Anaplasma phagocytophilum and Ehrlichia chaffeensis type IV secretion and Ank proteins.

Abstract:

:The obligatory intracellular bacterial pathogens Anaplasma and Ehrlichia infect leukocytes by hijacking host-cell components and processes. The type IV secretion system is up-regulated during infection. Among type IV secretion candidate substrates, an ankyrin repeat protein of Anaplasma phagocytophilum, AnkA, is delivered into the host cytoplasm via a complex that includes VirD4. AnkA is highly tyrosine phosphorylated and binds to the Abl interactor 1, SHP-1, and nuclear DNA fragments. Ehrlichia chaffeensis AnkA was recently reported to be translocated into host-cell nucleus. The recent discovery of several ankyrin repeat proteins secreted via the type IV secretion system of different intracellular bacteria suggests that a common strategy evolved to subvert host-cell functions.

journal_name

Curr Opin Microbiol

authors

Rikihisa Y,Lin M

doi

10.1016/j.mib.2009.12.008

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

59-66

issue

1

eissn

1369-5274

issn

1879-0364

pii

S1369-5274(09)00187-8

journal_volume

13

pub_type

杂志文章,评审
  • Iron uptake and regulation in Schizosaccharomyces pombe.

    abstract::Schizosaccharomyces pombe is a useful model system for understanding many aspects of eukaryotic cell growth. Studies of S. pombe have identified novel genes that function in the regulation of iron homeostasis. In response to high levels of iron, Fep1 represses the expression of several genes involved in the acquisitio...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2013.07.007

    authors: Labbé S,Khan MG,Jacques JF

    更新日期:2013-12-01 00:00:00

  • Using laser tweezers to measure twitching motility in Neisseria.

    abstract::Dynamic properties of type IV pili are essential for their function in bacterial infection, twitching motility and gene transfer. Laser tweezers are versatile tools to study the molecular mechanism underlying pilus dynamics at the single molecule level. Recently, these optical tweezers have been used to monitor pilus ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2005.04.002

    authors: Maier B

    更新日期:2005-06-01 00:00:00

  • Metal-homeostasis in the pathobiology of the opportunistic human fungal pathogen Aspergillus fumigatus.

    abstract::In contrast to obligate pathogens opportunistic pathogens such as Aspergillus fumigatus do not need a specific host to propagate or survive. However several characteristics of the saprophytic life-style and the selective pressure encountered in the primary ecological niche contribute to the virulence of A. fumigatus. ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2017.11.015

    authors: Blatzer M,Latgé JP

    更新日期:2017-12-01 00:00:00

  • Sustained sensing as an emerging principle in second messenger signaling systems.

    abstract::Bacteria utilize a diverse set of nucleotide second messengers to regulate cellular responses by binding macromolecular receptors (RNAs and proteins). Recent studies on cyclic di-GMP (c-di-GMP) have shown that this signaling molecule binds multiple receptors to regulate different steps in the same biological process. ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2016.08.010

    authors: Orr MW,Galperin MY,Lee VT

    更新日期:2016-12-01 00:00:00

  • Microbial community proteomics: elucidating the catalysts and metabolic mechanisms that drive the Earth's biogeochemical cycles.

    abstract::Molecular techniques are providing unprecedented insights into the organismal and functional make-up of natural microbial consortia. Apart from nucleic acid based approaches, community proteomics has the potential to provide a high-resolution representation of genotypic and phenotypic traits of distinct community memb...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2009.03.004

    authors: Wilmes P,Bond PL

    更新日期:2009-06-01 00:00:00

  • 6S RNA: a small RNA regulator of transcription.

    abstract::Appreciation for the prevalence and diversity of noncoding, small RNAs (sRNAs) has grown enormously in the past decade. A major role for sRNAs in all organisms is to regulate gene expression, often at the level of mRNA translation or stability. However, a few sRNAs have been shown to function by regulating transcripti...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2007.03.008

    authors: Wassarman KM

    更新日期:2007-04-01 00:00:00

  • From motility to virulence: Sensing and responding to environmental signals in Vibrio cholerae.

    abstract::Sensing its changing environment is key for Vibrio cholerae when making the transition from an aquatic lifestyle to one more suited to a human host. An inverse correlation between motility and virulence gene expression has been reported, with the NADH : ubiquinone oxidoreductase system which powers motility by generat...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/s1369-5274(03)00032-8

    authors: Krukonis ES,DiRita VJ

    更新日期:2003-04-01 00:00:00

  • Controlling mRNA stability and translation with small, noncoding RNAs.

    abstract::Recent studies have led to the identification of more than 50 small regulatory RNAs in Escherichia coli. Only a subset of these RNAs has been characterized. However, it is clear that many of the RNAs, such as the MicF, OxyS, DsrA, Spot42 and RyhB RNAs, act by basepairing to activate or repress translation or to destab...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2004.02.015

    authors: Storz G,Opdyke JA,Zhang A

    更新日期:2004-04-01 00:00:00

  • Bacterial communities in industrial wastewater bioreactors.

    abstract::Wastewater bioreactors have been used to treat domestic and industrial waste for nearly a century. Development of molecular tools such as PCR and DNA microarrays have enabled identification and characterization of some of the microbes in these bioreactors; however, molecular characterization of the microbes is still i...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2006.04.005

    authors: Bramucci M,Nagarajan V

    更新日期:2006-06-01 00:00:00

  • How bacteria talk to each other: regulation of gene expression by quorum sensing.

    abstract::Quorum sensing, or the control of gene expression in response to cell density, is used by both gram-negative and gram-positive bacteria to regulate a variety of physiological functions. In all cases, quorum sensing involves the production and detection of extracellular signalling molecules called autoinducers. While u...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/s1369-5274(99)00025-9

    authors: Bassler BL

    更新日期:1999-12-01 00:00:00

  • Genomics and computational molecular biology.

    abstract::There has been a dramatic increase in the number of completely sequenced bacterial genomes during the past two years as a result of the efforts both of public genome agencies and the pharmaceutical industry. The availability of completely sequenced genomes permits more systematic analyses of genes, evolution and genom...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/s1369-5274(98)80039-8

    authors: Brutlag DL

    更新日期:1998-06-01 00:00:00

  • Bacteriophage endolysins--current state of research and applications.

    abstract::Endolysins are phage-encoded enzymes that break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. Their action is tightly regulated by holins, by membrane arrest, and by conversion from their inactive to active state. Recent research has not only revealed the unexpected diversity of t...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2005.06.002

    authors: Loessner MJ

    更新日期:2005-08-01 00:00:00

  • Recent advances in systems microbiology.

    abstract::Systems biology is a rapidly expanding field fuelled by the 'omics' era coupled to several new technological advances that have increased the precision of data obtainable, meaning that it is now feasible to obtain quantitative measurements from a single cell. The aim of systems biology is to understand the structure, ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2009.08.007

    authors: Kay E,Wren BW

    更新日期:2009-10-01 00:00:00

  • The clinical consequences of antimicrobial resistance.

    abstract::The continued evolution of antimicrobial resistance in the hospital and more recently in the community threatens to seriously compromise our ability to treat serious infections. The major success of the seven-valent Streptococcus pneumoniae vaccine at reducing both infection and resistance has been followed by the eme...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2009.08.001

    authors: Rice LB

    更新日期:2009-10-01 00:00:00

  • Fecal transplants as a microbiome-based therapeutic.

    abstract::Impaired microbiome diversity and composition can develop into a potent etiological agent of disease and increase susceptibility to infection. Given this, interventions targeting the microbiome have developed rapidly, with healthy donor feces being a de facto source of beneficial communities employed to rebalance pati...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2020.05.008

    authors: Kaakoush NO

    更新日期:2020-08-01 00:00:00

  • Auxiliary phosphatases in two-component signal transduction.

    abstract::Signal termination in two-component systems occurs by loss of the phosphoryl group from the response regulator protein. This review explores our current understanding of the structures, catalytic mechanisms and means of regulation of the known families of phosphatases that catalyze response regulator dephosphorylation...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2010.01.004

    authors: Silversmith RE

    更新日期:2010-04-01 00:00:00

  • What's in the mix: phylogenetic classification of metagenome sequence samples.

    abstract::Metagenomics is a novel field which deals with the sequencing and study of microbial organisms or viruses isolated directly from a particular environment. This has already provided a wealth of information and new insights for the inhabitants of various environmental niches. For a given sample, one would like to determ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2007.08.004

    authors: McHardy AC,Rigoutsos I

    更新日期:2007-10-01 00:00:00

  • Single-cell genomic sequencing using Multiple Displacement Amplification.

    abstract::Single microbial cells can now be sequenced using DNA amplified by the Multiple Displacement Amplification (MDA) reaction. The few femtograms of DNA in a bacterium are amplified into micrograms of high molecular weight DNA suitable for DNA library construction and Sanger sequencing. The MDA-generated DNA also performs...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2007.08.005

    authors: Lasken RS

    更新日期:2007-10-01 00:00:00

  • Epigenetic regulation of the bacterial cell cycle.

    abstract::N(6)-methyl-adenines can serve as epigenetic signals for interactions between regulatory DNA sequences and regulatory proteins that control cellular functions, such as the initiation of chromosome replication or the expression of specific genes. Several of these genes encode master regulators of the bacterial cell cyc...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2009.08.005

    authors: Collier J

    更新日期:2009-12-01 00:00:00

  • Silencing of foreign DNA in bacteria.

    abstract::Xenogeneic silencing proteins facilitate horizontal gene transfer by silencing expression of AT-rich sequences. By virtue of their activity these proteins serve as master regulators of a variety of important functions including motility, drug resistance, and virulence. Three families of silencers have been identified ...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2011.12.014

    authors: Ali SS,Xia B,Liu J,Navarre WW

    更新日期:2012-04-01 00:00:00

  • Iron homeostasis--Achilles' heel of Aspergillus fumigatus?

    abstract::The opportunistic fungal pathogen Aspergillus fumigatus adapts to iron limitation by upregulation of iron uptake mechanisms including siderophore biosynthesis and downregulation of iron-consuming pathways to spare iron. These metabolic changes depend mainly on the transcription factor HapX. Consistent with the crucial...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2011.06.002

    authors: Schrettl M,Haas H

    更新日期:2011-08-01 00:00:00

  • The role of Dectin-1 in the host defence against fungal infections.

    abstract::Dectin-1 is an innate immune pattern recognition receptor (PRR) that, through its ability to bind β-glucans, is involved in the recognition of several pathogenic fungi. Dectin-1 can stimulate a variety of cellular responses via the Syk/CARD9 signalling pathway, including phagocytosis, cytokine production and the respi...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2011.07.001

    authors: Drummond RA,Brown GD

    更新日期:2011-08-01 00:00:00

  • Emerging views on integrin signaling via Rac1 during invasin-promoted bacterial uptake.

    abstract::Enteropathogenic Yersinia species encode invasin, which promotes uptake into host cells by binding beta1 integrins. Invasin may cluster integrin heterodimers extracellularly and cause the integrin alpha and beta chains to splay apart in the cytoplasm. Cdc42 signaling is not essential for Yersinia uptake, whereas invas...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2004.12.009

    authors: Wong KW,Isberg RR

    更新日期:2005-02-01 00:00:00

  • Transitions and transmission: behavior and physiology as drivers of honey bee-associated microbial communities.

    abstract::Microbial communities have considerable impacts on animal health. However, only in recent years have the host factors impacting microbiome composition been explored. An increasing wealth of microbiome data in combination with decades of research on behavior, physiology, and development have resulted in the European ho...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2019.08.001

    authors: Miller DL,Parish AJ,Newton IL

    更新日期:2019-08-01 00:00:00

  • When protons attack: microbial strategies of acid adaptation.

    abstract::Inducible tolerance to acidic and alkaline environments is recognized as an important survival strategy for many prokaryotic and eukaryotic microorganisms. Recent developments in understanding this phenomenon include the identification of regulatory genes, specific tolerance mechanisms and genes associated with tolera...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/S1369-5274(99)80030-7

    authors: Foster JW

    更新日期:1999-04-01 00:00:00

  • The coming of age of niche vaccines? Effect of vaccines on resistance profiles in Streptococcus pneumoniae.

    abstract::Pneumococcal conjugate vaccine is not only effective against invasive and non-invasive disease in all ages but also has a significant impact on antibiotic-resistant infections since a number of resistant serotypes are targeted by the vaccine. Surveillance studies in the post-licensure years have shown an increase in n...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2007.08.008

    authors: McGee L

    更新日期:2007-10-01 00:00:00

  • Cytoskeleton and motor proteins in filamentous fungi.

    abstract::In filamentous fungi, the actin cytoskeleton is required for polarity establishment and maintenance at hyphal tips and for formation of a contractile ring at sites of septation. Recently, formins have been identified as Arp (actin-related protein) 2/3-independent nucleators of actin polymerization, and filamentous fun...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2003.10.009

    authors: Xiang X,Plamann M

    更新日期:2003-12-01 00:00:00

  • Coxiella type IV secretion and cellular microbiology.

    abstract::Coxiella burnetii is a widespread zoonotic bacterial pathogen that causes human Q fever. In vivo, Coxiella displays a tropism for mononuclear phagocytes where it participates in biogenesis of a lysosome-like replication compartment to conduct its obligate intracellular lifestyle. Coxiella actively regulates multiple e...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2008.11.005

    authors: Voth DE,Heinzen RA

    更新日期:2009-02-01 00:00:00

  • Genome archeology leading to the characterization and classification of transport proteins.

    abstract::In the study of transmembrane transport, molecular phylogeny provides a reliable guide to protein structure, catalytic and noncatalytic transport mechanisms, mode of energy coupling and substrate specificity. It also allows prediction of the evolutionary history of a transporter family, leading to estimations of its a...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章

    doi:10.1016/s1369-5274(99)00016-8

    authors: Saier MH

    更新日期:1999-10-01 00:00:00

  • Type III secretion systems shape up as they ship out.

    abstract::Virulence associated protein type III secretion systems (T3SSs) are intricately structured organic nanosyringes that achieve the translocation of bacterial proteins from the prokaryotic cytoplasm across three membranes into the host cytosol. The substrates for these systems number in the hundreds, with remarkably dive...

    journal_title:Current opinion in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.mib.2009.11.001

    authors: Marlovits TC,Stebbins CE

    更新日期:2010-02-01 00:00:00