Type VI secretion and anti-host effectors.

abstract：:Just as we thought that we know everything about superantigens, new molecular and structural studies indicate that we have only just begun to unravel the secrets of these fascinating molecules. Recent structure-function analysis of superantigens from Gram-positive bacteria, with emphasis on their interaction with majo...

journal_title：Current opinion in microbiology

authors： Kotb M

更新日期：1998-02-01 00:00:00

abstract：:Clustered, regularly interspaced, short, palindromic repeats (CRISPR) loci, together with their CRISPR-associated (Cas) proteins, provide bacteria and archaea with adaptive immunity against invasion by bacteriophages, plasmids, and other mobile genetic elements. These host defenses impart selective pressure on phages ...

journal_title：Current opinion in microbiology

authors： Sontheimer EJ,Davidson AR

更新日期：2017-06-01 00:00:00

abstract：:Most Candida albicans strains are heterozygous at the MTL (mating-type-like) locus, but mating occurs in hemi- or homozygous strains. The white-opaque switch process is repressed by the heterodimer of the MTLa1 and MTLalpha2 gene products, while mating genes are induced by a2 and alpha1. Mating occurs in opaque cells ...

journal_title：Current opinion in microbiology

authors： Magee PT,Magee BB

更新日期：2004-12-01 00:00:00

abstract：:Legionella pneumophila is a water-borne opportunistic pathogen causing a life-threatening pneumonia called 'Legionnaires' disease'. The Legionella quorum sensing (Lqs) system produces and responds to the α-hydroxyketone signaling molecule 3-hydroxypentadecane-4-one (Legionella autoinducer-1, LAI-1). The Lqs system con...

journal_title：Current opinion in microbiology

authors： Personnic N,Striednig B,Hilbi H

更新日期：2018-02-01 00:00:00

abstract：:Atomic force microscopy imaging and force spectroscopy have recently opened a range of novel applications in microbiology. During the past two years, rapid advances have been made using atomic force microscopy to visualize the surface structure of two-dimensional bacterial protein crystals, biofilms and individual cel...

journal_title：Current opinion in microbiology

authors： Dufrêne YF

更新日期：2003-06-01 00:00:00

abstract：:Staphylococcus aureus is a dangerous pathogen that causes a variety of severe diseases. The virulence of S. aureus is defined by a large repertoire of virulence factors, among which secreted toxins play a preeminent role. Many S. aureus toxins damage biological membranes, leading to cell death. In particular, S. aureu...

journal_title：Current opinion in microbiology

authors： Otto M

更新日期：2014-02-01 00:00:00

abstract：:The yeast Saccharomyces cerevisiae senses and responds to nutrients by adapting its growth rate and undergoing morphogenic transitions to ensure survival. The Tor pathway is a major integrator of nutrient-derived signals that in coordination with other signaling pathways orchestrates cell growth. Recent advances have ...

journal_title：Current opinion in microbiology

authors： Rohde JR,Bastidas R,Puria R,Cardenas ME

更新日期：2008-04-01 00:00:00

abstract：:Quorum sensing, or the control of gene expression in response to cell density, is used by both gram-negative and gram-positive bacteria to regulate a variety of physiological functions. In all cases, quorum sensing involves the production and detection of extracellular signalling molecules called autoinducers. While u...

journal_title：Current opinion in microbiology

authors： Bassler BL

更新日期：1999-12-01 00:00:00

abstract：:In filamentous fungi, the actin cytoskeleton is required for polarity establishment and maintenance at hyphal tips and for formation of a contractile ring at sites of septation. Recently, formins have been identified as Arp (actin-related protein) 2/3-independent nucleators of actin polymerization, and filamentous fun...

journal_title：Current opinion in microbiology

authors： Xiang X,Plamann M

更新日期：2003-12-01 00:00:00

abstract：:While natural microbial communities are composed of a mix of microbes with often unknown functions, the construction of synthetic microbial communities allows for the generation of defined systems with reduced complexity. Used in a top-down approach, synthetic communities serve as model systems to ask questions about ...

journal_title：Current opinion in microbiology

authors： Grosskopf T,Soyer OS

更新日期：2014-04-01 00:00:00

abstract：:In the last 30 years, significant advances in genetic manipulation tools along with complete genome and transcriptome sequencing have advanced our understanding of the biology of Leishmania parasites and their interplay with the sand fly and mammalian hosts. High-throughput sequencing in association with CRISPR/Cas9 h...

journal_title：Current opinion in microbiology

authors： Cruz AK,Freitas-Castro F

更新日期：2019-12-01 00:00:00

abstract：:Aspergillus fumigatus is an opportunistic fungal pathogen that causes life-threatening infections in immunocompromised individuals. Siderophore-mediated iron acquisition has been shown to be essential for virulence. New studies have revealed that enzymes involved in siderophore biosynthesis and uptake are compartmenta...

journal_title：Current opinion in microbiology

authors： Moore MM

更新日期：2013-12-01 00:00:00

abstract：:Two-thirds of all bacterial genomes sequenced to-date possess an organelle for locomotion, referred to as flagella, periplasmic flagella or type IV pili. These genomes may also contain a chemotaxis-signaling system which governs flagellar rotation, thus leading a coordinated function for motility. Motility and chemota...

journal_title：Current opinion in microbiology

authors： Motaleb MA,Liu J,Wooten RM

更新日期：2015-12-01 00:00:00

abstract：:Pneumococcal conjugate vaccine is not only effective against invasive and non-invasive disease in all ages but also has a significant impact on antibiotic-resistant infections since a number of resistant serotypes are targeted by the vaccine. Surveillance studies in the post-licensure years have shown an increase in n...

journal_title：Current opinion in microbiology

authors： McGee L

更新日期：2007-10-01 00:00:00

abstract：:Molecular phylogenetic studies reveal that many endosymbioses between bacteria and invertebrate hosts result from ancient infections followed by strict vertical transmission within host lineages. Endosymbionts display a distinctive constellation of genetic properties including AT-biased base composition, accelerated s...

journal_title：Current opinion in microbiology

authors： Moran NA,Baumann P

更新日期：2000-06-01 00:00:00

abstract：:The 21st century has seen the licensure of new anti-infective vaccines that have demonstrated their benefit for both individual and population (herd) protection. Despite this there are still many human pathogens for which no vaccine is available. As we learn more about these pathogens, and as technologies advance, mor...

journal_title：Current opinion in microbiology

authors： Scully IL,Swanson K,Green L,Jansen KU,Anderson AS

更新日期：2015-10-01 00:00:00

abstract：:Recently, a number of endophytic fungi have been discovered that produce volatile organic compounds (VOCs) whilst growing on agricultural waste substrates, whose chemistry is best defined as hydrocarbon and hydrocarbon-like. These compounds have potential use as both 'green chemicals' and fuels. This report discusses ...

journal_title：Current opinion in microbiology

authors： Strobel G

更新日期：2014-06-01 00:00:00

abstract：:Most studies of small regulatory RNAs in bacteria have focussed on conserved transcripts in intergenic regions. However, several recent developments including single-nucleotide resolution transcriptome profiling by RNA-seq and increased knowledge of the cellular targets of the RNA chaperone Hfq suggest that the bacter...

journal_title：Current opinion in microbiology

authors： Miyakoshi M,Chao Y,Vogel J

更新日期：2015-04-01 00:00:00

abstract：:Wild Escherichia coli are superbly adapted to survive in the intestines of their mammalian hosts and in the environment. E. coli K12 derivative (MG1655) encodes 4288 potential genes that provide the background genetic framework of this species. Particular E. coli clonal types encode additional chromosomal and extrachr...

journal_title：Current opinion in microbiology

authors： Dougan G,Haque A,Pickard D,Frankel G,O'Goara P,Wain J

更新日期：2001-02-01 00:00:00

abstract：:Staphylococcus aureus is a leading cause of hospital-acquired and often persistent infections. A key feature of pathogenic S. aureus is the expression of an array of extracellular matrix-binding proteins. In particular, the fibronectin-binding proteins FnBP-A and FnBP-B afford the pathogen the ability to connect to ce...

journal_title：Current opinion in microbiology

authors： Hauck CR,Ohlsen K

更新日期：2006-02-01 00:00:00

abstract：:The discovery of tubulin-like cytoskeletal proteins carried on the genomes of bacteriophages that are actively used for phage propagation during both the lytic and lysogenic cycle have revealed that there at least two ways that viruses can utilize a cytoskeleton; co-opt the host cytoskeleton or bring their own homolog...

journal_title：Current opinion in microbiology

authors： Erb ML,Pogliano J

更新日期：2013-12-01 00:00:00

abstract：:N(6)-methyl-adenines can serve as epigenetic signals for interactions between regulatory DNA sequences and regulatory proteins that control cellular functions, such as the initiation of chromosome replication or the expression of specific genes. Several of these genes encode master regulators of the bacterial cell cyc...

journal_title：Current opinion in microbiology

authors： Collier J

更新日期：2009-12-01 00:00:00

abstract：:Phagocytic cells, including macrophages, neutrophils and dendritic cells, are critical components of the innate immune response to bacterial pathogens such as Salmonella typhimurium. These cells can have several roles during the early stage of an infection including controlling bacterial replication and producing cyto...

journal_title：Current opinion in microbiology

authors： Wick MJ

更新日期：2004-02-01 00:00:00

abstract：:The RNA chaperone protein Hfq is critical to the function of small, base pairing RNAs in many bacteria. In the past few years, structures and modeling of wild type Hfq and assays of various mutants have documented that the homohexameric Hfq ring can contact RNA at four sites (proximal face, distal face, rim and C-term...

journal_title：Current opinion in microbiology

authors： Updegrove TB,Zhang A,Storz G

更新日期：2016-04-01 00:00:00

abstract：:Mycobacterium tuberculosis, the causative agent of human tuberculosis is one of the most widely spread human pathogens. It has succeeded to infect a quarter of the global human population by developing most sophisticated ways to circumvent innate and adaptive immune defences. This highly specialized, major human patho...

journal_title：Current opinion in microbiology

authors： Orgeur M,Brosch R

更新日期：2018-02-01 00:00:00

abstract：:Type III secretion is a mechanism of protein export in bacteria, by which proteins (termed effectors) are exported from the bacteria to the external environment. One topic that has escaped much attention is the potential link between the secretion of effectors and transcriptional regulation of genes encoding the effec...

journal_title：Current opinion in microbiology

authors： Miller VL

更新日期：2002-04-01 00:00:00

abstract：:Membrane shape is functionally linked with many cellular processes. The limiting membrane of vacuoles containing Toxoplasma gondii and Plasmodium apicomplexan parasites lies at the host-parasite interface. This membrane comprises intra-vacuolar and extra-vacuolar tubulo-vesicular deformations, which influence host-par...

journal_title：Current opinion in microbiology

authors： Santi-Rocca J,Blanchard N

更新日期：2017-12-01 00:00:00

abstract：:In two-component signaling systems, phosphorylated response regulators (RRs) are often dephosphorylated by their partner kinases in order to control the in vivo concentration of phospho-RR (RR approximately P). This activity is easily demonstrated in vitro, but these experiments have typically used very high concentra...

journal_title：Current opinion in microbiology

authors： Kenney LJ

更新日期：2010-04-01 00:00:00

abstract：:The availability of genome information for microbial consortia, including unculturable species, from environmental samples has enabled systems-biology interrogation by providing a means to access genomic, transcriptomic, and proteomic information. This provides a unique opportunity to characterize the molecular activi...

journal_title：Current opinion in microbiology

authors： Hettich RL,Sharma R,Chourey K,Giannone RJ

更新日期：2012-06-01 00:00:00

abstract：:Marine viruses often contain host-derived metabolic genes (i.e., auxiliary metabolic genes; AMGs), which are hypothesized to increase viral replication by augmenting key steps in host metabolism. Currently described AMGs encompass a wide variety of metabolic functions, including amino acid and carbohydrate metabolism,...

journal_title：Current opinion in microbiology

authors： Hurwitz BL,U'Ren JM

更新日期：2016-06-01 00:00:00