Gene expression in Kinetoplastids.

abstract：:In response to starvation, myxobacteria build multicellular fruiting bodies that contain many thousands of cells and that have particular species-specific shapes. To coordinate fruiting body development, the myxobacterial cells signal to each other. The timing of and cellular responses to these signals help to give fo...

journal_title：Current opinion in microbiology

authors： Kaiser D

更新日期：1998-12-01 00:00:00

abstract：:In the process of yeast budding, an aged and deteriorated mother cell gives rise to a youthful and pristine daughter cell. This remarkable event offers a tractable model system for identifying factors affecting life expectancy and it has been established that multiple aging factors operate in parallel. Herein, we will...

journal_title：Current opinion in microbiology

authors： Nyström T,Liu B

更新日期：2014-04-01 00:00:00

abstract：:Natural prokaryotic populations are composed of multiple clonal lineages that are different in their core genomes in a range that varies typically between 95 and 100% nucleotide identity. Each clonal lineage also carries a complement of not shared flexible genes that can be very large. The compounded flexible genome p...

journal_title：Current opinion in microbiology

authors： Rodriguez-Valera F,Martin-Cuadrado AB,López-Pérez M

更新日期：2016-06-01 00:00:00

abstract：:Sequestered from the action of complement, antibody and lytic peptides, phagosomal pathogens pose a unique problem for the innate immune system both in terms of detection and disposal. An immunologically induced 47-kDa (p47) GTPase family recruited to nascent phagosomes (PGs) has provided new insights into how vertebr...

journal_title：Current opinion in microbiology

authors： MacMicking JD

更新日期：2005-02-01 00:00:00

abstract：:High throughput, deep sequencing assays are powerful tools for gaining insights into virus-host interactions. Sequencing assays can discover novel viruses and describe the genomes of novel and known viruses. Genomic information can predict viral proteins that can be characterized, describe important genes in the host ...

journal_title：Current opinion in microbiology

authors： Wylie KM,Weinstock GM,Storch GA

更新日期：2013-08-01 00:00:00

abstract：:Phagocytic cells, including macrophages, neutrophils and dendritic cells, are critical components of the innate immune response to bacterial pathogens such as Salmonella typhimurium. These cells can have several roles during the early stage of an infection including controlling bacterial replication and producing cyto...

journal_title：Current opinion in microbiology

authors： Wick MJ

更新日期：2004-02-01 00:00:00

abstract：:Atomic force microscopy imaging and force spectroscopy have recently opened a range of novel applications in microbiology. During the past two years, rapid advances have been made using atomic force microscopy to visualize the surface structure of two-dimensional bacterial protein crystals, biofilms and individual cel...

journal_title：Current opinion in microbiology

authors： Dufrêne YF

更新日期：2003-06-01 00:00:00

abstract：:In the past year, our knowledge of type IV transporters of Gram-negative bacteria has further expanded. Advances include the discovery of additional members of this family of proteins, increased knowledge of the morphologies of type IV transporters, and a better understanding of the mechanisms by which macromolecules ...

journal_title：Current opinion in microbiology

authors： Burns DL

更新日期：1999-02-01 00:00:00

abstract：:There has been a dramatic increase in the number of completely sequenced bacterial genomes during the past two years as a result of the efforts both of public genome agencies and the pharmaceutical industry. The availability of completely sequenced genomes permits more systematic analyses of genes, evolution and genom...

journal_title：Current opinion in microbiology

authors： Brutlag DL

更新日期：1998-06-01 00:00:00

abstract：:The Gram-positive pathogen Staphylococcus aureus poses a serious risk to public health due to its prevalence as a commensal organism, its ability to cause a multitude of diseases, and the increasing incidence of antibiotic resistant strains. S. aureus infects diverse niches within vertebrates despite being challenged ...

journal_title：Current opinion in microbiology

authors： Hammer ND,Skaar EP

更新日期：2012-02-01 00:00:00

abstract：:The acquisition of drug resistance by Plasmodium falciparum has severely curtailed global efforts to control malaria. Our ability to define resistance has been greatly enhanced by recent advances in Plasmodium genetics and genomics. Sequencing and microarray studies have identified thousands of polymorphisms in the P....

journal_title：Current opinion in microbiology

authors： Ekland EH,Fidock DA

更新日期：2007-08-01 00:00:00

abstract：:The existence of bacterial clones was evident in early phenotypic studies that recognised high levels of similarity in geographically and temporally separated isolates. Multilocus sequence typing (MLST) has become the most common method for genetically characterizing clones of several bacterial pathogens, allowing the...

journal_title：Current opinion in microbiology

authors： Feil EJ,Enright MC

更新日期：2004-06-01 00:00:00

abstract：:The genomic revolution is fully upon us in 2006 and the pace of discovery is set to accelerate with the emergence of ultra-high-throughput sequencing technologies. Our complete genome collection of bacteria and archaea continues to grow in number and diversity, as genome sequencing is applied to an array of new proble...

journal_title：Current opinion in microbiology

authors： Field D,Wilson G,van der Gast C

更新日期：2006-10-01 00:00:00

abstract：:The protozoan parasite Trypanosoma brucei is the causative agent of African sleeping sickness and the wasting disease, nagana, in cattle. The parasite is transmitted to the mammalian host by the bite of a tsetse fly. These parasites lack transcriptional regulation, and their gene expression is mainly regulated post-tr...

journal_title：Current opinion in microbiology

authors： Michaeli S

更新日期：2014-08-01 00:00:00

abstract：:Infections caused by the apicomplexan parasites Plasmodium and Toxoplasma are wide-spread, life-threatening and therapeutically challenging. These pathogens are obligate intracellular microorganisms that invade mammalian cells by forming a self-made niche, the parasitophorous vacuole that is impervious to host lysosom...

journal_title：Current opinion in microbiology

authors： Coppens I

更新日期：2017-12-01 00:00:00

abstract：:Cryptosporidium is a leading cause of diarrhea and death in young children and untreated AIDS patients in resource-poor settings, and of waterborne outbreaks of disease in developed countries. However, there is no consistently effective treatment for vulnerable populations. Progress towards development of therapeutics...

journal_title：Current opinion in microbiology

authors： Bhalchandra S,Lamisere H,Ward H

更新日期：2020-12-01 00:00:00

abstract：:Metagenomics is a novel field which deals with the sequencing and study of microbial organisms or viruses isolated directly from a particular environment. This has already provided a wealth of information and new insights for the inhabitants of various environmental niches. For a given sample, one would like to determ...

journal_title：Current opinion in microbiology

authors： McHardy AC,Rigoutsos I

更新日期：2007-10-01 00:00:00

abstract：:Sensing its changing environment is key for Vibrio cholerae when making the transition from an aquatic lifestyle to one more suited to a human host. An inverse correlation between motility and virulence gene expression has been reported, with the NADH : ubiquinone oxidoreductase system which powers motility by generat...

journal_title：Current opinion in microbiology

authors： Krukonis ES,DiRita VJ

更新日期：2003-04-01 00:00:00

abstract：:The central role of small RNAs in regulating bacterial gene expression has been elucidated in the past years. Typically, small RNAs act via specific basepairing with target mRNAs, leading to modulation of translation initiation and mRNA stability. Quantitative studies suggest that small RNA regulation is characterized...

journal_title：Current opinion in microbiology

authors： Levine E,Hwa T

更新日期：2008-12-01 00:00:00

abstract：:The Saccharomyces cerevisiae genome sequence, augmented by new data on gene expression and function, continues to yield new findings about eukaryote genome evolution. Analysis of the duplicate gene pairs formed by whole-genome duplication indicates that selection for increased levels of gene expression was a significa...

journal_title：Current opinion in microbiology

authors： Seoighe C,Wolfe KH

更新日期：1999-10-01 00:00:00

abstract：:In Gram-negative bacteria such as Escherichia coli the peptidoglycan sacculus resides in the periplasm, a compartment that experiences changes in pH value, osmolality, ion strength and other parameters depending on the cell's environment. Hence, the cell needs robust peptidoglycan growth mechanisms to grow and divide ...

journal_title：Current opinion in microbiology

authors： Pazos M,Peters K,Vollmer W

更新日期：2017-04-01 00:00:00

abstract：:Antibiotics started to be used almost 90 years ago to eradicate life-threatening infections. The urgency of the problem required rapid, broad-spectrum elimination of infectious agents. Since their initial discovery, these antimicrobials have saved millions of lives. However, they are not exempt from side effects, whic...

journal_title：Current opinion in microbiology

authors： de la Fuente-Nunez C,Torres MD,Mojica FJ,Lu TK

更新日期：2017-06-01 00:00:00

abstract：:The recent discovery of binding protein dependent secondary transporters and the ever-growing family of membrane potential generating secondary transporters emphasize the diversity of transport systems in both the mechanistical and physiological sense. The vast amount of data on the lactose permease is now beginning t...

journal_title：Current opinion in microbiology

authors： Lolkema JS,Poolman B,Konings WN

更新日期：1998-04-01 00:00:00

abstract：:Mosquitoes are the major arthropod vectors of human diseases such as malaria and viral encephalitis. However, each mosquito species does not transmit every pathogen, owing to reasons that include specific evolutionary histories, mosquito immune system structure, and ecology. Even a competent vector species for a patho...

journal_title：Current opinion in microbiology

authors： Mitri C,Vernick KD

更新日期：2012-06-01 00:00:00

abstract：:Macrophages protect their host by engulfing foreign bodies within phagosomes that rapidly develop into microbicidal organelles. Numerous pathogens, such as species of Toxoplasma, Leishmania, Mycobacterium, Salmonella and Legionella, thrive in human macrophages, sometimes with disastrous effects. Defining the survival ...

journal_title：Current opinion in microbiology

authors： Amer AO,Swanson MS

更新日期：2002-02-01 00:00:00

abstract：:In filamentous fungi, the actin cytoskeleton is required for polarity establishment and maintenance at hyphal tips and for formation of a contractile ring at sites of septation. Recently, formins have been identified as Arp (actin-related protein) 2/3-independent nucleators of actin polymerization, and filamentous fun...

journal_title：Current opinion in microbiology

authors： Xiang X,Plamann M

更新日期：2003-12-01 00:00:00

abstract：:Analyses of the complex regulatory networks leading to T cell survival, death, and immune deficiency have been aided in the past year by the dramatic development of new technologies to identify T cells and assess T cell function. These new techniques have shown that functional inactivation and apoptotic elimination of...

journal_title：Current opinion in microbiology

authors： Welsh RM,McNally JM

更新日期：1999-08-01 00:00:00

abstract：:The opportunistic fungal pathogen Aspergillus fumigatus adapts to iron limitation by upregulation of iron uptake mechanisms including siderophore biosynthesis and downregulation of iron-consuming pathways to spare iron. These metabolic changes depend mainly on the transcription factor HapX. Consistent with the crucial...

journal_title：Current opinion in microbiology

authors： Schrettl M,Haas H

更新日期：2011-08-01 00:00:00

abstract：:The yeast Saccharomyces cerevisiae senses and responds to nutrients by adapting its growth rate and undergoing morphogenic transitions to ensure survival. The Tor pathway is a major integrator of nutrient-derived signals that in coordination with other signaling pathways orchestrates cell growth. Recent advances have ...

journal_title：Current opinion in microbiology

authors： Rohde JR,Bastidas R,Puria R,Cardenas ME

更新日期：2008-04-01 00:00:00

abstract：:Bacterium-host interactions are important for diverse ecological settings including pathogenicity and symbiosis. Electron cryotomography is a powerful method for studying the macromolecular complexes that mediate such interactions in situ. The main limitation of electron cryotomography is its restriction to relatively...

journal_title：Current opinion in microbiology

authors： Medeiros JM,Böck D,Pilhofer M

更新日期：2018-06-01 00:00:00