Eco-Aging: stem cells and microbes are controlled by aging antagonist FoxO.


:The review highlights the dual role that the conserved master regulator FoxO has in aging by coordinating both stem cell proliferation and antimicrobial peptides, effector molecules of the innate immune system. As observed in non-senescent Hydra, continuously high activity of the transcription factor FoxO contributes to continuous stem cell proliferation and could support robust colonization of epithelia with a stable microbiome. The integration of research from stem cell biology, microbiology and ecology into aging concepts (Eco-Aging) acknowledges the multi-organismic nature of all living beings and presents a new conceptual framework for explaining the process of aging.


Curr Opin Microbiol


Mortzfeld BM,Bosch TC




Has Abstract


2017-08-01 00:00:00












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    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Rohde JR,Bastidas R,Puria R,Cardenas ME

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    journal_title:Current opinion in microbiology

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    authors: Dufrêne YF

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    journal_title:Current opinion in microbiology

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    authors: Armengaud J

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    pub_type: 杂志文章,评审


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    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Otto M

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    pub_type: 杂志文章,评审


    authors: Daher W,Soldati-Favre D

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    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Stepanauskas R

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  • Gene expression in Kinetoplastids.

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    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


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    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


    authors: Domenech P,Barry CE 3rd,Cole ST

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