Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions.

Abstract:

:Trypanosomes and Leishmania contain an abundance of stage-regulated cysteine proteinases encoded by several gene families. Analysis of parasites rendered defective in cysteine proteinase function, either through genetic manipulation or through the use of specific inhibitors, has revealed roles for the enzymes in parasite virulence, in modulation of the host's immune response and in parasite differentiation.

journal_name

Curr Opin Microbiol

authors

Mottram JC,Brooks DR,Coombs GH

doi

10.1016/s1369-5274(98)80065-9

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

455-60

issue

4

eissn

1369-5274

issn

1879-0364

pii

S1369-5274(98)80065-9

journal_volume

1

pub_type

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