Metagenomic exploration of antibiotic resistance in soil.

Abstract:

:The ongoing development of metagenomic approaches is providing the means to explore antibiotic resistance in nature and address questions that could not be answered previously with conventional culture-based strategies. The number of available environmental metagenomic sequence datasets is rapidly expanding and henceforth offer the ability to gain a more comprehensive understanding of antibiotic resistance at the global scale. Although there is now evidence that the environment constitutes a vast reservoir of antibiotic resistance gene determinants (ARGDs) and that the majority of ARGDs acquired by human pathogens may have an environmental origin, a better understanding of their diversity, prevalence and ecological significance may help predict the emergence and spreading of newly acquired resistances. Recent applications of metagenomic approaches to the study of ARGDs in natural environments such as soil should help overcome challenges concerning expanding antibiotic resistances.

journal_name

Curr Opin Microbiol

authors

Monier JM,Demanèche S,Delmont TO,Mathieu A,Vogel TM,Simonet P

doi

10.1016/j.mib.2011.04.010

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

229-35

issue

3

eissn

1369-5274

issn

1879-0364

pii

S1369-5274(11)00058-0

journal_volume

14

pub_type

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