genes in the host ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Wylie KM,Weinstock GM,Storch GA

    更新日期:2013-08-01 00:00:00

  • Regulatory small RNAs from the 3' regions of bacterial mRNAs.

    abstract::Most studies of small regulatory RNAs in bacteria have focussed on conserved transcripts in intergenic regions. However, several recent developments including single-nucleotide resolution transcriptome profiling by RNA-seq and increased knowledge of the cellular targets of the RNA chaperone Hfq suggest that the bacter...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Miyakoshi M,Chao Y,Vogel J

    更新日期:2015-04-01 00:00:00

  • Genomic sequencing of single microbial cells from environmental samples.

    abstract::Recently developed techniques allow genomic DNA sequencing from single microbial cells [Lasken RS: Single-cell genomic sequencing using multiple displacement amplification. Curr Opin Microbiol 2007, 10:510-516]. Here, we focus on research strategies for putting these methods into practice in the laboratory setting. An...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Ishoey T,Woyke T,Stepanauskas R,Novotny M,Lasken RS

    更新日期:2008-06-01 00:00:00

  • Anaplasma phagocytophilum and Ehrlichia chaffeensis type IV secretion and Ank proteins.

    abstract::The obligatory intracellular bacterial pathogens Anaplasma and Ehrlichia infect leukocytes by hijacking host-cell components and processes. The type IV secretion system is up-regulated during infection. Among type IV secretion candidate substrates, an ankyrin repeat protein of Anaplasma phagocytophilum, AnkA, is deliv...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Rikihisa Y,Lin M

    更新日期:2010-02-01 00:00:00

  • Non-coding RNA and the complex regulation of the trypanosome life cycle.

    abstract::The protozoan parasite Trypanosoma brucei is the causative agent of African sleeping sickness and the wasting disease, nagana, in cattle. The parasite is transmitted to the mammalian host by the bite of a tsetse fly. These parasites lack transcriptional regulation, and their gene expression is mainly regulated post-tr...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Michaeli S

    更新日期:2014-08-01 00:00:00

  • Genomic analysis using conditional phenotypes generated by antisense RNA.

    abstract::Antisense technology has been widely used to regulate gene expression. A tetracycline (tet)-regulated antisense-RNA-expressing system has been developed and used to downregulate chromosomally derived genes expressed in Staphylococcus aureus. This downregulation subsequently provides an evaluation of the virulence fact...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Yin D,Ji Y

    更新日期:2002-06-01 00:00:00

  • Targeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence.

    abstract::Some RNA virus genomes bear 5'-triphosphates, which can be recognized in the cytoplasm of infected cells by host proteins that mediate anti-viral immunity. Both the innate sensor RIG-I and the interferon-induced IFIT proteins bind to 5'-triphosphate viral RNAs. RIG-I signals for induction of interferons during RNA vir...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Rehwinkel J,Reis e Sousa C

    更新日期:2013-08-01 00:00:00

  • A phagosome of one's own: a microbial guide to life in the macrophage.

    abstract::Macrophages protect their host by engulfing foreign bodies within phagosomes that rapidly develop into microbicidal organelles. Numerous pathogens, such as species of Toxoplasma, Leishmania, Mycobacterium, Salmonella and Legionella, thrive in human macrophages, sometimes with disastrous effects. Defining the survival ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Amer AO,Swanson MS

    更新日期:2002-02-01 00:00:00

  • Immune control of phagosomal bacteria by p47 GTPases.

    abstract::Sequestered from the action of complement, antibody and lytic peptides, phagosomal pathogens pose a unique problem for the innate immune system both in terms of detection and disposal. An immunologically induced 47-kDa (p47) GTPase family recruited to nascent phagosomes (PGs) has provided new insights into how vertebr...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: MacMicking JD

    更新日期:2005-02-01 00:00:00

  • The role of 'eat-me' signals and autophagy cargo receptors in innate immunity.

    abstract::Selective autophagy is an important effector mechanism of cell autonomous immunity, in particular against invasive bacterial species. Anti-bacterial autophagy is activated by rupture of bacteria-containing vacuoles and exposure of bacteria to the cytosol. The autophagy cargo receptors p62, NDP52 and Optineurin detect ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Boyle KB,Randow F

    更新日期:2013-06-01 00:00:00

  • Unveiling cellular biochemical reactions via metabolomics-driven approaches.

    abstract::Despite the widespread availability of genome sequences and the systematic assignment of individual open reading frames, many of the activities of metabolic enzymes are still veiled. It is difficult to assign biochemical functions to enzymes and uncover the in vivo regulation of their enzymatic activities, but this is...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Saito N,Ohashi Y,Soga T,Tomita M

    更新日期:2010-06-01 00:00:00

  • Yeast genome evolution in the post-genome era.

    abstract::The Saccharomyces cerevisiae genome sequence, augmented by new data on gene expression and function, continues to yield new findings about eukaryote genome evolution. Analysis of the duplicate gene pairs formed by whole-genome duplication indicates that selection for increased levels of gene expression was a significa...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Seoighe C,Wolfe KH

    更新日期:1999-10-01 00:00:00

  • Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus.

    abstract::Staphylococcus aureus is a leading cause of hospital-acquired and often persistent infections. A key feature of pathogenic S. aureus is the expression of an array of extracellular matrix-binding proteins. In particular, the fibronectin-binding proteins FnBP-A and FnBP-B afford the pathogen the ability to connect to ce...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Hauck CR,Ohlsen K

    更新日期:2006-02-01 00:00:00

  • Pneumococcal conjugate vaccines - implications for community antibiotic prescribing.

    abstract::Infections caused by Streptococcus pneumoniae are a major cause of morbidity and mortality in the pediatric population worldwide. Development of increasing resistance to multiple classes of antibiotics is making treatment of infections caused by this organism much more difficult. In order to prevent disease, a 23-vale...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Tan TQ

    更新日期:2000-10-01 00:00:00