Abstract:
:Candida albicans is a regular member of the intestinal microbiota in the majority of the human population. This underscores C. albicans' adaptation to life in the intestine without inducing competitive interactions with other microbes, or immune responses detrimental to its survival. However, specific conditions such as a dysbalanced microbiome, a suppression of the immune system, and an impaired intestinal barrier can predispose for invasive, mostly nosocomial, C. albicans infections. Colonization of the intestine and translocation through the intestinal barrier are fundamental aspects of the processes preceding life-threatening systemic candidiasis. Insights into C. albicans' commensal lifestyle and translocation can thus help us to understand how patients develop candidiasis, and may provide leads for therapeutic strategies aimed at preventing infection. In this review, we discuss the commensal lifestyle of C. albicans in the intestine, the role of morphology for commensalism, the influence of diet, and the interactions with bacteria of the microbiota.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Kumamoto CA,Gresnigt MS,Hube Bdoi
10.1016/j.mib.2020.05.006subject
Has Abstractpub_date
2020-08-01 00:00:00pages
7-15eissn
1369-5274issn
1879-0364pii
S1369-5274(20)30066-7journal_volume
56pub_type
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