Microbial diversity of hypersaline environments: a metagenomic approach.

abstract：:Biochemical, serological and microbiological methods have been used to dissect pathogens and identify the components useful for vaccine development. Although successful in many cases, this approach is time-consuming and fails when the pathogens cannot be cultivated in vitro, or when the most abundant antigens are vari...

journal_title：Current opinion in microbiology

authors： Rappuoli R

更新日期：2000-10-01 00:00:00

abstract：:Cryptosporidium is a leading cause of diarrhea and death in young children and untreated AIDS patients in resource-poor settings, and of waterborne outbreaks of disease in developed countries. However, there is no consistently effective treatment for vulnerable populations. Progress towards development of therapeutics...

journal_title：Current opinion in microbiology

authors： Bhalchandra S,Lamisere H,Ward H

更新日期：2020-12-01 00:00:00

abstract：:According to a Pew Research study published in February 2015, there are 37 antibacterial programs currently in clinical trials in the United States. Protein structure-based methods for guiding small molecule design were used in at least 34 of these programs. Typically, this occurred at an early stage (drug discovery a...

journal_title：Current opinion in microbiology

authors： Staker BL,Buchko GW,Myler PJ

更新日期：2015-10-01 00:00:00

abstract：:In Myxococcus xanthus morphogenetic cell movements constitute the basis for the formation of spreading vegetative colonies and fruiting bodies in starving cells. M. xanthus cells move by gliding and gliding motility depends on two polarly localized engines, type IV pili pull cells forward, and slime extruding nozzle-l...

journal_title：Current opinion in microbiology

authors： Søgaard-Andersen L

更新日期：2004-12-01 00:00:00

abstract：:Candida albicans is a regular member of the intestinal microbiota in the majority of the human population. This underscores C. albicans' adaptation to life in the intestine without inducing competitive interactions with other microbes, or immune responses detrimental to its survival. However, specific conditions such ...

journal_title：Current opinion in microbiology

authors： Kumamoto CA,Gresnigt MS,Hube B

更新日期：2020-08-01 00:00:00

abstract：:Translation of the genome into the proteome is a highly accurate biological process. However, the molecular mechanisms involved in protein synthesis are not error free and downstream protein quality control systems are needed to counteract the negative effects of translational errors (mistranslation) on proteome and c...

journal_title：Current opinion in microbiology

authors： Moura GR,Carreto LC,Santos MA

更新日期：2009-12-01 00:00:00

abstract：:Following concerns over the potential for insect resistance to insecticidal Bacillus thuringiensis toxins expressed in transgenic plants, there has been recent interest in novel biological insecticides. Over the past year there has been considerable progress in the cloning of several alternative toxin genes from the b...

journal_title：Current opinion in microbiology

authors： ffrench-Constant R,Bowen D

更新日期：1999-06-01 00:00:00

abstract：:Infections caused by the apicomplexan parasites Plasmodium and Toxoplasma are wide-spread, life-threatening and therapeutically challenging. These pathogens are obligate intracellular microorganisms that invade mammalian cells by forming a self-made niche, the parasitophorous vacuole that is impervious to host lysosom...

journal_title：Current opinion in microbiology

authors： Coppens I

更新日期：2017-12-01 00:00:00

abstract：:The eukaryotic unicellular pathogen Plasmodium falciparum tightly regulates gene expression, both during development and in adaptation to dynamic host environments. This regulation is evident in the mutually exclusive expression of members of clonally variant virulence multigene families. While epigenetic regulators h...

journal_title：Current opinion in microbiology

authors： Vembar SS,Scherf A,Siegel TN

更新日期：2014-08-01 00:00:00

abstract：:Natural products are a rich source of bioactive compounds that have been used successfully in the areas of human health from infectious disease to cancer; however, traditional fermentation-based screening has provided diminishing returns over the last 20-30 years. Solutions to the unmet need of resistant bacterial inf...

journal_title：Current opinion in microbiology

authors： Foulston L

更新日期：2019-10-01 00:00:00

abstract：:Coxiella burnetii is a widespread zoonotic bacterial pathogen that causes human Q fever. In vivo, Coxiella displays a tropism for mononuclear phagocytes where it participates in biogenesis of a lysosome-like replication compartment to conduct its obligate intracellular lifestyle. Coxiella actively regulates multiple e...

journal_title：Current opinion in microbiology

authors： Voth DE,Heinzen RA

更新日期：2009-02-01 00:00:00

abstract：:The ability to control uptake across the mucosa and to protect the gut from harmful substances present in the lumen is defined as intestinal barrier function. Two routes are usually distinguished for transepithelial transport. The paracellular route allows the passage of ions and small molecules and is mainly regulate...

journal_title：Current opinion in microbiology

authors： Barreau F,Hugot JP

更新日期：2014-02-01 00:00:00

abstract：:N(6)-methyl-adenines can serve as epigenetic signals for interactions between regulatory DNA sequences and regulatory proteins that control cellular functions, such as the initiation of chromosome replication or the expression of specific genes. Several of these genes encode master regulators of the bacterial cell cyc...

journal_title：Current opinion in microbiology

authors： Collier J

更新日期：2009-12-01 00:00:00

abstract：:Bacteria furnish tractable models for complex biological processes, and morphogenesis is now taking its turn. We can already explain in general terms how such elementary forms as rods and cocci are produced, and the shapes of several individual organisms are coming into focus. In most bacteria shape is maintained by t...

journal_title：Current opinion in microbiology

authors： Harold FM

更新日期：2007-12-01 00:00:00

abstract：:Recent developments have increased our understanding of the evolution of mutualistic associations between Epichloë endophytes and their grass hosts. Most of the asexual species appear to be interspecific hybrids. Although endophytes form compatible associations with their natural hosts, transfers to other hosts elicit...

journal_title：Current opinion in microbiology

authors： Scott B

更新日期：2001-08-01 00:00:00

abstract：:Major advances have been made in the past five years in the identification of cellular targets of toxins produced by anaerobic bacteria. These targets include the vesicular membrane docking and fusion apparatus, the actin cytoskeleton, the signal transduction machinery and the cell membrane. The recent discovery that ...

journal_title：Current opinion in microbiology

authors： Boquet P,Munro P,Fiorentini C,Just I

更新日期：1998-02-01 00:00:00

abstract：:In filamentous fungi, the actin cytoskeleton is required for polarity establishment and maintenance at hyphal tips and for formation of a contractile ring at sites of septation. Recently, formins have been identified as Arp (actin-related protein) 2/3-independent nucleators of actin polymerization, and filamentous fun...

journal_title：Current opinion in microbiology

authors： Xiang X,Plamann M

更新日期：2003-12-01 00:00:00

abstract：:Xenogeneic silencing proteins facilitate horizontal gene transfer by silencing expression of AT-rich sequences. By virtue of their activity these proteins serve as master regulators of a variety of important functions including motility, drug resistance, and virulence. Three families of silencers have been identified ...

journal_title：Current opinion in microbiology

authors： Ali SS,Xia B,Liu J,Navarre WW

更新日期：2012-04-01 00:00:00

abstract：:The proposed order Megavirales comprises the nucleocytoplasmic large DNA viruses (NCLDV), infecting a wide range of hosts. Over time, they co-evolved with different host cells, developing various strategies to penetrate them. Mimiviruses and other giant viruses enter cells through phagocytosis, while Marseillevirus an...

journal_title：Current opinion in microbiology

authors： Rodrigues RAL,Abrahão JS,Drumond BP,Kroon EG

更新日期：2016-06-01 00:00:00

abstract：:For many Gram-negative bacteria, like Brucella, the type IV secretion system (T4SS) has a critical role in bacterial virulence. In Brucella, the VirB T4SS permits the injection of bacterial effectors inside host cells, leading to subversion of signaling pathways and favoring bacterial growth and pathogenesis. The virB...

journal_title：Current opinion in microbiology

authors： Lacerda TL,Salcedo SP,Gorvel JP

更新日期：2013-02-01 00:00:00

abstract：:Application of metagenomic functional selections to study antibiotic resistance genes is revealing a highly diverse and complex network of genetic exchange between bacterial pathogens and environmental reservoirs, which likely contributes significantly to increasing resistance levels in pathogens. In some cases, clini...

journal_title：Current opinion in microbiology

authors： Dantas G,Sommer MO

更新日期：2012-10-01 00:00:00

abstract：:Extracytoplasmic function σ factors (ECFs) represent a fundamental and widely distributed principle of bacterial signal transduction that connects the perception of a stimulus (input) with the induction of an appropriate set of genes (output). In recent years, comparative genomics analyses have not only allowed a syst...

journal_title：Current opinion in microbiology

authors： Mascher T

更新日期：2013-04-01 00:00:00

abstract：:The détente between pathogen and host has been of keen interest to researchers in spite of being exceedingly difficult to probe. Recently, new RNA interference (RNAi) technologies, in particular in Drosophila tissue culture cells, have made it possible to interrogate the genetics of host organisms rapidly, with nearly...

journal_title：Current opinion in microbiology

authors： Cherry S

更新日期：2008-06-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a clinically significant herpes virus that maintains a lifelong infection in the host. HCMV infection of endothelial cells and macrophages plays an important role in the establishment of latency and persistence, which appears critical for the maintenance of HCMV within the host. HCMV in...

journal_title：Current opinion in microbiology

authors： Jarvis MA,Nelson JA

更新日期：2002-08-01 00:00:00

abstract：:Mosquitoes are the major arthropod vectors of human diseases such as malaria and viral encephalitis. However, each mosquito species does not transmit every pathogen, owing to reasons that include specific evolutionary histories, mosquito immune system structure, and ecology. Even a competent vector species for a patho...

journal_title：Current opinion in microbiology

authors： Mitri C,Vernick KD

更新日期：2012-06-01 00:00:00

abstract：:Recent studies have led to the identification of more than 50 small regulatory RNAs in Escherichia coli. Only a subset of these RNAs has been characterized. However, it is clear that many of the RNAs, such as the MicF, OxyS, DsrA, Spot42 and RyhB RNAs, act by basepairing to activate or repress translation or to destab...

journal_title：Current opinion in microbiology

authors： Storz G,Opdyke JA,Zhang A

更新日期：2004-04-01 00:00:00

abstract：:The small nucleotides pppGpp and ppGpp (or (p)ppGpp) are rapidly synthesized in response to nutritional stress. In Escherichia coli, the enzymes RelA and SpoT are triggered by different starvation signals to produce (p)ppGpp. In many Gram-positive bacteria this is carried out by RelA and two small homologs. (p)ppGpp, ...

journal_title：Current opinion in microbiology

authors： Srivatsan A,Wang JD

更新日期：2008-04-01 00:00:00

abstract：:Single microbial cells can now be sequenced using DNA amplified by the Multiple Displacement Amplification (MDA) reaction. The few femtograms of DNA in a bacterium are amplified into micrograms of high molecular weight DNA suitable for DNA library construction and Sanger sequencing. The MDA-generated DNA also performs...

journal_title：Current opinion in microbiology

authors： Lasken RS

更新日期：2007-10-01 00:00:00

abstract：:Small RNAs can act to regulate both the synthesis of proteins, by affecting mRNA transcription, translation and stability, and the activity of specific proteins by binding to them. As a result of recent genome-wide screens, around 50 small RNAs have now been identified in Escherichia coli. These include many that requ...

journal_title：Current opinion in microbiology

authors： Massé E,Majdalani N,Gottesman S

更新日期：2003-04-01 00:00:00

abstract：:High throughput, deep sequencing assays are powerful tools for gaining insights into virus-host interactions. Sequencing assays can discover novel viruses and describe the genomes of novel and known viruses. Genomic information can predict viral proteins that can be characterized, describe important genes in the host ...

journal_title：Current opinion in microbiology

authors： Wylie KM,Weinstock GM,Storch GA

更新日期：2013-08-01 00:00:00