HIV-host interactions: vital to the virus and key to its inhibition.

abstract：:Bacteria utilize a diverse set of nucleotide second messengers to regulate cellular responses by binding macromolecular receptors (RNAs and proteins). Recent studies on cyclic di-GMP (c-di-GMP) have shown that this signaling molecule binds multiple receptors to regulate different steps in the same biological process. ...

journal_title：Current opinion in microbiology

authors： Orr MW,Galperin MY,Lee VT

更新日期：2016-12-01 00:00:00

abstract：:An understanding of the molecular bases of pathogenicity in Blastomyces dermatitidis and related systemic dimorphic fungi has been limited until recent years. Yeast cells of B. dermatitidis display an adhesion promoting protein termed WI-1. Recent studies entailing homologous gene targeting and mutation of WI-1 have p...

journal_title：Current opinion in microbiology

authors： Klein BS

更新日期：2000-08-01 00:00:00

abstract：:The protozoan parasite Trypanosoma brucei is the causative agent of African sleeping sickness and the wasting disease, nagana, in cattle. The parasite is transmitted to the mammalian host by the bite of a tsetse fly. These parasites lack transcriptional regulation, and their gene expression is mainly regulated post-tr...

journal_title：Current opinion in microbiology

authors： Michaeli S

更新日期：2014-08-01 00:00:00

abstract：:Natural products are a rich source of bioactive compounds that have been used successfully in the areas of human health from infectious disease to cancer; however, traditional fermentation-based screening has provided diminishing returns over the last 20-30 years. Solutions to the unmet need of resistant bacterial inf...

journal_title：Current opinion in microbiology

authors： Foulston L

更新日期：2019-10-01 00:00:00

abstract：:Chemical communication between cells ensures coordination of behavior. In prokaryotes, this chemical communication is usually referred to as quorum sensing, while eukaryotic cells signal through hormones. In the past years, a growing number of reports have shown that bacterial quorum sensing signals, called autoinduce...

journal_title：Current opinion in microbiology

authors： Pacheco AR,Sperandio V

更新日期：2009-04-01 00:00:00

abstract：:We postulate that phenotypic resistance to antibiotics, persistence, is not an evolved (selected-for) character but rather like mutation, an inadvertent product of different kinds of errors and glitches. The rate of generation of these errors is augmented by exposure to these drugs. The genes that have been identified...

journal_title：Current opinion in microbiology

authors： Levin BR,Concepción-Acevedo J,Udekwu KI

更新日期：2014-10-01 00:00:00

abstract：:The détente between pathogen and host has been of keen interest to researchers in spite of being exceedingly difficult to probe. Recently, new RNA interference (RNAi) technologies, in particular in Drosophila tissue culture cells, have made it possible to interrogate the genetics of host organisms rapidly, with nearly...

journal_title：Current opinion in microbiology

authors： Cherry S

更新日期：2008-06-01 00:00:00

abstract：:In contrast to obligate pathogens opportunistic pathogens such as Aspergillus fumigatus do not need a specific host to propagate or survive. However several characteristics of the saprophytic life-style and the selective pressure encountered in the primary ecological niche contribute to the virulence of A. fumigatus. ...

journal_title：Current opinion in microbiology

authors： Blatzer M,Latgé JP

更新日期：2017-12-01 00:00:00

abstract：:All organisms must secure essential trace nutrients, including iron, zinc, manganese and copper for survival and proliferation. However, these very nutrients are also highly toxic if present at elevated levels. Mammalian immunity has harnessed both the essentiality and toxicity of micronutrients to defend against micr...

journal_title：Current opinion in microbiology

authors： Ballou ER,Wilson D

更新日期：2016-08-01 00:00:00

abstract：:Leishmania parasites are able to delay the onset of cell-mediated immunity by selectively impairing the ability of infected macrophages to produce interleukin (IL)-12. Leishmania infection arrests the JAK/STAT-mediated signal transduction involved in activation of the IL-12 p40 promoter; the phosphorylation defects ma...

journal_title：Current opinion in microbiology

authors： McDowell MA,Sacks DL

更新日期：1999-08-01 00:00:00

abstract：:Candida albicans is a regular member of the intestinal microbiota in the majority of the human population. This underscores C. albicans' adaptation to life in the intestine without inducing competitive interactions with other microbes, or immune responses detrimental to its survival. However, specific conditions such ...

journal_title：Current opinion in microbiology

authors： Kumamoto CA,Gresnigt MS,Hube B

更新日期：2020-08-01 00:00:00

abstract：:The proposed order Megavirales comprises the nucleocytoplasmic large DNA viruses (NCLDV), infecting a wide range of hosts. Over time, they co-evolved with different host cells, developing various strategies to penetrate them. Mimiviruses and other giant viruses enter cells through phagocytosis, while Marseillevirus an...

journal_title：Current opinion in microbiology

authors： Rodrigues RAL,Abrahão JS,Drumond BP,Kroon EG

更新日期：2016-06-01 00:00:00

abstract：:Bacterial shape has always been hypothesized to play an important role in the biology of a species and in the ability of certain bacteria to influence human health. The recent discovery of peptidoglycan hydrolases that modulate shape has now allowed this hypothesis to be addressed directly. Genetic, biochemical, and p...

journal_title：Current opinion in microbiology

authors： Frirdich E,Gaynor EC

更新日期：2013-12-01 00:00:00

abstract：:The three dimensional ultrastructure of cells and tissues comes to light with tomography. There is an inherent tension between representing molecular detail at the highest possible resolution, on one hand, and visualizing spatial relations between large organelles or even neighboring cells in large volumes, on the oth...

journal_title：Current opinion in microbiology

authors： Elbaum M

更新日期：2018-06-01 00:00:00

abstract：:One promise of synthetic biology is to provide solutions for biomedical and industrial problems by rational design of added functionality in living systems. Microbes are at the forefront of this biological engineering endeavor due to their general ease of handling and their relevance in many potential applications fro...

journal_title：Current opinion in microbiology

authors： Bittihn P,Din MO,Tsimring LS,Hasty J

更新日期：2018-10-01 00:00:00

abstract：:The inexorable rise in cases of tuberculosis worldwide, fuelled by the HIV epidemic, highlights the need for new drugs and particularly those that can shorten the duration of treatment. Clinical trials of existing broad-spectrum agents such as the fluoroquinolone moxifloxacin are proceeding, on the basis of efficacy i...

journal_title：Current opinion in microbiology

authors： Duncan K,Barry CE 3rd

更新日期：2004-10-01 00:00:00

abstract：:The genomic revolution is fully upon us in 2006 and the pace of discovery is set to accelerate with the emergence of ultra-high-throughput sequencing technologies. Our complete genome collection of bacteria and archaea continues to grow in number and diversity, as genome sequencing is applied to an array of new proble...

journal_title：Current opinion in microbiology

authors： Field D,Wilson G,van der Gast C

更新日期：2006-10-01 00:00:00

abstract：:According to a Pew Research study published in February 2015, there are 37 antibacterial programs currently in clinical trials in the United States. Protein structure-based methods for guiding small molecule design were used in at least 34 of these programs. Typically, this occurred at an early stage (drug discovery a...

journal_title：Current opinion in microbiology

authors： Staker BL,Buchko GW,Myler PJ

更新日期：2015-10-01 00:00:00

abstract：:The ongoing development of metagenomic approaches is providing the means to explore antibiotic resistance in nature and address questions that could not be answered previously with conventional culture-based strategies. The number of available environmental metagenomic sequence datasets is rapidly expanding and hencef...

journal_title：Current opinion in microbiology

authors： Monier JM,Demanèche S,Delmont TO,Mathieu A,Vogel TM,Simonet P

更新日期：2011-06-01 00:00:00

abstract：:Recent work has shown that Immunoglobulin-like (Ig-like) domains occur frequently on the surface of tailed dsDNA bacteriophages. Several of these Ig-like domains are added to bacteriophage structural proteins via programmed ribosomal frameshifts, and their evolutionary patterns suggest that they can be exchanged by ho...

journal_title：Current opinion in microbiology

authors： Fraser JS,Maxwell KL,Davidson AR

更新日期：2007-08-01 00:00:00

abstract：:In this review, we demonstrate how game theory can be a useful first step in modeling and understanding interactions among bacteria that produce and resist antibiotics. We introduce the basic features of evolutionary game theory and explore model microbial systems that correspond to some classical games. Each game dis...

journal_title：Current opinion in microbiology

authors： Conlin PL,Chandler JR,Kerr B

更新日期：2014-10-01 00:00:00

abstract：:High-throughput identification of proteins and their accurate partial sequencing by shotgun nanoLC-MS/MS are now feasible for any cellular model at a full genomic scale. Proteogenomics is the integration of these data with the genome. Mining microbial proteomes allows validation of predicted orphan genes and correctio...

journal_title：Current opinion in microbiology

authors： Armengaud J

更新日期：2009-06-01 00:00:00

abstract：:In response to starvation, myxobacteria build multicellular fruiting bodies that contain many thousands of cells and that have particular species-specific shapes. To coordinate fruiting body development, the myxobacterial cells signal to each other. The timing of and cellular responses to these signals help to give fo...

journal_title：Current opinion in microbiology

authors： Kaiser D

更新日期：1998-12-01 00:00:00

abstract：:Motile bacteria seek optimal living habitats by following gradients of attractant and repellent chemicals in their environment. The signaling machinery for these chemotactic behaviors, although assembled from just a few protein components, has extraordinary information-processing capabilities. Escherichia coli, the be...

journal_title：Current opinion in microbiology

authors： Parkinson JS,Ames P,Studdert CA

更新日期：2005-04-01 00:00:00

abstract：:Gene clusters contributing to processes such as cell growth and pathogenicity are often controlled by two-component signal transduction systems (TCSs). Specific inhibitors against TCS systems work differently from conventional antibiotics, and developing them into new drugs that are effective against various drug-resi...

journal_title：Current opinion in microbiology

authors： Gotoh Y,Eguchi Y,Watanabe T,Okamoto S,Doi A,Utsumi R

更新日期：2010-04-01 00:00:00

abstract：:The RNA chaperone protein Hfq is critical to the function of small, base pairing RNAs in many bacteria. In the past few years, structures and modeling of wild type Hfq and assays of various mutants have documented that the homohexameric Hfq ring can contact RNA at four sites (proximal face, distal face, rim and C-term...

journal_title：Current opinion in microbiology

authors： Updegrove TB,Zhang A,Storz G

更新日期：2016-04-01 00:00:00

abstract：:Intracellular bacteria in mammalian host cells can either live in a membrane-bound vacuole modified to support bacterial growth, or escape from the primary phagosome into the host cell cytoplasm. Phagosomal escape is best studied in Listeria monocytogenes in which a pore-forming cytolysin and two phospholipases are in...

journal_title：Current opinion in microbiology

authors： Goebel W,Kuhn M

更新日期：2000-02-01 00:00:00

abstract：:Photodynamic therapy (PDT) uses photosensitizers (non-toxic dyes) that are activated by absorption of visible light to form reactive oxygen species (including singlet oxygen) that can oxidize biomolecules and destroy cells. Antimicrobial photodynamic inactivation (aPDI) can treat localized infections. aPDI neither cau...

journal_title：Current opinion in microbiology

authors： Hamblin MR

更新日期：2016-10-01 00:00:00

abstract：:Host social interactions can provide multiple complex pathways for microbial transmission. Here, we suggest non-human primates as models to study the social transmission of commensal or mutualistic microbes due to their high sociality, wide range of group compositions and dominance structures, and diverse group intera...

journal_title：Current opinion in microbiology

authors： Kuthyar S,Manus MB,Amato KR

更新日期：2019-08-01 00:00:00

abstract：:N(6)-methyl-adenines can serve as epigenetic signals for interactions between regulatory DNA sequences and regulatory proteins that control cellular functions, such as the initiation of chromosome replication or the expression of specific genes. Several of these genes encode master regulators of the bacterial cell cyc...

journal_title：Current opinion in microbiology

authors： Collier J

更新日期：2009-12-01 00:00:00