Abstract:
:The obligatory intracellular bacterial pathogens Anaplasma and Ehrlichia infect leukocytes by hijacking host-cell components and processes. The type IV secretion system is up-regulated during infection. Among type IV secretion candidate substrates, an ankyrin repeat protein of Anaplasma phagocytophilum, AnkA, is delivered into the host cytoplasm via a complex that includes VirD4. AnkA is highly tyrosine phosphorylated and binds to the Abl interactor 1, SHP-1, and nuclear DNA fragments. Ehrlichia chaffeensis AnkA was recently reported to be translocated into host-cell nucleus. The recent discovery of several ankyrin repeat proteins secreted via the type IV secretion system of different intracellular bacteria suggests that a common strategy evolved to subvert host-cell functions.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Rikihisa Y,Lin Mdoi
10.1016/j.mib.2009.12.008subject
Has Abstractpub_date
2010-02-01 00:00:00pages
59-66issue
1eissn
1369-5274issn
1879-0364pii
S1369-5274(09)00187-8journal_volume
13pub_type
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