Human cytomegalovirus persistence and latency in endothelial cells and macrophages.

abstract：:One defining feature of apicomplexan parasites is their special ability to actively invade host cells. Although rapid, invasion is a complicated process that requires coordinated activities of host cell attachment, protein secretion, and motility by the parasite. Central to this process is the establishment of a struc...

journal_title：Current opinion in microbiology

authors： Shen B,Sibley LD

更新日期：2012-08-01 00:00:00

abstract：:Activation of professional phagocytes with the concomitant generation of oxidant species is a medullar innate immune process for the control of acute Trypanosoma cruzi infection. Recent data reinforce the hypothesis that parasites more prepared to deal with the host-oxidative assault are more efficient for the establi...

journal_title：Current opinion in microbiology

authors： Piacenza L,Alvarez MN,Peluffo G,Radi R

更新日期：2009-08-01 00:00:00

abstract：:High-throughput identification of proteins and their accurate partial sequencing by shotgun nanoLC-MS/MS are now feasible for any cellular model at a full genomic scale. Proteogenomics is the integration of these data with the genome. Mining microbial proteomes allows validation of predicted orphan genes and correctio...

journal_title：Current opinion in microbiology

authors： Armengaud J

更新日期：2009-06-01 00:00:00

abstract：:Huge numbers of enzymes have evolved in nature to function in aqueous environments at moderate temperatures and neutral pH. This gives us, in principle, the unique opportunity to construct multistep reaction systems of considerable catalytic complexity in vitro. However, this opportunity is rarely exploited beyond res...

journal_title：Current opinion in microbiology

authors： Meyer A,Pellaux R,Panke S

更新日期：2007-06-01 00:00:00

abstract：:Recent developments have increased our understanding of the evolution of mutualistic associations between Epichloë endophytes and their grass hosts. Most of the asexual species appear to be interspecific hybrids. Although endophytes form compatible associations with their natural hosts, transfers to other hosts elicit...

journal_title：Current opinion in microbiology

authors： Scott B

更新日期：2001-08-01 00:00:00

abstract：:The ongoing development of metagenomic approaches is providing the means to explore antibiotic resistance in nature and address questions that could not be answered previously with conventional culture-based strategies. The number of available environmental metagenomic sequence datasets is rapidly expanding and hencef...

journal_title：Current opinion in microbiology

authors： Monier JM,Demanèche S,Delmont TO,Mathieu A,Vogel TM,Simonet P

更新日期：2011-06-01 00:00:00

abstract：:Several species of Archaea are involved in symbiotic or parasitic associations with representatives of Eukarya, Bacteria and other Archaea. Eukaryal interactions include different members of methanogens, found in the gut of arthropods, in the rumen of cattle, and in the human intestine, while Cenarchaeum symbiosum is ...

journal_title：Current opinion in microbiology

authors： Moissl-Eichinger C,Huber H

更新日期：2011-06-01 00:00:00

abstract：:Bacterial two-component systems (TCSs) and small regulatory RNAs (sRNAs) form densely interconnected networks that integrate and transduce information from the environment into fine-tuned changes of gene expression. Many TCSs control target genes indirectly through regulation of sRNAs, which in turn regulate gene expr...

journal_title：Current opinion in microbiology

authors： Göpel Y,Görke B

更新日期：2012-04-01 00:00:00

abstract：:Systems biology is a rapidly expanding field fuelled by the 'omics' era coupled to several new technological advances that have increased the precision of data obtainable, meaning that it is now feasible to obtain quantitative measurements from a single cell. The aim of systems biology is to understand the structure, ...

journal_title：Current opinion in microbiology

authors： Kay E,Wren BW

更新日期：2009-10-01 00:00:00

abstract：:In response to starvation, myxobacteria build multicellular fruiting bodies that contain many thousands of cells and that have particular species-specific shapes. To coordinate fruiting body development, the myxobacterial cells signal to each other. The timing of and cellular responses to these signals help to give fo...

journal_title：Current opinion in microbiology

authors： Kaiser D

更新日期：1998-12-01 00:00:00

abstract：:The opportunistic fungal pathogen Aspergillus fumigatus adapts to iron limitation by upregulation of iron uptake mechanisms including siderophore biosynthesis and downregulation of iron-consuming pathways to spare iron. These metabolic changes depend mainly on the transcription factor HapX. Consistent with the crucial...

journal_title：Current opinion in microbiology

authors： Schrettl M,Haas H

更新日期：2011-08-01 00:00:00

abstract：:Environmental pathogenic fungi present a paradox in that they are virulent in animals without requiring animal hosts for replication or survival, a phenomenon we call 'ready-made' virulence. In the human pathogenic fungus Cryptococcus neoformans, the capacity for virulence in animals may originate from environmental s...

journal_title：Current opinion in microbiology

authors： Casadevall A,Steenbergen JN,Nosanchuk JD

更新日期：2003-08-01 00:00:00

abstract：:The environment is suffused with nearly countless types of fungi, and our immune systems must be tuned to cope with constant exposure to them. In addition, it is becoming increasingly clear that many surfaces of our bodies are colonized with complex populations of fungi (the mycobiome) in the same way that they are co...

journal_title：Current opinion in microbiology

authors： Iliev ID,Underhill DM

更新日期：2013-06-01 00:00:00

abstract：:The protozoan parasite Trypanosoma brucei is the causative agent of African sleeping sickness and the wasting disease, nagana, in cattle. The parasite is transmitted to the mammalian host by the bite of a tsetse fly. These parasites lack transcriptional regulation, and their gene expression is mainly regulated post-tr...

journal_title：Current opinion in microbiology

authors： Michaeli S

更新日期：2014-08-01 00:00:00

abstract：:Eukaryotes host numerous intracellular and associated microbes in their microbiota. Fungi, the so-called Mycobiota, are important members of both human and plant microbiota. Moreover, members of the plant mycobiota host their own microbiota on their surfaces and inside their hyphae. The microbiota of the mycobiota inc...

journal_title：Current opinion in microbiology

authors： Bonfante P,Venice F,Lanfranco L

更新日期：2019-06-01 00:00:00

abstract：:Proteomic studies are designed to yield either qualitative information on proteins (identification, distribution, posttranslational modifications, interactions, structure and function) or quantitative information (abundance, distribution within different localizations, temporal changes in abundance due to synthesis an...

journal_title：Current opinion in microbiology

authors： Otto A,Bernhardt J,Hecker M,Becher D

更新日期：2012-06-01 00:00:00

abstract：:Helminths parasites undergo developmental changes and migration within their definitive host, in addition to establishing chronic infection. Essential to this is the evasion of host immune responses; the canonical Th2 response is effective at removing parasites resident in the intestine. Conversely, helminths also pro...

journal_title：Current opinion in microbiology

authors： Musah-Eroje M,Flynn RJ

更新日期：2018-12-01 00:00:00

abstract：:Recently developed techniques allow genomic DNA sequencing from single microbial cells [Lasken RS: Single-cell genomic sequencing using multiple displacement amplification. Curr Opin Microbiol 2007, 10:510-516]. Here, we focus on research strategies for putting these methods into practice in the laboratory setting. An...

journal_title：Current opinion in microbiology

authors： Ishoey T,Woyke T,Stepanauskas R,Novotny M,Lasken RS

更新日期：2008-06-01 00:00:00

abstract：:Biofilm development and quorum sensing (QS) are closely interconnected processes. Biofilm formation is a cooperative group behaviour that involves bacterial populations living embedded in a self-produced extracellular matrix. QS is a cell-cell communication mechanism that synchronizes gene expression in response to po...

journal_title：Current opinion in microbiology

authors： Solano C,Echeverz M,Lasa I

更新日期：2014-04-01 00:00:00

abstract：:Most Candida albicans strains are heterozygous at the MTL (mating-type-like) locus, but mating occurs in hemi- or homozygous strains. The white-opaque switch process is repressed by the heterodimer of the MTLa1 and MTLalpha2 gene products, while mating genes are induced by a2 and alpha1. Mating occurs in opaque cells ...

journal_title：Current opinion in microbiology

authors： Magee PT,Magee BB

更新日期：2004-12-01 00:00:00

abstract：:Pyrrolysine is an amino acid encoded by the amber codon in genes required for methylamine utilization by members of the Methanosarcinaceae. Pyrrolysine and selenocysteine share the distinction of being the only two non-canonical amino acids that have entered natural genetic codes. Recent experiments have shown that en...

journal_title：Current opinion in microbiology

authors： Krzycki JA

更新日期：2005-12-01 00:00:00

abstract：:Recent work on cell division and chromosome orientation and partitioning in Bacillus subtilis has provided insights into cell cycle regulation during growth and development. The cell cycle is an integral part of development and entrance into sporulation is modulated by signals that transmit the status of DNA integrity...

journal_title：Current opinion in microbiology

authors： Levin PA,Grossman AD

更新日期：1998-12-01 00:00:00

abstract：:The 21st century has seen the licensure of new anti-infective vaccines that have demonstrated their benefit for both individual and population (herd) protection. Despite this there are still many human pathogens for which no vaccine is available. As we learn more about these pathogens, and as technologies advance, mor...

journal_title：Current opinion in microbiology

authors： Scully IL,Swanson K,Green L,Jansen KU,Anderson AS

更新日期：2015-10-01 00:00:00

abstract：:One promise of synthetic biology is to provide solutions for biomedical and industrial problems by rational design of added functionality in living systems. Microbes are at the forefront of this biological engineering endeavor due to their general ease of handling and their relevance in many potential applications fro...

journal_title：Current opinion in microbiology

authors： Bittihn P,Din MO,Tsimring LS,Hasty J

更新日期：2018-10-01 00:00:00

abstract：:The central role of small RNAs in regulating bacterial gene expression has been elucidated in the past years. Typically, small RNAs act via specific basepairing with target mRNAs, leading to modulation of translation initiation and mRNA stability. Quantitative studies suggest that small RNA regulation is characterized...

journal_title：Current opinion in microbiology

authors： Levine E,Hwa T

更新日期：2008-12-01 00:00:00

abstract：:Most studies of small regulatory RNAs in bacteria have focussed on conserved transcripts in intergenic regions. However, several recent developments including single-nucleotide resolution transcriptome profiling by RNA-seq and increased knowledge of the cellular targets of the RNA chaperone Hfq suggest that the bacter...

journal_title：Current opinion in microbiology

authors： Miyakoshi M,Chao Y,Vogel J

更新日期：2015-04-01 00:00:00

abstract：:Upon infection, both DNA and RNA viruses can be sensed by pattern recognition receptors (PRRs) in the cytoplasm or the nucleus to activate antiviral innate immunity. Sensing of viral products leads to the activation of a signaling cascade that ultimately results in transcriptional activation of type I and III interfer...

journal_title：Current opinion in microbiology

authors： Beachboard DC,Horner SM

更新日期：2016-08-01 00:00:00

abstract：:Recent studies on antibacterials have focused on the development of antimycobacterial agents and antibacterial peptides, and on furthering the understanding of agents that have been available for several decades, including imidazoles, beta-lactams and quinolones. New areas of research include antisense oligonucleotide...

journal_title：Current opinion in microbiology

authors： Piddock LJ

更新日期：1998-10-01 00:00:00

abstract：:The obligatory intracellular bacterial pathogens Anaplasma and Ehrlichia infect leukocytes by hijacking host-cell components and processes. The type IV secretion system is up-regulated during infection. Among type IV secretion candidate substrates, an ankyrin repeat protein of Anaplasma phagocytophilum, AnkA, is deliv...

journal_title：Current opinion in microbiology

authors： Rikihisa Y,Lin M

更新日期：2010-02-01 00:00:00

abstract：:Integrative and conjugative elements (ICEs) are nearly ubiquitous in microbial genomes and influence their evolution by providing adaptive functions to their host and by enhancing genome plasticity and diversification. For a long-time, it has been assumed that by integrating into the chromosome of their host, these se...

journal_title：Current opinion in microbiology

authors： Burrus V

更新日期：2017-08-01 00:00:00