Abstract:
:Environmental pathogenic fungi present a paradox in that they are virulent in animals without requiring animal hosts for replication or survival, a phenomenon we call 'ready-made' virulence. In the human pathogenic fungus Cryptococcus neoformans, the capacity for virulence in animals may originate from environmental selective pressures imposed by such organisms as amoeboid and nematode predators. Many C. neoformans virulence factors appear to have 'dual use' capabilities that confer survival advantages in both animal hosts and in the environment. The findings with C. neoformans may provide a paradigm for understanding the origin and maintenance of virulence in other pathogenic environmental fungi.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Casadevall A,Steenbergen JN,Nosanchuk JDdoi
10.1016/s1369-5274(03)00082-1subject
Has Abstractpub_date
2003-08-01 00:00:00pages
332-7issue
4eissn
1369-5274issn
1879-0364pii
S1369527403000821journal_volume
6pub_type
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