The machinery for flavivirus fusion with host cell membranes.

abstract：:The availability of genome information for microbial consortia, including unculturable species, from environmental samples has enabled systems-biology interrogation by providing a means to access genomic, transcriptomic, and proteomic information. This provides a unique opportunity to characterize the molecular activi...

journal_title：Current opinion in microbiology

authors： Hettich RL,Sharma R,Chourey K,Giannone RJ

更新日期：2012-06-01 00:00:00

abstract：:Endosymbiotic theory goes back over 100 years. It explains the similarity of chloroplasts and mitochondria to free-living prokaryotes by suggesting that the organelles arose from prokaryotes through (endo)symbiosis. Gene trees provide important evidence in favour of symbiotic theory at a coarse-grained level, but the ...

journal_title：Current opinion in microbiology

authors： Zimorski V,Ku C,Martin WF,Gould SB

更新日期：2014-12-01 00:00:00

abstract：:Two-thirds of all bacterial genomes sequenced to-date possess an organelle for locomotion, referred to as flagella, periplasmic flagella or type IV pili. These genomes may also contain a chemotaxis-signaling system which governs flagellar rotation, thus leading a coordinated function for motility. Motility and chemota...

journal_title：Current opinion in microbiology

authors： Motaleb MA,Liu J,Wooten RM

更新日期：2015-12-01 00:00:00

abstract：:Helminths parasites undergo developmental changes and migration within their definitive host, in addition to establishing chronic infection. Essential to this is the evasion of host immune responses; the canonical Th2 response is effective at removing parasites resident in the intestine. Conversely, helminths also pro...

journal_title：Current opinion in microbiology

authors： Musah-Eroje M,Flynn RJ

更新日期：2018-12-01 00:00:00

abstract：:Host social interactions can provide multiple complex pathways for microbial transmission. Here, we suggest non-human primates as models to study the social transmission of commensal or mutualistic microbes due to their high sociality, wide range of group compositions and dominance structures, and diverse group intera...

journal_title：Current opinion in microbiology

authors： Kuthyar S,Manus MB,Amato KR

更新日期：2019-08-01 00:00:00

abstract：:Bacterial shape has always been hypothesized to play an important role in the biology of a species and in the ability of certain bacteria to influence human health. The recent discovery of peptidoglycan hydrolases that modulate shape has now allowed this hypothesis to be addressed directly. Genetic, biochemical, and p...

journal_title：Current opinion in microbiology

authors： Frirdich E,Gaynor EC

更新日期：2013-12-01 00:00:00

abstract：:Germ line encoded antiviral defenses in vertebrate cells tend to be either broadly acting factors that exploit general features of viral replication or effectors with strong pathogen preference by virtue of specific recognition of viral proteins. The Mx GTPases, however, are atypical since they have broad antiviral ac...

journal_title：Current opinion in microbiology

authors： Mitchell PS,Emerman M,Malik HS

更新日期：2013-08-01 00:00:00

abstract：:The concept of 'protein function' is rather 'fuzzy' because it is often based on whimsical terms or contradictory nomenclature. This currently presents a challenge for functional genomics because precise definitions are essential for most computational approaches. Addressing this challenge, the notion of networks betw...

journal_title：Current opinion in microbiology

authors： Jansen R,Gerstein M

更新日期：2004-10-01 00:00:00

abstract：:Quorum sensing, or the control of gene expression in response to cell density, is used by both gram-negative and gram-positive bacteria to regulate a variety of physiological functions. In all cases, quorum sensing involves the production and detection of extracellular signalling molecules called autoinducers. While u...

journal_title：Current opinion in microbiology

authors： Bassler BL

更新日期：1999-12-01 00:00:00

abstract：:While natural microbial communities are composed of a mix of microbes with often unknown functions, the construction of synthetic microbial communities allows for the generation of defined systems with reduced complexity. Used in a top-down approach, synthetic communities serve as model systems to ask questions about ...

journal_title：Current opinion in microbiology

authors： Grosskopf T,Soyer OS

更新日期：2014-04-01 00:00:00

abstract：:Sexual development in filamentous ascomycetes requires mating-type genes to mediate recognition of compatible cell and nuclear types. Characterization of mating-type genes from various fungi shows that they primarily encode transcriptional regulators. Recent studies on mating-type-specific pheromones and internuclear ...

journal_title：Current opinion in microbiology

authors： Shiu PK,Glass NL

更新日期：2000-04-01 00:00:00

abstract：:Host-pathogen interactions are often heterogeneous involving individual encounters between host and pathogen cells with diverse molecular mechanisms, response networks, and diverging outcomes. Single-cell reporters can identify the various types of interactions and participating pathogen subsets, help to unravel under...

journal_title：Current opinion in microbiology

authors： Roche B,Bumann D

更新日期：2021-02-01 00:00:00

abstract：:Sensing its changing environment is key for Vibrio cholerae when making the transition from an aquatic lifestyle to one more suited to a human host. An inverse correlation between motility and virulence gene expression has been reported, with the NADH : ubiquinone oxidoreductase system which powers motility by generat...

journal_title：Current opinion in microbiology

authors： Krukonis ES,DiRita VJ

更新日期：2003-04-01 00:00:00

abstract：:Aspergillus fumigatus is an opportunistic fungal pathogen that causes life-threatening infections in immunocompromised individuals. Siderophore-mediated iron acquisition has been shown to be essential for virulence. New studies have revealed that enzymes involved in siderophore biosynthesis and uptake are compartmenta...

journal_title：Current opinion in microbiology

authors： Moore MM

更新日期：2013-12-01 00:00:00

abstract：:The RNA chaperone protein Hfq is critical to the function of small, base pairing RNAs in many bacteria. In the past few years, structures and modeling of wild type Hfq and assays of various mutants have documented that the homohexameric Hfq ring can contact RNA at four sites (proximal face, distal face, rim and C-term...

journal_title：Current opinion in microbiology

authors： Updegrove TB,Zhang A,Storz G

更新日期：2016-04-01 00:00:00

abstract：:Inducible tolerance to acidic and alkaline environments is recognized as an important survival strategy for many prokaryotic and eukaryotic microorganisms. Recent developments in understanding this phenomenon include the identification of regulatory genes, specific tolerance mechanisms and genes associated with tolera...

journal_title：Current opinion in microbiology

authors： Foster JW

更新日期：1999-04-01 00:00:00

abstract：:The protozoan parasite Trypanosoma brucei is the causative agent of African sleeping sickness and the wasting disease, nagana, in cattle. The parasite is transmitted to the mammalian host by the bite of a tsetse fly. These parasites lack transcriptional regulation, and their gene expression is mainly regulated post-tr...

journal_title：Current opinion in microbiology

authors： Michaeli S

更新日期：2014-08-01 00:00:00

abstract：:The quest for the discovery of novel natural products has entered a new chapter with the enormous wealth of genetic data that is now available. This information has been exploited by using whole-genome sequence mining to uncover cryptic pathways, or biosynthetic pathways for previously undetected metabolites. Alternat...

journal_title：Current opinion in microbiology

authors： Van Lanen SG,Shen B

更新日期：2006-06-01 00:00:00

abstract：:Bacteria furnish tractable models for complex biological processes, and morphogenesis is now taking its turn. We can already explain in general terms how such elementary forms as rods and cocci are produced, and the shapes of several individual organisms are coming into focus. In most bacteria shape is maintained by t...

journal_title：Current opinion in microbiology

authors： Harold FM

更新日期：2007-12-01 00:00:00

abstract：:Trypanosomes and Leishmania contain an abundance of stage-regulated cysteine proteinases encoded by several gene families. Analysis of parasites rendered defective in cysteine proteinase function, either through genetic manipulation or through the use of specific inhibitors, has revealed roles for the enzymes in paras...

journal_title：Current opinion in microbiology

authors： Mottram JC,Brooks DR,Coombs GH

更新日期：1998-08-01 00:00:00

abstract：:Membrane shape is functionally linked with many cellular processes. The limiting membrane of vacuoles containing Toxoplasma gondii and Plasmodium apicomplexan parasites lies at the host-parasite interface. This membrane comprises intra-vacuolar and extra-vacuolar tubulo-vesicular deformations, which influence host-par...

journal_title：Current opinion in microbiology

authors： Santi-Rocca J,Blanchard N

更新日期：2017-12-01 00:00:00

abstract：:Proteomic studies are designed to yield either qualitative information on proteins (identification, distribution, posttranslational modifications, interactions, structure and function) or quantitative information (abundance, distribution within different localizations, temporal changes in abundance due to synthesis an...

journal_title：Current opinion in microbiology

authors： Otto A,Bernhardt J,Hecker M,Becher D

更新日期：2012-06-01 00:00:00

abstract：:Major advances have been made in the past five years in the identification of cellular targets of toxins produced by anaerobic bacteria. These targets include the vesicular membrane docking and fusion apparatus, the actin cytoskeleton, the signal transduction machinery and the cell membrane. The recent discovery that ...

journal_title：Current opinion in microbiology

authors： Boquet P,Munro P,Fiorentini C,Just I

更新日期：1998-02-01 00:00:00

abstract：:Antibiotic lethality is a complex physiological process, sensitive to external cues. Recent advances using systems approaches have revealed how events downstream of primary target inhibition actively participate in antibiotic death processes. In particular, altered metabolism, translational stress and DNA damage each ...

journal_title：Current opinion in microbiology

authors： Yang JH,Bening SC,Collins JJ

更新日期：2017-10-01 00:00:00

abstract：:The Saccharomyces cerevisiae genome sequence, augmented by new data on gene expression and function, continues to yield new findings about eukaryote genome evolution. Analysis of the duplicate gene pairs formed by whole-genome duplication indicates that selection for increased levels of gene expression was a significa...

journal_title：Current opinion in microbiology

authors： Seoighe C,Wolfe KH

更新日期：1999-10-01 00:00:00

abstract：:Wild Escherichia coli are superbly adapted to survive in the intestines of their mammalian hosts and in the environment. E. coli K12 derivative (MG1655) encodes 4288 potential genes that provide the background genetic framework of this species. Particular E. coli clonal types encode additional chromosomal and extrachr...

journal_title：Current opinion in microbiology

authors： Dougan G,Haque A,Pickard D,Frankel G,O'Goara P,Wain J

更新日期：2001-02-01 00:00:00

abstract：:The acquisition of drug resistance by Plasmodium falciparum has severely curtailed global efforts to control malaria. Our ability to define resistance has been greatly enhanced by recent advances in Plasmodium genetics and genomics. Sequencing and microarray studies have identified thousands of polymorphisms in the P....

journal_title：Current opinion in microbiology

authors： Ekland EH,Fidock DA

更新日期：2007-08-01 00:00:00

abstract：:Analyses of the complex regulatory networks leading to T cell survival, death, and immune deficiency have been aided in the past year by the dramatic development of new technologies to identify T cells and assess T cell function. These new techniques have shown that functional inactivation and apoptotic elimination of...

journal_title：Current opinion in microbiology

authors： Welsh RM,McNally JM

更新日期：1999-08-01 00:00:00

abstract：:One current challenge in metabolic systems biology is to map out the regulation networks that control metabolism. From progress in this area, we conclude that non-transcriptional mechanisms (e.g. metabolite-protein interactions and protein phosphorylation) are highly relevant in actually controlling metabolic function...

journal_title：Current opinion in microbiology

authors： Heinemann M,Sauer U

更新日期：2010-06-01 00:00:00

abstract：:Intracellular bacteria in mammalian host cells can either live in a membrane-bound vacuole modified to support bacterial growth, or escape from the primary phagosome into the host cell cytoplasm. Phagosomal escape is best studied in Listeria monocytogenes in which a pore-forming cytolysin and two phospholipases are in...

journal_title：Current opinion in microbiology

authors： Goebel W,Kuhn M

更新日期：2000-02-01 00:00:00