Molecular basis of pathogenicity in Blastomyces dermatitidis: the importance of adhesion.

abstract：:The family Arenaviridae consists of a unique genus (Arenavirus) that currently comprises 22 viral species, as recognized by the International Committee for Taxonomy of Viruses. Seven newly discovered represent putative new species. Here, our aims were to provide the most comprehensive phylogenetic analysis of members ...

journal_title：Current opinion in microbiology

authors： Charrel RN,de Lamballerie X,Emonet S

更新日期：2008-08-01 00:00:00

abstract：:In the study of transmembrane transport, molecular phylogeny provides a reliable guide to protein structure, catalytic and noncatalytic transport mechanisms, mode of energy coupling and substrate specificity. It also allows prediction of the evolutionary history of a transporter family, leading to estimations of its a...

journal_title：Current opinion in microbiology

authors： Saier MH

更新日期：1999-10-01 00:00:00

abstract：:Since 2003, dozens of giant viruses that infect amoebas (GVA), including mimiviruses and marseilleviruses, have been discovered. These giants appear to be common in our biosphere. From the onset, their presence and possible pathogenic role in humans have been serendipitously observed or investigated using a broad rang...

journal_title：Current opinion in microbiology

authors： Colson P,Aherfi S,La Scola B,Raoult D

更新日期：2016-06-01 00:00:00

abstract：:Many filamentous nitrogen-fixing cyanobacteria protect nitrogenase from oxygen in differentiated cells called heterocysts. Heterocyst development is controlled by the availability of nitrogen compounds in the environment and by intrinsic factors that regulate the frequency and pattern of heterocysts along vegetative c...

journal_title：Current opinion in microbiology

authors： Golden JW,Yoon HS

更新日期：2003-12-01 00:00:00

abstract：:Following concerns over the potential for insect resistance to insecticidal Bacillus thuringiensis toxins expressed in transgenic plants, there has been recent interest in novel biological insecticides. Over the past year there has been considerable progress in the cloning of several alternative toxin genes from the b...

journal_title：Current opinion in microbiology

authors： ffrench-Constant R,Bowen D

更新日期：1999-06-01 00:00:00

abstract：:Sensing its changing environment is key for Vibrio cholerae when making the transition from an aquatic lifestyle to one more suited to a human host. An inverse correlation between motility and virulence gene expression has been reported, with the NADH : ubiquinone oxidoreductase system which powers motility by generat...

journal_title：Current opinion in microbiology

authors： Krukonis ES,DiRita VJ

更新日期：2003-04-01 00:00:00

abstract：:The human pathogenic Yersinia species cause diseases that represent a significant source of morbidity and mortality. Despite this, specific mechanisms underlying Yersinia pathogenesis and protective host responses remain poorly understood. Recent studies have shown that Yersinia disrupt cell death pathways, perturb in...

journal_title：Current opinion in microbiology

authors： Chung LK,Bliska JB

更新日期：2016-02-01 00:00:00

abstract：:N(6)-methyl-adenines can serve as epigenetic signals for interactions between regulatory DNA sequences and regulatory proteins that control cellular functions, such as the initiation of chromosome replication or the expression of specific genes. Several of these genes encode master regulators of the bacterial cell cyc...

journal_title：Current opinion in microbiology

authors： Collier J

更新日期：2009-12-01 00:00:00

abstract：:The proposed order Megavirales comprises the nucleocytoplasmic large DNA viruses (NCLDV), infecting a wide range of hosts. Over time, they co-evolved with different host cells, developing various strategies to penetrate them. Mimiviruses and other giant viruses enter cells through phagocytosis, while Marseillevirus an...

journal_title：Current opinion in microbiology

authors： Rodrigues RAL,Abrahão JS,Drumond BP,Kroon EG

更新日期：2016-06-01 00:00:00

abstract：:Bacterial shape has always been hypothesized to play an important role in the biology of a species and in the ability of certain bacteria to influence human health. The recent discovery of peptidoglycan hydrolases that modulate shape has now allowed this hypothesis to be addressed directly. Genetic, biochemical, and p...

journal_title：Current opinion in microbiology

authors： Frirdich E,Gaynor EC

更新日期：2013-12-01 00:00:00

abstract：:Molecular phylogenetic studies reveal that many endosymbioses between bacteria and invertebrate hosts result from ancient infections followed by strict vertical transmission within host lineages. Endosymbionts display a distinctive constellation of genetic properties including AT-biased base composition, accelerated s...

journal_title：Current opinion in microbiology

authors： Moran NA,Baumann P

更新日期：2000-06-01 00:00:00

abstract：:Phagocytic cells, including macrophages, neutrophils and dendritic cells, are critical components of the innate immune response to bacterial pathogens such as Salmonella typhimurium. These cells can have several roles during the early stage of an infection including controlling bacterial replication and producing cyto...

journal_title：Current opinion in microbiology

authors： Wick MJ

更新日期：2004-02-01 00:00:00

abstract：:A combination of structural, biochemical and functional studies with the flavivirus tick-borne encephalitis virus has revealed the characteristics of a new class of viral fusion protein, class II, that is unrelated to the class I viral fusion proteins for which influenza virus hemagglutinin is the prototype. New struc...

journal_title：Current opinion in microbiology

authors： Heinz FX,Allison SL

更新日期：2001-08-01 00:00:00

abstract：:High-throughput identification of proteins and their accurate partial sequencing by shotgun nanoLC-MS/MS are now feasible for any cellular model at a full genomic scale. Proteogenomics is the integration of these data with the genome. Mining microbial proteomes allows validation of predicted orphan genes and correctio...

journal_title：Current opinion in microbiology

authors： Armengaud J

更新日期：2009-06-01 00:00:00

abstract：:We have now complete genome sequences of several pairs of closely related prokaryotes (conspecific strains or congeneric species). Surprisingly, even strains of the same species can differ by as much as 20% in gene content. Conceptual and methodological approaches for dealing with such diversity are now being develope...

journal_title：Current opinion in microbiology

authors： Boucher Y,Nesbø CL,Doolittle WF

更新日期：2001-06-01 00:00:00

abstract：:Signal termination in two-component systems occurs by loss of the phosphoryl group from the response regulator protein. This review explores our current understanding of the structures, catalytic mechanisms and means of regulation of the known families of phosphatases that catalyze response regulator dephosphorylation...

journal_title：Current opinion in microbiology

authors： Silversmith RE

更新日期：2010-04-01 00:00:00

abstract：:High throughput, deep sequencing assays are powerful tools for gaining insights into virus-host interactions. Sequencing assays can discover novel viruses and describe the genomes of novel and known viruses. Genomic information can predict viral proteins that can be characterized, describe important genes in the host ...

journal_title：Current opinion in microbiology

authors： Wylie KM,Weinstock GM,Storch GA

更新日期：2013-08-01 00:00:00

abstract：:Most studies of small regulatory RNAs in bacteria have focussed on conserved transcripts in intergenic regions. However, several recent developments including single-nucleotide resolution transcriptome profiling by RNA-seq and increased knowledge of the cellular targets of the RNA chaperone Hfq suggest that the bacter...

journal_title：Current opinion in microbiology

authors： Miyakoshi M,Chao Y,Vogel J

更新日期：2015-04-01 00:00:00

abstract：:Recently developed techniques allow genomic DNA sequencing from single microbial cells [Lasken RS: Single-cell genomic sequencing using multiple displacement amplification. Curr Opin Microbiol 2007, 10:510-516]. Here, we focus on research strategies for putting these methods into practice in the laboratory setting. An...

journal_title：Current opinion in microbiology

authors： Ishoey T,Woyke T,Stepanauskas R,Novotny M,Lasken RS

更新日期：2008-06-01 00:00:00

abstract：:The obligatory intracellular bacterial pathogens Anaplasma and Ehrlichia infect leukocytes by hijacking host-cell components and processes. The type IV secretion system is up-regulated during infection. Among type IV secretion candidate substrates, an ankyrin repeat protein of Anaplasma phagocytophilum, AnkA, is deliv...

journal_title：Current opinion in microbiology

authors： Rikihisa Y,Lin M

更新日期：2010-02-01 00:00:00

abstract：:The protozoan parasite Trypanosoma brucei is the causative agent of African sleeping sickness and the wasting disease, nagana, in cattle. The parasite is transmitted to the mammalian host by the bite of a tsetse fly. These parasites lack transcriptional regulation, and their gene expression is mainly regulated post-tr...

journal_title：Current opinion in microbiology

authors： Michaeli S

更新日期：2014-08-01 00:00:00

abstract：:Antisense technology has been widely used to regulate gene expression. A tetracycline (tet)-regulated antisense-RNA-expressing system has been developed and used to downregulate chromosomally derived genes expressed in Staphylococcus aureus. This downregulation subsequently provides an evaluation of the virulence fact...

journal_title：Current opinion in microbiology

authors： Yin D,Ji Y

更新日期：2002-06-01 00:00:00

abstract：:Some RNA virus genomes bear 5'-triphosphates, which can be recognized in the cytoplasm of infected cells by host proteins that mediate anti-viral immunity. Both the innate sensor RIG-I and the interferon-induced IFIT proteins bind to 5'-triphosphate viral RNAs. RIG-I signals for induction of interferons during RNA vir...

journal_title：Current opinion in microbiology

authors： Rehwinkel J,Reis e Sousa C

更新日期：2013-08-01 00:00:00

abstract：:Macrophages protect their host by engulfing foreign bodies within phagosomes that rapidly develop into microbicidal organelles. Numerous pathogens, such as species of Toxoplasma, Leishmania, Mycobacterium, Salmonella and Legionella, thrive in human macrophages, sometimes with disastrous effects. Defining the survival ...

journal_title：Current opinion in microbiology

authors： Amer AO,Swanson MS

更新日期：2002-02-01 00:00:00

abstract：:Sequestered from the action of complement, antibody and lytic peptides, phagosomal pathogens pose a unique problem for the innate immune system both in terms of detection and disposal. An immunologically induced 47-kDa (p47) GTPase family recruited to nascent phagosomes (PGs) has provided new insights into how vertebr...

journal_title：Current opinion in microbiology

authors： MacMicking JD

更新日期：2005-02-01 00:00:00

abstract：:Selective autophagy is an important effector mechanism of cell autonomous immunity, in particular against invasive bacterial species. Anti-bacterial autophagy is activated by rupture of bacteria-containing vacuoles and exposure of bacteria to the cytosol. The autophagy cargo receptors p62, NDP52 and Optineurin detect ...

journal_title：Current opinion in microbiology

authors： Boyle KB,Randow F

更新日期：2013-06-01 00:00:00

abstract：:Despite the widespread availability of genome sequences and the systematic assignment of individual open reading frames, many of the activities of metabolic enzymes are still veiled. It is difficult to assign biochemical functions to enzymes and uncover the in vivo regulation of their enzymatic activities, but this is...

journal_title：Current opinion in microbiology

authors： Saito N,Ohashi Y,Soga T,Tomita M

更新日期：2010-06-01 00:00:00

abstract：:The Saccharomyces cerevisiae genome sequence, augmented by new data on gene expression and function, continues to yield new findings about eukaryote genome evolution. Analysis of the duplicate gene pairs formed by whole-genome duplication indicates that selection for increased levels of gene expression was a significa...

journal_title：Current opinion in microbiology

authors： Seoighe C,Wolfe KH

更新日期：1999-10-01 00:00:00

abstract：:Staphylococcus aureus is a leading cause of hospital-acquired and often persistent infections. A key feature of pathogenic S. aureus is the expression of an array of extracellular matrix-binding proteins. In particular, the fibronectin-binding proteins FnBP-A and FnBP-B afford the pathogen the ability to connect to ce...

journal_title：Current opinion in microbiology

authors： Hauck CR,Ohlsen K

更新日期：2006-02-01 00:00:00

abstract：:Infections caused by Streptococcus pneumoniae are a major cause of morbidity and mortality in the pediatric population worldwide. Development of increasing resistance to multiple classes of antibiotics is making treatment of infections caused by this organism much more difficult. In order to prevent disease, a 23-vale...

journal_title：Current opinion in microbiology

authors： Tan TQ

更新日期：2000-10-01 00:00:00