Abstract:
:In Gram-negative bacteria such as Escherichia coli the peptidoglycan sacculus resides in the periplasm, a compartment that experiences changes in pH value, osmolality, ion strength and other parameters depending on the cell's environment. Hence, the cell needs robust peptidoglycan growth mechanisms to grow and divide under different conditions. Here we propose a model according to which the cell achieves robust peptidoglycan growth by employing dynamic multi-protein complexes, which assemble with variable composition from freely diffusing sets of peptidoglycan synthases, hydrolases and their regulators, whereby the composition of the active complexes depends on the cell cycle state - cell elongation or division - and the periplasmic growth conditions.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Pazos M,Peters K,Vollmer Wdoi
10.1016/j.mib.2017.01.006subject
Has Abstractpub_date
2017-04-01 00:00:00pages
55-61eissn
1369-5274issn
1879-0364pii
S1369-5274(16)30146-1journal_volume
36pub_type
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