Genomics and computational molecular biology.

Abstract:

:There has been a dramatic increase in the number of completely sequenced bacterial genomes during the past two years as a result of the efforts both of public genome agencies and the pharmaceutical industry. The availability of completely sequenced genomes permits more systematic analyses of genes, evolution and genome function than was otherwise possible. Using computational methods - which are used to identify genes and their functions including statistics, sequence similarity, motifs, profiles, protein folds and probabilistic models - it is possible to develop characteristic genome signatures, assign functions to genes, identify pathogenic genes, identify metabolic pathways, develop diagnostic probes and discover potential drug-binding sites. All of these directions are critical to understanding bacterial growth, pathogenicity and host-pathogen interactions.

journal_name

Curr Opin Microbiol

authors

Brutlag DL

doi

10.1016/s1369-5274(98)80039-8

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

340-5

issue

3

eissn

1369-5274

issn

1879-0364

pii

S1369-5274(98)80039-8

journal_volume

1

pub_type

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