YidC--an evolutionary conserved device for the assembly of energy-transducing membrane protein complexes.


:Members of the YidC/Oxa1/Alb3 membrane protein family are multifunctional mediators of membrane protein integration, folding and assembly into large complexes. Their evolutionary conserved and physiologically important role appears to relate to the assembly of major energy-transducing membrane protein complexes.


Curr Opin Microbiol


van der Laan M,Nouwen NP,Driessen AJ




Has Abstract


2005-04-01 00:00:00














  • Flexible genomic islands as drivers of genome evolution.

    abstract::Natural prokaryotic populations are composed of multiple clonal lineages that are different in their core genomes in a range that varies typically between 95 and 100% nucleotide identity. Each clonal lineage also carries a complement of not shared flexible genes that can be very large. The compounded flexible genome p...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Rodriguez-Valera F,Martin-Cuadrado AB,López-Pérez M

    更新日期:2016-06-01 00:00:00

  • Mechanisms of stabilization of integrative and conjugative elements.

    abstract::Integrative and conjugative elements (ICEs) are nearly ubiquitous in microbial genomes and influence their evolution by providing adaptive functions to their host and by enhancing genome plasticity and diversification. For a long-time, it has been assumed that by integrating into the chromosome of their host, these se...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Burrus V

    更新日期:2017-08-01 00:00:00

  • Genomic RNAi screening in Drosophila S2 cells: what have we learned about host-pathogen interactions?

    abstract::The détente between pathogen and host has been of keen interest to researchers in spite of being exceedingly difficult to probe. Recently, new RNA interference (RNAi) technologies, in particular in Drosophila tissue culture cells, have made it possible to interrogate the genetics of host organisms rapidly, with nearly...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Cherry S

    更新日期:2008-06-01 00:00:00

  • Two's company: studying interspecies relationships with dual RNA-seq.

    abstract::Organisms do not exist isolated from each other, but constantly interact. Cells can sense the presence of interaction partners by a range of receptors and, via complex regulatory networks, specifically react by changing the expression of many of their genes. Technological advances in next-generation sequencing over th...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Wolf T,Kämmer P,Brunke S,Linde J

    更新日期:2018-04-01 00:00:00

  • Bacterial replication in the host cell cytosol.

    abstract::Intracellular bacteria in mammalian host cells can either live in a membrane-bound vacuole modified to support bacterial growth, or escape from the primary phagosome into the host cell cytoplasm. Phagosomal escape is best studied in Listeria monocytogenes in which a pore-forming cytolysin and two phospholipases are in...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Goebel W,Kuhn M

    更新日期:2000-02-01 00:00:00

  • Striking a balance: fungal commensalism versus pathogenesis.

    abstract::The environment is suffused with nearly countless types of fungi, and our immune systems must be tuned to cope with constant exposure to them. In addition, it is becoming increasingly clear that many surfaces of our bodies are colonized with complex populations of fungi (the mycobiome) in the same way that they are co...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Iliev ID,Underhill DM

    更新日期:2013-06-01 00:00:00

  • An evolutionary perspective on the broad antiviral specificity of MxA.

    abstract::Germ line encoded antiviral defenses in vertebrate cells tend to be either broadly acting factors that exploit general features of viral replication or effectors with strong pathogen preference by virtue of specific recognition of viral proteins. The Mx GTPases, however, are atypical since they have broad antiviral ac...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Mitchell PS,Emerman M,Malik HS

    更新日期:2013-08-01 00:00:00

  • The coming of age of niche vaccines? Effect of vaccines on resistance profiles in Streptococcus pneumoniae.

    abstract::Pneumococcal conjugate vaccine is not only effective against invasive and non-invasive disease in all ages but also has a significant impact on antibiotic-resistant infections since a number of resistant serotypes are targeted by the vaccine. Surveillance studies in the post-licensure years have shown an increase in n...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: McGee L

    更新日期:2007-10-01 00:00:00

  • Iron uptake and regulation in Schizosaccharomyces pombe.

    abstract::Schizosaccharomyces pombe is a useful model system for understanding many aspects of eukaryotic cell growth. Studies of S. pombe have identified novel genes that function in the regulation of iron homeostasis. In response to high levels of iron, Fep1 represses the expression of several genes involved in the acquisitio...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Labbé S,Khan MG,Jacques JF

    更新日期:2013-12-01 00:00:00

  • Viral hijacking of the host ubiquitin system to evade interferon responses.

    abstract::The post-translational attachment of ubiquitin or ubiquitin-like modifiers (ULMs) to proteins regulates many cellular processes including the generation of innate and adaptive immune responses to pathogens. Vice versa, pathogens counteract immune defense by inhibiting or redirecting the ubiquitination machinery of the...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Viswanathan K,Früh K,DeFilippis V

    更新日期:2010-08-01 00:00:00

  • Targeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence.

    abstract::Some RNA virus genomes bear 5'-triphosphates, which can be recognized in the cytoplasm of infected cells by host proteins that mediate anti-viral immunity. Both the innate sensor RIG-I and the interferon-induced IFIT proteins bind to 5'-triphosphate viral RNAs. RIG-I signals for induction of interferons during RNA vir...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Rehwinkel J,Reis e Sousa C

    更新日期:2013-08-01 00:00:00

  • Brucella T4SS: the VIP pass inside host cells.

    abstract::For many Gram-negative bacteria, like Brucella, the type IV secretion system (T4SS) has a critical role in bacterial virulence. In Brucella, the VirB T4SS permits the injection of bacterial effectors inside host cells, leading to subversion of signaling pathways and favoring bacterial growth and pathogenesis. The virB...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Lacerda TL,Salcedo SP,Gorvel JP

    更新日期:2013-02-01 00:00:00

  • Emerging views on integrin signaling via Rac1 during invasin-promoted bacterial uptake.

    abstract::Enteropathogenic Yersinia species encode invasin, which promotes uptake into host cells by binding beta1 integrins. Invasin may cluster integrin heterodimers extracellularly and cause the integrin alpha and beta chains to splay apart in the cytoplasm. Cdc42 signaling is not essential for Yersinia uptake, whereas invas...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Wong KW,Isberg RR

    更新日期:2005-02-01 00:00:00

  • How bacteria talk to each other: regulation of gene expression by quorum sensing.

    abstract::Quorum sensing, or the control of gene expression in response to cell density, is used by both gram-negative and gram-positive bacteria to regulate a variety of physiological functions. In all cases, quorum sensing involves the production and detection of extracellular signalling molecules called autoinducers. While u...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Bassler BL

    更新日期:1999-12-01 00:00:00

  • The crucial role of iron uptake in Aspergillus fumigatus virulence.

    abstract::Aspergillus fumigatus is an opportunistic fungal pathogen that causes life-threatening infections in immunocompromised individuals. Siderophore-mediated iron acquisition has been shown to be essential for virulence. New studies have revealed that enzymes involved in siderophore biosynthesis and uptake are compartmenta...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Moore MM

    更新日期:2013-12-01 00:00:00

  • Immunoglobulin-like domains on bacteriophage: weapons of modest damage?

    abstract::Recent work has shown that Immunoglobulin-like (Ig-like) domains occur frequently on the surface of tailed dsDNA bacteriophages. Several of these Ig-like domains are added to bacteriophage structural proteins via programmed ribosomal frameshifts, and their evolutionary patterns suggest that they can be exchanged by ho...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Fraser JS,Maxwell KL,Davidson AR

    更新日期:2007-08-01 00:00:00

  • Tissue-specific cellular immune responses to malaria pre-erythrocytic stages.

    abstract::Complete and long-lasting protective immunity against malaria can be achieved through vaccination with invasive live attenuated Plasmodium sporozoites, the motile stage inoculated in the host skin during a mosquito bite. Protective immunity relies primarily on effector CD8+ T cells targeting the parasite in the liver....

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Silvie O,Amino R,Hafalla JC

    更新日期:2017-12-01 00:00:00

  • Bacterial morphogenesis: learning how cells make cells.

    abstract::Bacteria furnish tractable models for complex biological processes, and morphogenesis is now taking its turn. We can already explain in general terms how such elementary forms as rods and cocci are produced, and the shapes of several individual organisms are coming into focus. In most bacteria shape is maintained by t...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Harold FM

    更新日期:2007-12-01 00:00:00

  • Collaborative signaling by bacterial chemoreceptors.

    abstract::Motile bacteria seek optimal living habitats by following gradients of attractant and repellent chemicals in their environment. The signaling machinery for these chemotactic behaviors, although assembled from just a few protein components, has extraordinary information-processing capabilities. Escherichia coli, the be...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Parkinson JS,Ames P,Studdert CA

    更新日期:2005-04-01 00:00:00

  • Membrane trafficking and remodeling at the host-parasite interface.

    abstract::Membrane shape is functionally linked with many cellular processes. The limiting membrane of vacuoles containing Toxoplasma gondii and Plasmodium apicomplexan parasites lies at the host-parasite interface. This membrane comprises intra-vacuolar and extra-vacuolar tubulo-vesicular deformations, which influence host-par...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Santi-Rocca J,Blanchard N

    更新日期:2017-12-01 00:00:00

  • Synthetic microbial communities.

    abstract::While natural microbial communities are composed of a mix of microbes with often unknown functions, the construction of synthetic microbial communities allows for the generation of defined systems with reduced complexity. Used in a top-down approach, synthetic communities serve as model systems to ask questions about ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Grosskopf T,Soyer OS

    更新日期:2014-04-01 00:00:00

  • Superantigens of gram-positive bacteria: structure-function analyses and their implications for biological activity.

    abstract::Just as we thought that we know everything about superantigens, new molecular and structural studies indicate that we have only just begun to unravel the secrets of these fascinating molecules. Recent structure-function analysis of superantigens from Gram-positive bacteria, with emphasis on their interaction with majo...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Kotb M

    更新日期:1998-02-01 00:00:00

  • Bacterial solute uptake and efflux systems.

    abstract::The recent discovery of binding protein dependent secondary transporters and the ever-growing family of membrane potential generating secondary transporters emphasize the diversity of transport systems in both the mechanistical and physiological sense. The vast amount of data on the lactose permease is now beginning t...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Lolkema JS,Poolman B,Konings WN

    更新日期:1998-04-01 00:00:00

  • Cell division is dispensable but not irrelevant in Streptomyces.

    abstract::In part, members of the genus Streptomyces have been studied because they produce many important secondary metabolites with antibiotic activity and for the interest in their relatively elaborate life cycle. These sporulating filamentous bacteria are remarkably synchronous for division and genome segregation in special...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: McCormick JR

    更新日期:2009-12-01 00:00:00

  • Photorhabdus toxins: novel biological insecticides.

    abstract::Following concerns over the potential for insect resistance to insecticidal Bacillus thuringiensis toxins expressed in transgenic plants, there has been recent interest in novel biological insecticides. Over the past year there has been considerable progress in the cloning of several alternative toxin genes from the b...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: ffrench-Constant R,Bowen D

    更新日期:1999-06-01 00:00:00

  • Extracellular signaling and multicellularity in Bacillus subtilis.

    abstract::Bacillus subtilis regulates its ability to differentiate into distinct, co-existing cell types in response to extracellular signaling molecules produced either by itself, or present in its environment. The production of molecules by B. subtilis cells, as well as their response to these signals, is not uniform across t...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Shank EA,Kolter R

    更新日期:2011-12-01 00:00:00

  • Silencing of foreign DNA in bacteria.

    abstract::Xenogeneic silencing proteins facilitate horizontal gene transfer by silencing expression of AT-rich sequences. By virtue of their activity these proteins serve as master regulators of a variety of important functions including motility, drug resistance, and virulence. Three families of silencers have been identified ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Ali SS,Xia B,Liu J,Navarre WW

    更新日期:2012-04-01 00:00:00

  • Players between the worlds: multifunctional DNA translocases.

    abstract::DNA translocases play important roles during the bacterial cell cycle and in cell differentiation. Escherichia coli cells contain a multifunctional translocase, FtsK, which is involved in cell division, late steps of chromosome segregation and dimer resolution. In Gram-positive bacteria, the latter two processes are a...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Kaimer C,Graumann PL

    更新日期:2011-12-01 00:00:00

  • Control of bacterial colonization in the glands and crypts.

    abstract::The epithelial cell layer of the major organs of the mammalian gastrointestinal (GI) tract is extensively invaginated into thousands of gland and crypt structures. These are lined by distinct sets of epithelial cells and may comprise discrete niches. The host maximizes the distance between the epithelial cell layer an...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Yang C,Ottemann KM

    更新日期:2019-02-01 00:00:00

  • Growth rate and cell size: a re-examination of the growth law.

    abstract::Research into the mechanisms regulating bacterial cell size has its origins in a single paper published over 50 years ago. In it Schaechter and colleagues made the observation that the chemical composition and size of a bacterial cell is a function of growth rate, independent of the medium used to achieve that growth ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审


    authors: Vadia S,Levin PA

    更新日期:2015-04-01 00:00:00