Bacterial morphogenesis: learning how cells make cells.


:Bacteria furnish tractable models for complex biological processes, and morphogenesis is now taking its turn. We can already explain in general terms how such elementary forms as rods and cocci are produced, and the shapes of several individual organisms are coming into focus. In most bacteria shape is maintained by the cell wall, specifically the peptidoglycan layer, which has the attributes of a strong stiff fabric. Compliance of that fabric with turgor pressure is an important aspect of morphogenesis. The shape of the wall sacculus is determined by the way it is deposited, which is controlled by a cytoskeleton made up of two molecular families. One, related to the eukaryotic tubulins, is responsible for the construction of the septum and the poles. The other, related to eukaryotic actins, localizes peptidoglycan synthesis in the lateral walls of rod-shaped cells. Just how the cytoskeleton itself is organized remains to be discovered, but it seems likely that, as in eukaryotes, the cytoskeleton is produced by self-organized assembly, guided by the fabric of the cell.


Curr Opin Microbiol


Harold FM




Has Abstract


2007-12-01 00:00:00














  • Cell and nuclear recognition mechanisms mediated by mating type in filamentous ascomycetes.

    abstract::Sexual development in filamentous ascomycetes requires mating-type genes to mediate recognition of compatible cell and nuclear types. Characterization of mating-type genes from various fungi shows that they primarily encode transcriptional regulators. Recent studies on mating-type-specific pheromones and internuclear ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Shiu PK,Glass NL

    更新日期:2000-04-01 00:00:00

  • Global relative and absolute quantitation in microbial proteomics.

    abstract::Proteomic studies are designed to yield either qualitative information on proteins (identification, distribution, posttranslational modifications, interactions, structure and function) or quantitative information (abundance, distribution within different localizations, temporal changes in abundance due to synthesis an...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Otto A,Bernhardt J,Hecker M,Becher D

    更新日期:2012-06-01 00:00:00

  • Persistence: a copacetic and parsimonious hypothesis for the existence of non-inherited resistance to antibiotics.

    abstract::We postulate that phenotypic resistance to antibiotics, persistence, is not an evolved (selected-for) character but rather like mutation, an inadvertent product of different kinds of errors and glitches. The rate of generation of these errors is augmented by exposure to these drugs. The genes that have been identified...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Levin BR,Concepción-Acevedo J,Udekwu KI

    更新日期:2014-10-01 00:00:00

  • Unveiling cellular biochemical reactions via metabolomics-driven approaches.

    abstract::Despite the widespread availability of genome sequences and the systematic assignment of individual open reading frames, many of the activities of metabolic enzymes are still veiled. It is difficult to assign biochemical functions to enzymes and uncover the in vivo regulation of their enzymatic activities, but this is...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Saito N,Ohashi Y,Soga T,Tomita M

    更新日期:2010-06-01 00:00:00

  • Animal models in the analysis of Candida host-pathogen interactions.

    abstract::An increasingly diverse array of clinically relevant animal models of candidiasis have been established that mimic both the immune perturbations of the host and tissue-specific features of candidiasis in humans. Cause-and-effect analysis of Candida host-pathogen interactions using these animal models has made a quantu...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: de Repentigny L

    更新日期:2004-08-01 00:00:00

  • Inhibition of CRISPR-Cas systems by mobile genetic elements.

    abstract::Clustered, regularly interspaced, short, palindromic repeats (CRISPR) loci, together with their CRISPR-associated (Cas) proteins, provide bacteria and archaea with adaptive immunity against invasion by bacteriophages, plasmids, and other mobile genetic elements. These host defenses impart selective pressure on phages ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Sontheimer EJ,Davidson AR

    更新日期:2017-06-01 00:00:00

  • Single-cell genomic sequencing using Multiple Displacement Amplification.

    abstract::Single microbial cells can now be sequenced using DNA amplified by the Multiple Displacement Amplification (MDA) reaction. The few femtograms of DNA in a bacterium are amplified into micrograms of high molecular weight DNA suitable for DNA library construction and Sanger sequencing. The MDA-generated DNA also performs...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Lasken RS

    更新日期:2007-10-01 00:00:00

  • Transitions and transmission: behavior and physiology as drivers of honey bee-associated microbial communities.

    abstract::Microbial communities have considerable impacts on animal health. However, only in recent years have the host factors impacting microbiome composition been explored. An increasing wealth of microbiome data in combination with decades of research on behavior, physiology, and development have resulted in the European ho...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Miller DL,Parish AJ,Newton IL

    更新日期:2019-08-01 00:00:00

  • Next-generation precision antimicrobials: towards personalized treatment of infectious diseases.

    abstract::Antibiotics started to be used almost 90 years ago to eradicate life-threatening infections. The urgency of the problem required rapid, broad-spectrum elimination of infectious agents. Since their initial discovery, these antimicrobials have saved millions of lives. However, they are not exempt from side effects, whic...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: de la Fuente-Nunez C,Torres MD,Mojica FJ,Lu TK

    更新日期:2017-06-01 00:00:00

  • Rewiring two-component signal transduction with small RNAs.

    abstract::Bacterial two-component systems (TCSs) and small regulatory RNAs (sRNAs) form densely interconnected networks that integrate and transduce information from the environment into fine-tuned changes of gene expression. Many TCSs control target genes indirectly through regulation of sRNAs, which in turn regulate gene expr...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Göpel Y,Görke B

    更新日期:2012-04-01 00:00:00

  • The tritrophic trinity: a source of pollutant-degrading enzymes and its implications for phytoremediation.

    abstract::Barring bioavailability and nutritional limitations, virtually all organic anthropogenic chemicals can be naturally biodegraded. It is to this phenomenon we owe thanks to the long established 'tritrophic trinity' of microbe-plant-insect interactions. Over hundreds of millennia these organisms have coevolved, producing...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Singer AC,Thompson IP,Bailey MJ

    更新日期:2004-06-01 00:00:00

  • Collaborative signaling by bacterial chemoreceptors.

    abstract::Motile bacteria seek optimal living habitats by following gradients of attractant and repellent chemicals in their environment. The signaling machinery for these chemotactic behaviors, although assembled from just a few protein components, has extraordinary information-processing capabilities. Escherichia coli, the be...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Parkinson JS,Ames P,Studdert CA

    更新日期:2005-04-01 00:00:00

  • Imaging bacteria inside their host by cryo-focused ion beam milling and electron cryotomography.

    abstract::Bacterium-host interactions are important for diverse ecological settings including pathogenicity and symbiosis. Electron cryotomography is a powerful method for studying the macromolecular complexes that mediate such interactions in situ. The main limitation of electron cryotomography is its restriction to relatively...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Medeiros JM,Böck D,Pilhofer M

    更新日期:2018-06-01 00:00:00

  • Probing the mechanistic principles of bacterial cell division with super-resolution microscopy.

    abstract::Bacterial cell division takes place almost entirely below the diffraction limit of light microscopy, making super-resolution microscopy ideally suited to interrogating this process. I review how super-resolution microscopy has advanced our understanding of bacterial cell division. I discuss the mechanistic implication...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Holden S

    更新日期:2018-06-01 00:00:00

  • The crucial role of iron uptake in Aspergillus fumigatus virulence.

    abstract::Aspergillus fumigatus is an opportunistic fungal pathogen that causes life-threatening infections in immunocompromised individuals. Siderophore-mediated iron acquisition has been shown to be essential for virulence. New studies have revealed that enzymes involved in siderophore biosynthesis and uptake are compartmenta...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Moore MM

    更新日期:2013-12-01 00:00:00

  • Molecular basis of pathogenicity in Blastomyces dermatitidis: the importance of adhesion.

    abstract::An understanding of the molecular bases of pathogenicity in Blastomyces dermatitidis and related systemic dimorphic fungi has been limited until recent years. Yeast cells of B. dermatitidis display an adhesion promoting protein termed WI-1. Recent studies entailing homologous gene targeting and mutation of WI-1 have p...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Klein BS

    更新日期:2000-08-01 00:00:00

  • Control of transcription by nucleoid proteins.

    abstract::Nucleoid proteins are a group of abundant DNA binding proteins that modulate the structure of the bacterial chromosome. They have been recruited as specific negative and positive regulators of gene transcription and their fluctuating patterns of expression are often exploited to impart an additional level of control w...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章


    authors: McLeod SM,Johnson RC

    更新日期:2001-04-01 00:00:00

  • Using laser tweezers to measure twitching motility in Neisseria.

    abstract::Dynamic properties of type IV pili are essential for their function in bacterial infection, twitching motility and gene transfer. Laser tweezers are versatile tools to study the molecular mechanism underlying pilus dynamics at the single molecule level. Recently, these optical tweezers have been used to monitor pilus ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Maier B

    更新日期:2005-06-01 00:00:00

  • Mycobacterium tuberculosis in the post-genomic age.

    abstract::Since the publication of the complete genome sequence of Mycobacterium tuberculosis in 1998, there has been a marked intensification and diversification of activities in the field of tuberculosis research. Among the areas that have advanced spectacularly are comparative genomics, functional genomics-notably the study ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Domenech P,Barry CE 3rd,Cole ST

    更新日期:2001-02-01 00:00:00

  • The mycobiota: fungi take their place between plants and bacteria.

    abstract::Eukaryotes host numerous intracellular and associated microbes in their microbiota. Fungi, the so-called Mycobiota, are important members of both human and plant microbiota. Moreover, members of the plant mycobiota host their own microbiota on their surfaces and inside their hyphae. The microbiota of the mycobiota inc...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Bonfante P,Venice F,Lanfranco L

    更新日期:2019-06-01 00:00:00

  • Cytoskeleton and motor proteins in filamentous fungi.

    abstract::In filamentous fungi, the actin cytoskeleton is required for polarity establishment and maintenance at hyphal tips and for formation of a contractile ring at sites of septation. Recently, formins have been identified as Arp (actin-related protein) 2/3-independent nucleators of actin polymerization, and filamentous fun...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Xiang X,Plamann M

    更新日期:2003-12-01 00:00:00

  • Cell cycle and sporulation in Bacillus subtilis.

    abstract::Recent work on cell division and chromosome orientation and partitioning in Bacillus subtilis has provided insights into cell cycle regulation during growth and development. The cell cycle is an integral part of development and entrance into sporulation is modulated by signals that transmit the status of DNA integrity...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Levin PA,Grossman AD

    更新日期:1998-12-01 00:00:00

  • Phylogeny of the genus Arenavirus.

    abstract::The family Arenaviridae consists of a unique genus (Arenavirus) that currently comprises 22 viral species, as recognized by the International Committee for Taxonomy of Viruses. Seven newly discovered represent putative new species. Here, our aims were to provide the most comprehensive phylogenetic analysis of members ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Charrel RN,de Lamballerie X,Emonet S

    更新日期:2008-08-01 00:00:00

  • Intestinal organoid/enteroid-based models for Cryptosporidium.

    abstract::Cryptosporidium is a leading cause of diarrhea and death in young children and untreated AIDS patients in resource-poor settings, and of waterborne outbreaks of disease in developed countries. However, there is no consistently effective treatment for vulnerable populations. Progress towards development of therapeutics...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Bhalchandra S,Lamisere H,Ward H

    更新日期:2020-12-01 00:00:00

  • Prospects for new antitubercular drugs.

    abstract::The inexorable rise in cases of tuberculosis worldwide, fuelled by the HIV epidemic, highlights the need for new drugs and particularly those that can shorten the duration of treatment. Clinical trials of existing broad-spectrum agents such as the fluoroquinolone moxifloxacin are proceeding, on the basis of efficacy i...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Duncan K,Barry CE 3rd

    更新日期:2004-10-01 00:00:00

  • Mining genome databases to identify and understand new gene regulatory systems.

    abstract::The availability of a large number of sequenced microbial genomes allows us to conduct systematic studies on microbial gene regulatory systems. Computational methods, using comparative genomics approaches, are powerful tools to understand their mechanisms and evolutionary history. Recent advances in computational meth...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Stormo GD,Tan K

    更新日期:2002-04-01 00:00:00

  • Connections between transcriptional regulation and type III secretion?

    abstract::Type III secretion is a mechanism of protein export in bacteria, by which proteins (termed effectors) are exported from the bacteria to the external environment. One topic that has escaped much attention is the potential link between the secretion of effectors and transcriptional regulation of genes encoding the effec...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Miller VL

    更新日期:2002-04-01 00:00:00

  • Virus interactions with mucosal surfaces: alternative receptors, alternative pathways.

    abstract::Viruses attach to specific receptors, but identified receptors are often absent from the epithelial surfaces where infections begin. Viruses can bind to alternative receptor molecules present on epithelial surfaces and they can enter hosts in ways that bypass mucosal barriers to infection. To understand how viruses cr...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Bergelson JM

    更新日期:2003-08-01 00:00:00

  • Genomics of parasitic and symbiotic fungi.

    abstract::Complete and partial genome sequence information is underway in several parasitic and symbiotic fungi that infect humans, other animals and plants. Comparative analyses of these sequences will provide new insights into the genomic plasticity and evolution of parasitism and mutualism in fungi. ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Tunlid A,Talbot NJ

    更新日期:2002-10-01 00:00:00

  • Antimicrobial inflammasomes: unified signalling against diverse bacterial pathogens.

    abstract::Inflammasomes - molecular platforms for caspase-1 activation - have emerged as common hubs for a number of pathways that detect and respond to bacterial pathogens. Caspase-1 activation results in the secretion of bioactive IL-1β and IL-18 and pyroptosis, and thus launches a systemic immune and inflammatory response. I...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Eldridge MJ,Shenoy AR

    更新日期:2015-02-01 00:00:00