Abstract:
:The ongoing development of metagenomic approaches is providing the means to explore antibiotic resistance in nature and address questions that could not be answered previously with conventional culture-based strategies. The number of available environmental metagenomic sequence datasets is rapidly expanding and henceforth offer the ability to gain a more comprehensive understanding of antibiotic resistance at the global scale. Although there is now evidence that the environment constitutes a vast reservoir of antibiotic resistance gene determinants (ARGDs) and that the majority of ARGDs acquired by human pathogens may have an environmental origin, a better understanding of their diversity, prevalence and ecological significance may help predict the emergence and spreading of newly acquired resistances. Recent applications of metagenomic approaches to the study of ARGDs in natural environments such as soil should help overcome challenges concerning expanding antibiotic resistances.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Monier JM,Demanèche S,Delmont TO,Mathieu A,Vogel TM,Simonet Pdoi
10.1016/j.mib.2011.04.010subject
Has Abstractpub_date
2011-06-01 00:00:00pages
229-35issue
3eissn
1369-5274issn
1879-0364pii
S1369-5274(11)00058-0journal_volume
14pub_type
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