Abstract:
:Application of metagenomic functional selections to study antibiotic resistance genes is revealing a highly diverse and complex network of genetic exchange between bacterial pathogens and environmental reservoirs, which likely contributes significantly to increasing resistance levels in pathogens. In some cases, clinically relevant resistance genes have been acquired from organisms where their native function is not antibiotic resistance, and which may not even confer a resistance phenotype in their native context. In this review, we attempt to distinguish the resistance phenotype from the resistome genotype, and we highlight examples of genes and their hosts where this distinction becomes important in order to understand the relevance of environmental niches that contribute most to clinical problems associated with antibiotic resistance.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Dantas G,Sommer MOdoi
10.1016/j.mib.2012.07.004subject
Has Abstractpub_date
2012-10-01 00:00:00pages
577-82issue
5eissn
1369-5274issn
1879-0364pii
S1369-5274(12)00092-6journal_volume
15pub_type
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