Eco-Aging: stem cells and microbes are controlled by aging antagonist FoxO.

Abstract:

:The review highlights the dual role that the conserved master regulator FoxO has in aging by coordinating both stem cell proliferation and antimicrobial peptides, effector molecules of the innate immune system. As observed in non-senescent Hydra, continuously high activity of the transcription factor FoxO contributes to continuous stem cell proliferation and could support robust colonization of epithelia with a stable microbiome. The integration of research from stem cell biology, microbiology and ecology into aging concepts (Eco-Aging) acknowledges the multi-organismic nature of all living beings and presents a new conceptual framework for explaining the process of aging.

journal_name

Curr Opin Microbiol

authors

Mortzfeld BM,Bosch TC

doi

10.1016/j.mib.2017.06.009

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

181-187

eissn

1369-5274

issn

1879-0364

pii

S1369-5274(17)30047-4

journal_volume

38

pub_type

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