Control of transcription by nucleoid proteins.

abstract：:Protozoan pathogens have evolved countermeasures to avoid immune clearance and prolong the period of infection in their vertebrate hosts. The type and degree of immune escape strategies depends on the in vivo 'lifestyle' the pathogen has adopted. Here we describe how parasites use different strategies to coordinate th...

journal_title：Current opinion in microbiology

authors： Lopez-Rubio JJ,Riviere L,Scherf A

更新日期：2007-12-01 00:00:00

abstract：:Recent studies on antibacterials have focused on the development of antimycobacterial agents and antibacterial peptides, and on furthering the understanding of agents that have been available for several decades, including imidazoles, beta-lactams and quinolones. New areas of research include antisense oligonucleotide...

journal_title：Current opinion in microbiology

authors： Piddock LJ

更新日期：1998-10-01 00:00:00

abstract：:Intracellular protozoans co-evolved with their mammalian host cells a range of strategies to cope with the composite and dynamic cell surface features they encounter during migration and infection. Therefore, these single-celled eukaryotic parasites represent a fascinating source of living probes for precisely capturi...

journal_title：Current opinion in microbiology

authors： Pavlou G,Milon G,Tardieux I

更新日期：2019-12-01 00:00:00

abstract：:An increasingly diverse array of clinically relevant animal models of candidiasis have been established that mimic both the immune perturbations of the host and tissue-specific features of candidiasis in humans. Cause-and-effect analysis of Candida host-pathogen interactions using these animal models has made a quantu...

journal_title：Current opinion in microbiology

authors： de Repentigny L

更新日期：2004-08-01 00:00:00

abstract：:A combination of structural, biochemical and functional studies with the flavivirus tick-borne encephalitis virus has revealed the characteristics of a new class of viral fusion protein, class II, that is unrelated to the class I viral fusion proteins for which influenza virus hemagglutinin is the prototype. New struc...

journal_title：Current opinion in microbiology

authors： Heinz FX,Allison SL

更新日期：2001-08-01 00:00:00

abstract：:The availability of genome information for microbial consortia, including unculturable species, from environmental samples has enabled systems-biology interrogation by providing a means to access genomic, transcriptomic, and proteomic information. This provides a unique opportunity to characterize the molecular activi...

journal_title：Current opinion in microbiology

authors： Hettich RL,Sharma R,Chourey K,Giannone RJ

更新日期：2012-06-01 00:00:00

abstract：:Antibiotics started to be used almost 90 years ago to eradicate life-threatening infections. The urgency of the problem required rapid, broad-spectrum elimination of infectious agents. Since their initial discovery, these antimicrobials have saved millions of lives. However, they are not exempt from side effects, whic...

journal_title：Current opinion in microbiology

authors： de la Fuente-Nunez C,Torres MD,Mojica FJ,Lu TK

更新日期：2017-06-01 00:00:00

abstract：:Sequestered from the action of complement, antibody and lytic peptides, phagosomal pathogens pose a unique problem for the innate immune system both in terms of detection and disposal. An immunologically induced 47-kDa (p47) GTPase family recruited to nascent phagosomes (PGs) has provided new insights into how vertebr...

journal_title：Current opinion in microbiology

authors： MacMicking JD

更新日期：2005-02-01 00:00:00

abstract：:Dictyostelium genome sequencing predicts an unexpectedly large number of genes. Many are absent from yeast but present in animals and presumably support cellular abilities not found in yeast. Prominent amongst these abilities is chemotaxis, where great strides are being made in understanding how cells orient in a grad...

journal_title：Current opinion in microbiology

authors： Kay RR

更新日期：2002-12-01 00:00:00

abstract：:Motile bacteria seek optimal living habitats by following gradients of attractant and repellent chemicals in their environment. The signaling machinery for these chemotactic behaviors, although assembled from just a few protein components, has extraordinary information-processing capabilities. Escherichia coli, the be...

journal_title：Current opinion in microbiology

authors： Parkinson JS,Ames P,Studdert CA

更新日期：2005-04-01 00:00:00

abstract：:Single microbial cells can now be sequenced using DNA amplified by the Multiple Displacement Amplification (MDA) reaction. The few femtograms of DNA in a bacterium are amplified into micrograms of high molecular weight DNA suitable for DNA library construction and Sanger sequencing. The MDA-generated DNA also performs...

journal_title：Current opinion in microbiology

authors： Lasken RS

更新日期：2007-10-01 00:00:00

abstract：:The détente between pathogen and host has been of keen interest to researchers in spite of being exceedingly difficult to probe. Recently, new RNA interference (RNAi) technologies, in particular in Drosophila tissue culture cells, have made it possible to interrogate the genetics of host organisms rapidly, with nearly...

journal_title：Current opinion in microbiology

authors： Cherry S

更新日期：2008-06-01 00:00:00

abstract：:One promise of synthetic biology is to provide solutions for biomedical and industrial problems by rational design of added functionality in living systems. Microbes are at the forefront of this biological engineering endeavor due to their general ease of handling and their relevance in many potential applications fro...

journal_title：Current opinion in microbiology

authors： Bittihn P,Din MO,Tsimring LS,Hasty J

更新日期：2018-10-01 00:00:00

abstract：:Aspergillus fumigatus is an opportunistic fungal pathogen that causes life-threatening infections in immunocompromised individuals. Siderophore-mediated iron acquisition has been shown to be essential for virulence. New studies have revealed that enzymes involved in siderophore biosynthesis and uptake are compartmenta...

journal_title：Current opinion in microbiology

authors： Moore MM

更新日期：2013-12-01 00:00:00

abstract：:Photodynamic therapy (PDT) uses photosensitizers (non-toxic dyes) that are activated by absorption of visible light to form reactive oxygen species (including singlet oxygen) that can oxidize biomolecules and destroy cells. Antimicrobial photodynamic inactivation (aPDI) can treat localized infections. aPDI neither cau...

journal_title：Current opinion in microbiology

authors： Hamblin MR

更新日期：2016-10-01 00:00:00

abstract：:Atomic force microscopy imaging and force spectroscopy have recently opened a range of novel applications in microbiology. During the past two years, rapid advances have been made using atomic force microscopy to visualize the surface structure of two-dimensional bacterial protein crystals, biofilms and individual cel...

journal_title：Current opinion in microbiology

authors： Dufrêne YF

更新日期：2003-06-01 00:00:00

abstract：:Environmental pathogenic fungi present a paradox in that they are virulent in animals without requiring animal hosts for replication or survival, a phenomenon we call 'ready-made' virulence. In the human pathogenic fungus Cryptococcus neoformans, the capacity for virulence in animals may originate from environmental s...

journal_title：Current opinion in microbiology

authors： Casadevall A,Steenbergen JN,Nosanchuk JD

更新日期：2003-08-01 00:00:00

abstract：:Candida albicans is a regular member of the intestinal microbiota in the majority of the human population. This underscores C. albicans' adaptation to life in the intestine without inducing competitive interactions with other microbes, or immune responses detrimental to its survival. However, specific conditions such ...

journal_title：Current opinion in microbiology

authors： Kumamoto CA,Gresnigt MS,Hube B

更新日期：2020-08-01 00:00:00

abstract：:Associations between marine invertebrates and their cooperative bacterial symbionts offer access to an understanding of the roots of host-microbe interaction; for example, several symbioses like the squid-vibrio light organ association serve as models for investigating how each partner affects the developmental biolog...

journal_title：Current opinion in microbiology

authors： McFall-Ngai MJ,Ruby EG

更新日期：2000-12-01 00:00:00

abstract：:Upon infection, both DNA and RNA viruses can be sensed by pattern recognition receptors (PRRs) in the cytoplasm or the nucleus to activate antiviral innate immunity. Sensing of viral products leads to the activation of a signaling cascade that ultimately results in transcriptional activation of type I and III interfer...

journal_title：Current opinion in microbiology

authors： Beachboard DC,Horner SM

更新日期：2016-08-01 00:00:00

abstract：:Kinetoplastea such as trypanosomatid parasites contain specialized peroxisomes that uniquely contain enzymes of the glycolytic pathway and other parts of intermediary metabolism and hence are called glycosomes. Their specific enzyme content can vary strongly, quantitatively and qualitatively, between different species...

journal_title：Current opinion in microbiology

authors： Szöör B,Haanstra JR,Gualdrón-López M,Michels PA

更新日期：2014-12-01 00:00:00

abstract：:In this review, we demonstrate how game theory can be a useful first step in modeling and understanding interactions among bacteria that produce and resist antibiotics. We introduce the basic features of evolutionary game theory and explore model microbial systems that correspond to some classical games. Each game dis...

journal_title：Current opinion in microbiology

authors： Conlin PL,Chandler JR,Kerr B

更新日期：2014-10-01 00:00:00

abstract：:Members of the YidC/Oxa1/Alb3 membrane protein family are multifunctional mediators of membrane protein integration, folding and assembly into large complexes. Their evolutionary conserved and physiologically important role appears to relate to the assembly of major energy-transducing membrane protein complexes. ...

journal_title：Current opinion in microbiology

authors： van der Laan M,Nouwen NP,Driessen AJ

更新日期：2005-04-01 00:00:00

abstract：:Antibiotic lethality is a complex physiological process, sensitive to external cues. Recent advances using systems approaches have revealed how events downstream of primary target inhibition actively participate in antibiotic death processes. In particular, altered metabolism, translational stress and DNA damage each ...

journal_title：Current opinion in microbiology

authors： Yang JH,Bening SC,Collins JJ

更新日期：2017-10-01 00:00:00

abstract：:It is well accepted that bacterial pathogens growing in a biofilm are recalcitrant to the action of most antibiotics and are resistant to the innate immune system. New treatment modalities are greatly warranted to effectively eradicate these infections. However, bacteria growing in a biofilm are metabolically unique i...

journal_title：Current opinion in microbiology

authors： Fey PD

更新日期：2010-10-01 00:00:00

abstract：:In the study of transmembrane transport, molecular phylogeny provides a reliable guide to protein structure, catalytic and noncatalytic transport mechanisms, mode of energy coupling and substrate specificity. It also allows prediction of the evolutionary history of a transporter family, leading to estimations of its a...

journal_title：Current opinion in microbiology

authors： Saier MH

更新日期：1999-10-01 00:00:00

abstract：:Recently, a number of endophytic fungi have been discovered that produce volatile organic compounds (VOCs) whilst growing on agricultural waste substrates, whose chemistry is best defined as hydrocarbon and hydrocarbon-like. These compounds have potential use as both 'green chemicals' and fuels. This report discusses ...

journal_title：Current opinion in microbiology

authors： Strobel G

更新日期：2014-06-01 00:00:00

abstract：:Sexual development in filamentous ascomycetes requires mating-type genes to mediate recognition of compatible cell and nuclear types. Characterization of mating-type genes from various fungi shows that they primarily encode transcriptional regulators. Recent studies on mating-type-specific pheromones and internuclear ...

journal_title：Current opinion in microbiology

authors： Shiu PK,Glass NL

更新日期：2000-04-01 00:00:00

abstract：:The family Arenaviridae consists of a unique genus (Arenavirus) that currently comprises 22 viral species, as recognized by the International Committee for Taxonomy of Viruses. Seven newly discovered represent putative new species. Here, our aims were to provide the most comprehensive phylogenetic analysis of members ...

journal_title：Current opinion in microbiology

authors： Charrel RN,de Lamballerie X,Emonet S

更新日期：2008-08-01 00:00:00

abstract：:Schizosaccharomyces pombe is a useful model system for understanding many aspects of eukaryotic cell growth. Studies of S. pombe have identified novel genes that function in the regulation of iron homeostasis. In response to high levels of iron, Fep1 represses the expression of several genes involved in the acquisitio...

journal_title：Current opinion in microbiology

authors： Labbé S,Khan MG,Jacques JF

更新日期：2013-12-01 00:00:00