Bacterial endosymbionts in animals.

abstract：:Extracytoplasmic function σ factors (ECFs) represent a fundamental and widely distributed principle of bacterial signal transduction that connects the perception of a stimulus (input) with the induction of an appropriate set of genes (output). In recent years, comparative genomics analyses have not only allowed a syst...

journal_title：Current opinion in microbiology

authors： Mascher T

更新日期：2013-04-01 00:00:00

abstract：:It is well accepted that bacterial pathogens growing in a biofilm are recalcitrant to the action of most antibiotics and are resistant to the innate immune system. New treatment modalities are greatly warranted to effectively eradicate these infections. However, bacteria growing in a biofilm are metabolically unique i...

journal_title：Current opinion in microbiology

authors： Fey PD

更新日期：2010-10-01 00:00:00

abstract：:Atomic force microscopy imaging and force spectroscopy have recently opened a range of novel applications in microbiology. During the past two years, rapid advances have been made using atomic force microscopy to visualize the surface structure of two-dimensional bacterial protein crystals, biofilms and individual cel...

journal_title：Current opinion in microbiology

authors： Dufrêne YF

更新日期：2003-06-01 00:00:00

abstract：:Bacteria furnish tractable models for complex biological processes, and morphogenesis is now taking its turn. We can already explain in general terms how such elementary forms as rods and cocci are produced, and the shapes of several individual organisms are coming into focus. In most bacteria shape is maintained by t...

journal_title：Current opinion in microbiology

authors： Harold FM

更新日期：2007-12-01 00:00:00

abstract：:The DNA-binding domains of eucaryotic GATA factors comprise a four-cysteine Zn finger and an adjacent basic region. Fungal GATA factors regulate nitrogen metabolism, light induction, siderophore biosynthesis and mating-type switching. Hydrophobic interactions determine binding-site specificity. Interactions with other...

journal_title：Current opinion in microbiology

authors： Scazzocchio C

更新日期：2000-04-01 00:00:00

abstract：:Molecular techniques are providing unprecedented insights into the organismal and functional make-up of natural microbial consortia. Apart from nucleic acid based approaches, community proteomics has the potential to provide a high-resolution representation of genotypic and phenotypic traits of distinct community memb...

journal_title：Current opinion in microbiology

authors： Wilmes P,Bond PL

更新日期：2009-06-01 00:00:00

abstract：:Mycobacterium tuberculosis, the causative agent of human tuberculosis is one of the most widely spread human pathogens. It has succeeded to infect a quarter of the global human population by developing most sophisticated ways to circumvent innate and adaptive immune defences. This highly specialized, major human patho...

journal_title：Current opinion in microbiology

authors： Orgeur M,Brosch R

更新日期：2018-02-01 00:00:00

abstract：:The human body comprises of micro-ecosystem made up of trillions of microbes (i.e. bacteria, archaea, fungi, protists and viruses). The total microbial gene content, which is referred to as the human microbiome, is fundamental to human physiology and immunity. There exists an intricate relationship between the surroun...

journal_title：Current opinion in microbiology

authors： Sharma A,Gilbert JA

更新日期：2018-08-01 00:00:00

abstract：:Bacterium-host interactions are important for diverse ecological settings including pathogenicity and symbiosis. Electron cryotomography is a powerful method for studying the macromolecular complexes that mediate such interactions in situ. The main limitation of electron cryotomography is its restriction to relatively...

journal_title：Current opinion in microbiology

authors： Medeiros JM,Böck D,Pilhofer M

更新日期：2018-06-01 00:00:00

abstract：:The Gram-positive pathogen Staphylococcus aureus poses a serious risk to public health due to its prevalence as a commensal organism, its ability to cause a multitude of diseases, and the increasing incidence of antibiotic resistant strains. S. aureus infects diverse niches within vertebrates despite being challenged ...

journal_title：Current opinion in microbiology

authors： Hammer ND,Skaar EP

更新日期：2012-02-01 00:00:00

abstract：:Single microbial cells can now be sequenced using DNA amplified by the Multiple Displacement Amplification (MDA) reaction. The few femtograms of DNA in a bacterium are amplified into micrograms of high molecular weight DNA suitable for DNA library construction and Sanger sequencing. The MDA-generated DNA also performs...

journal_title：Current opinion in microbiology

authors： Lasken RS

更新日期：2007-10-01 00:00:00

abstract：:Schizosaccharomyces pombe is a useful model system for understanding many aspects of eukaryotic cell growth. Studies of S. pombe have identified novel genes that function in the regulation of iron homeostasis. In response to high levels of iron, Fep1 represses the expression of several genes involved in the acquisitio...

journal_title：Current opinion in microbiology

authors： Labbé S,Khan MG,Jacques JF

更新日期：2013-12-01 00:00:00

abstract：:Antibiotic lethality is a complex physiological process, sensitive to external cues. Recent advances using systems approaches have revealed how events downstream of primary target inhibition actively participate in antibiotic death processes. In particular, altered metabolism, translational stress and DNA damage each ...

journal_title：Current opinion in microbiology

authors： Yang JH,Bening SC,Collins JJ

更新日期：2017-10-01 00:00:00

abstract：:The skin is our first line of defense, protecting us from invasion and evaporation. Its variable structure, changing geography, and complex immune repertoire provide a vast interface for our cutaneous microbial community. Skin is inhabited by many thousands of microbes, but this review focuses on the dominant eukaryot...

journal_title：Current opinion in microbiology

authors： Grice EA,Dawson TL 23⁎Jr

更新日期：2017-12-01 00:00:00

abstract：:Trypanosomes and Leishmania contain an abundance of stage-regulated cysteine proteinases encoded by several gene families. Analysis of parasites rendered defective in cysteine proteinase function, either through genetic manipulation or through the use of specific inhibitors, has revealed roles for the enzymes in paras...

journal_title：Current opinion in microbiology

authors： Mottram JC,Brooks DR,Coombs GH

更新日期：1998-08-01 00:00:00

abstract：:Nucleoid proteins are a group of abundant DNA binding proteins that modulate the structure of the bacterial chromosome. They have been recruited as specific negative and positive regulators of gene transcription and their fluctuating patterns of expression are often exploited to impart an additional level of control w...

journal_title：Current opinion in microbiology

authors： McLeod SM,Johnson RC

更新日期：2001-04-01 00:00:00

abstract：:The post-translational attachment of ubiquitin or ubiquitin-like modifiers (ULMs) to proteins regulates many cellular processes including the generation of innate and adaptive immune responses to pathogens. Vice versa, pathogens counteract immune defense by inhibiting or redirecting the ubiquitination machinery of the...

journal_title：Current opinion in microbiology

authors： Viswanathan K,Früh K,DeFilippis V

更新日期：2010-08-01 00:00:00

abstract：:Wastewater bioreactors have been used to treat domestic and industrial waste for nearly a century. Development of molecular tools such as PCR and DNA microarrays have enabled identification and characterization of some of the microbes in these bioreactors; however, molecular characterization of the microbes is still i...

journal_title：Current opinion in microbiology

authors： Bramucci M,Nagarajan V

更新日期：2006-06-01 00:00:00

abstract：:Photodynamic therapy (PDT) uses photosensitizers (non-toxic dyes) that are activated by absorption of visible light to form reactive oxygen species (including singlet oxygen) that can oxidize biomolecules and destroy cells. Antimicrobial photodynamic inactivation (aPDI) can treat localized infections. aPDI neither cau...

journal_title：Current opinion in microbiology

authors： Hamblin MR

更新日期：2016-10-01 00:00:00

abstract：:The concept of 'protein function' is rather 'fuzzy' because it is often based on whimsical terms or contradictory nomenclature. This currently presents a challenge for functional genomics because precise definitions are essential for most computational approaches. Addressing this challenge, the notion of networks betw...

journal_title：Current opinion in microbiology

authors： Jansen R,Gerstein M

更新日期：2004-10-01 00:00:00

abstract：:Intracellular bacteria in mammalian host cells can either live in a membrane-bound vacuole modified to support bacterial growth, or escape from the primary phagosome into the host cell cytoplasm. Phagosomal escape is best studied in Listeria monocytogenes in which a pore-forming cytolysin and two phospholipases are in...

journal_title：Current opinion in microbiology

authors： Goebel W,Kuhn M

更新日期：2000-02-01 00:00:00

abstract：:High-throughput identification of proteins and their accurate partial sequencing by shotgun nanoLC-MS/MS are now feasible for any cellular model at a full genomic scale. Proteogenomics is the integration of these data with the genome. Mining microbial proteomes allows validation of predicted orphan genes and correctio...

journal_title：Current opinion in microbiology

authors： Armengaud J

更新日期：2009-06-01 00:00:00

abstract：:The therapeutic landscape for mycotic infections is shifting. New generation azoles that are active against clinically relevant, drug-resistant fungal pathogens have improved bioavailability, half-lives and safety profiles. Acylated cyclic peptide inhibitors of beta(1,3)glucan synthesis with origins as fungal metaboli...

journal_title：Current opinion in microbiology

authors： Tkacz JS,DiDomenico B

更新日期：2001-10-01 00:00:00

abstract：:Antibiotics started to be used almost 90 years ago to eradicate life-threatening infections. The urgency of the problem required rapid, broad-spectrum elimination of infectious agents. Since their initial discovery, these antimicrobials have saved millions of lives. However, they are not exempt from side effects, whic...

journal_title：Current opinion in microbiology

authors： de la Fuente-Nunez C,Torres MD,Mojica FJ,Lu TK

更新日期：2017-06-01 00:00:00

abstract：:The family Arenaviridae consists of a unique genus (Arenavirus) that currently comprises 22 viral species, as recognized by the International Committee for Taxonomy of Viruses. Seven newly discovered represent putative new species. Here, our aims were to provide the most comprehensive phylogenetic analysis of members ...

journal_title：Current opinion in microbiology

authors： Charrel RN,de Lamballerie X,Emonet S

更新日期：2008-08-01 00:00:00

abstract：:Complete and partial genome sequence information is underway in several parasitic and symbiotic fungi that infect humans, other animals and plants. Comparative analyses of these sequences will provide new insights into the genomic plasticity and evolution of parasitism and mutualism in fungi. ...

journal_title：Current opinion in microbiology

authors： Tunlid A,Talbot NJ

更新日期：2002-10-01 00:00:00

abstract：:Since the publication of the complete genome sequence of Mycobacterium tuberculosis in 1998, there has been a marked intensification and diversification of activities in the field of tuberculosis research. Among the areas that have advanced spectacularly are comparative genomics, functional genomics-notably the study ...

journal_title：Current opinion in microbiology

authors： Domenech P,Barry CE 3rd,Cole ST

更新日期：2001-02-01 00:00:00

abstract：:Dictyostelium genome sequencing predicts an unexpectedly large number of genes. Many are absent from yeast but present in animals and presumably support cellular abilities not found in yeast. Prominent amongst these abilities is chemotaxis, where great strides are being made in understanding how cells orient in a grad...

journal_title：Current opinion in microbiology

authors： Kay RR

更新日期：2002-12-01 00:00:00

abstract：:One defining feature of apicomplexan parasites is their special ability to actively invade host cells. Although rapid, invasion is a complicated process that requires coordinated activities of host cell attachment, protein secretion, and motility by the parasite. Central to this process is the establishment of a struc...

journal_title：Current opinion in microbiology

authors： Shen B,Sibley LD

更新日期：2012-08-01 00:00:00

abstract：:Much of what we know about cytokinesis in bacteria has come from studies with Escherichia coli, and efforts to comprehensively understand this fundamental process in this organism continue to intensify. Major recent advances include in vitro assembly of a membrane-tethered version of FtsZ into contractile rings in lip...

journal_title：Current opinion in microbiology

authors： de Boer PA

更新日期：2010-12-01 00:00:00