Abstract：
:Antibiotics started to be used almost 90 years ago to eradicate life-threatening infections. The urgency of the problem required rapid, broad-spectrum elimination of infectious agents. Since their initial discovery, these antimicrobials have saved millions of lives. However, they are not exempt from side effects, which include the indiscriminate disruption of the beneficial microbiota. Recent technological advances have enabled the development of antimicrobials that can selectively target a gene, a cellular process, or a microbe of choice. These strategies bring us a step closer to developing personalized therapies that exclusively remove disease-causing infectious agents. Here, we advocate the preservation of our beneficial microbes and provide an overview of promising alternatives to broad-spectrum antimicrobials. Specifically, we emphasize nucleic acid and peptide-based systems as a foundation for next-generation alternatives to antibiotics that do not challenge our microbiota and may help to mitigate the spread of resistance.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
de la Fuente-Nunez C,Torres MD,Mojica FJ,Lu TKdoi
10.1016/j.mib.2017.05.014subject
Has Abstractpub_date
2017-06-01 00:00:00pages
95-102eissn
1369-5274issn
1879-0364pii
S1369-5274(17)30048-6journal_volume
37pub_type
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
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journal_title：Current opinion in microbiology
pub_type： 杂志文章,评审
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