Abstract:
:Virulence gene regulators RovA, SlyA and PecS comprise a subset of the MarR/SlyA family of transcriptional regulators, which has been shown to be involved in the regulation of virulence genes. These regulators have all been shown to both positively and negatively regulate the expression of multiple genes, involving several different mechanisms. One of the conserved mechanisms of regulatory control among these proteins appears to be competition for binding sites with other proteins. SlyA negatively regulates its own expression by interfering with the binding of RNA polymerase, whereas RovA appears to interfere with the progression of RNA polymerase from its promoter and to compete for binding with the heat-stable nucleoid-structural protein (H-NS), a global transcriptional silencer. PecS represses transcription by competing for binding with cAMP receptor protein, a global activator. RovA, SlyA and PecS have all been shown to act as derepressors by competing for binding sites with repressors. Recently, RovA also was found to enhance transcription through interaction with RNA polymerase.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Ellison DW,Miller VLdoi
10.1016/j.mib.2006.02.003subject
Has Abstractpub_date
2006-04-01 00:00:00pages
153-9issue
2eissn
1369-5274issn
1879-0364pii
S1369-5274(06)00023-3journal_volume
9pub_type
杂志文章,评审abstract::Single microbial cells can now be sequenced using DNA amplified by the Multiple Displacement Amplification (MDA) reaction. The few femtograms of DNA in a bacterium are amplified into micrograms of high molecular weight DNA suitable for DNA library construction and Sanger sequencing. The MDA-generated DNA also performs...
journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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pub_type: 杂志文章,评审
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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doi:10.1016/j.mib.2004.06.002
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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