Non-coding RNA and the complex regulation of the trypanosome life cycle.

abstract：:Intracellular protozoans co-evolved with their mammalian host cells a range of strategies to cope with the composite and dynamic cell surface features they encounter during migration and infection. Therefore, these single-celled eukaryotic parasites represent a fascinating source of living probes for precisely capturi...

journal_title：Current opinion in microbiology

authors： Pavlou G,Milon G,Tardieux I

更新日期：2019-12-01 00:00:00

abstract：:Since their discovery, our understanding of NK cells has evolved from branding them marginal innate immunity cells to key players in anti-viral and anti-tumor immunity. Importance of NK cells in control of various viral infections is perhaps best illustrated by the existence of plethora of viral mechanisms aimed to mo...

journal_title：Current opinion in microbiology

authors： Lisnić VJ,Krmpotić A,Jonjić S

更新日期：2010-08-01 00:00:00

abstract：:DNA translocases play important roles during the bacterial cell cycle and in cell differentiation. Escherichia coli cells contain a multifunctional translocase, FtsK, which is involved in cell division, late steps of chromosome segregation and dimer resolution. In Gram-positive bacteria, the latter two processes are a...

journal_title：Current opinion in microbiology

authors： Kaimer C,Graumann PL

更新日期：2011-12-01 00:00:00

abstract：:The ability to control uptake across the mucosa and to protect the gut from harmful substances present in the lumen is defined as intestinal barrier function. Two routes are usually distinguished for transepithelial transport. The paracellular route allows the passage of ions and small molecules and is mainly regulate...

journal_title：Current opinion in microbiology

authors： Barreau F,Hugot JP

更新日期：2014-02-01 00:00:00

abstract：:Bacterium-host interactions are important for diverse ecological settings including pathogenicity and symbiosis. Electron cryotomography is a powerful method for studying the macromolecular complexes that mediate such interactions in situ. The main limitation of electron cryotomography is its restriction to relatively...

journal_title：Current opinion in microbiology

authors： Medeiros JM,Böck D,Pilhofer M

更新日期：2018-06-01 00:00:00

abstract：:Recent work on cell division and chromosome orientation and partitioning in Bacillus subtilis has provided insights into cell cycle regulation during growth and development. The cell cycle is an integral part of development and entrance into sporulation is modulated by signals that transmit the status of DNA integrity...

journal_title：Current opinion in microbiology

authors： Levin PA,Grossman AD

更新日期：1998-12-01 00:00:00

abstract：:Inflammasomes - molecular platforms for caspase-1 activation - have emerged as common hubs for a number of pathways that detect and respond to bacterial pathogens. Caspase-1 activation results in the secretion of bioactive IL-1β and IL-18 and pyroptosis, and thus launches a systemic immune and inflammatory response. I...

journal_title：Current opinion in microbiology

authors： Eldridge MJ,Shenoy AR

更新日期：2015-02-01 00:00:00

abstract：:Analyses of the complex regulatory networks leading to T cell survival, death, and immune deficiency have been aided in the past year by the dramatic development of new technologies to identify T cells and assess T cell function. These new techniques have shown that functional inactivation and apoptotic elimination of...

journal_title：Current opinion in microbiology

authors： Welsh RM,McNally JM

更新日期：1999-08-01 00:00:00

abstract：:Viruses attach to specific receptors, but identified receptors are often absent from the epithelial surfaces where infections begin. Viruses can bind to alternative receptor molecules present on epithelial surfaces and they can enter hosts in ways that bypass mucosal barriers to infection. To understand how viruses cr...

journal_title：Current opinion in microbiology

authors： Bergelson JM

更新日期：2003-08-01 00:00:00

abstract：:According to a Pew Research study published in February 2015, there are 37 antibacterial programs currently in clinical trials in the United States. Protein structure-based methods for guiding small molecule design were used in at least 34 of these programs. Typically, this occurred at an early stage (drug discovery a...

journal_title：Current opinion in microbiology

authors： Staker BL,Buchko GW,Myler PJ

更新日期：2015-10-01 00:00:00

abstract：:Upon infection, both DNA and RNA viruses can be sensed by pattern recognition receptors (PRRs) in the cytoplasm or the nucleus to activate antiviral innate immunity. Sensing of viral products leads to the activation of a signaling cascade that ultimately results in transcriptional activation of type I and III interfer...

journal_title：Current opinion in microbiology

authors： Beachboard DC,Horner SM

更新日期：2016-08-01 00:00:00

abstract：:Kinetoplastea such as trypanosomatid parasites contain specialized peroxisomes that uniquely contain enzymes of the glycolytic pathway and other parts of intermediary metabolism and hence are called glycosomes. Their specific enzyme content can vary strongly, quantitatively and qualitatively, between different species...

journal_title：Current opinion in microbiology

authors： Szöör B,Haanstra JR,Gualdrón-López M,Michels PA

更新日期：2014-12-01 00:00:00

abstract：:There has been a dramatic increase in the number of completely sequenced bacterial genomes during the past two years as a result of the efforts both of public genome agencies and the pharmaceutical industry. The availability of completely sequenced genomes permits more systematic analyses of genes, evolution and genom...

journal_title：Current opinion in microbiology

authors： Brutlag DL

更新日期：1998-06-01 00:00:00

abstract：:Chemical communication between cells ensures coordination of behavior. In prokaryotes, this chemical communication is usually referred to as quorum sensing, while eukaryotic cells signal through hormones. In the past years, a growing number of reports have shown that bacterial quorum sensing signals, called autoinduce...

journal_title：Current opinion in microbiology

authors： Pacheco AR,Sperandio V

更新日期：2009-04-01 00:00:00

abstract：:The historical paradigm of the deep ocean as a biological 'desert' has shifted to one of a 'rainforest' owing to the isolation of many novel microbes and their associated bioactive compounds. Recently, there has been an explosion of information about novel bioactive compounds that have been isolated from marine microb...

journal_title：Current opinion in microbiology

authors： Zhang L,An R,Wang J,Sun N,Zhang S,Hu J,Kuai J

更新日期：2005-06-01 00:00:00

abstract：:Xenogeneic silencing proteins facilitate horizontal gene transfer by silencing expression of AT-rich sequences. By virtue of their activity these proteins serve as master regulators of a variety of important functions including motility, drug resistance, and virulence. Three families of silencers have been identified ...

journal_title：Current opinion in microbiology

authors： Ali SS,Xia B,Liu J,Navarre WW

更新日期：2012-04-01 00:00:00

abstract：:Pneumococcal conjugate vaccine is not only effective against invasive and non-invasive disease in all ages but also has a significant impact on antibiotic-resistant infections since a number of resistant serotypes are targeted by the vaccine. Surveillance studies in the post-licensure years have shown an increase in n...

journal_title：Current opinion in microbiology

authors： McGee L

更新日期：2007-10-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) is highly immunogenic and appears to have evolved to preserve its antigenicity. The retention of antigenicity is important to the maintenance of a robust immune response that contributes greatly to the late-stage tissue damage required for transmission and completion of the pathogen's ...

journal_title：Current opinion in microbiology

authors： Russell DG

更新日期：2013-02-01 00:00:00

abstract：:Endosymbiotic theory goes back over 100 years. It explains the similarity of chloroplasts and mitochondria to free-living prokaryotes by suggesting that the organelles arose from prokaryotes through (endo)symbiosis. Gene trees provide important evidence in favour of symbiotic theory at a coarse-grained level, but the ...

journal_title：Current opinion in microbiology

authors： Zimorski V,Ku C,Martin WF,Gould SB

更新日期：2014-12-01 00:00:00

abstract：:Intracellular bacteria in mammalian host cells can either live in a membrane-bound vacuole modified to support bacterial growth, or escape from the primary phagosome into the host cell cytoplasm. Phagosomal escape is best studied in Listeria monocytogenes in which a pore-forming cytolysin and two phospholipases are in...

journal_title：Current opinion in microbiology

authors： Goebel W,Kuhn M

更新日期：2000-02-01 00:00:00

abstract：:Infections caused by Streptococcus pneumoniae are a major cause of morbidity and mortality in the pediatric population worldwide. Development of increasing resistance to multiple classes of antibiotics is making treatment of infections caused by this organism much more difficult. In order to prevent disease, a 23-vale...

journal_title：Current opinion in microbiology

authors： Tan TQ

更新日期：2000-10-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a clinically significant herpes virus that maintains a lifelong infection in the host. HCMV infection of endothelial cells and macrophages plays an important role in the establishment of latency and persistence, which appears critical for the maintenance of HCMV within the host. HCMV in...

journal_title：Current opinion in microbiology

authors： Jarvis MA,Nelson JA

更新日期：2002-08-01 00:00:00

abstract：:In Gram-negative bacteria such as Escherichia coli the peptidoglycan sacculus resides in the periplasm, a compartment that experiences changes in pH value, osmolality, ion strength and other parameters depending on the cell's environment. Hence, the cell needs robust peptidoglycan growth mechanisms to grow and divide ...

journal_title：Current opinion in microbiology

authors： Pazos M,Peters K,Vollmer W

更新日期：2017-04-01 00:00:00

abstract：:Cyanobacteria possess the simplest known circadian clock, which presents a unique opportunity to study how rhythms are generated and how input signals from the environment reset the clock time. The kaiABC locus forms the core of the oscillator, and the remarkable ability to reconstitute oscillations using purified Kai...

journal_title：Current opinion in microbiology

authors： Pattanayak G,Rust MJ

更新日期：2014-04-01 00:00:00

abstract：:Sexual development in filamentous ascomycetes requires mating-type genes to mediate recognition of compatible cell and nuclear types. Characterization of mating-type genes from various fungi shows that they primarily encode transcriptional regulators. Recent studies on mating-type-specific pheromones and internuclear ...

journal_title：Current opinion in microbiology

authors： Shiu PK,Glass NL

更新日期：2000-04-01 00:00:00

abstract：:Activation of professional phagocytes with the concomitant generation of oxidant species is a medullar innate immune process for the control of acute Trypanosoma cruzi infection. Recent data reinforce the hypothesis that parasites more prepared to deal with the host-oxidative assault are more efficient for the establi...

journal_title：Current opinion in microbiology

authors： Piacenza L,Alvarez MN,Peluffo G,Radi R

更新日期：2009-08-01 00:00:00

abstract：:In this review, we demonstrate how game theory can be a useful first step in modeling and understanding interactions among bacteria that produce and resist antibiotics. We introduce the basic features of evolutionary game theory and explore model microbial systems that correspond to some classical games. Each game dis...

journal_title：Current opinion in microbiology

authors： Conlin PL,Chandler JR,Kerr B

更新日期：2014-10-01 00:00:00

abstract：:In this paper, we discuss recent advances in our knowledge of the dengue virus life cycle based on new structural data of the virus and its proteins. Specifically, we focus on the structure of the pre-membrane protein, prM and its role in virus assembly, the first full-length structure of a multi-domain dengue virus r...

journal_title：Current opinion in microbiology

authors： Perera R,Kuhn RJ

更新日期：2008-08-01 00:00:00

abstract：:A specialized cortical domain is organized by the septins at the necks of budding yeast cells. Recent findings suggest that this domain serves as a diffusion barrier and also as a local cell-shape sensor. We review these findings along with what is known about the organization of the septin cortex and its regulation d...

journal_title：Current opinion in microbiology

authors： Gladfelter AS,Pringle JR,Lew DJ

更新日期：2001-12-01 00:00:00

abstract：:Two-thirds of all bacterial genomes sequenced to-date possess an organelle for locomotion, referred to as flagella, periplasmic flagella or type IV pili. These genomes may also contain a chemotaxis-signaling system which governs flagellar rotation, thus leading a coordinated function for motility. Motility and chemota...

journal_title：Current opinion in microbiology

authors： Motaleb MA,Liu J,Wooten RM

更新日期：2015-12-01 00:00:00