Yersinia versus host immunity: how a pathogen evades or triggers a protective response.

Abstract:

:The human pathogenic Yersinia species cause diseases that represent a significant source of morbidity and mortality. Despite this, specific mechanisms underlying Yersinia pathogenesis and protective host responses remain poorly understood. Recent studies have shown that Yersinia disrupt cell death pathways, perturb inflammatory processes and exploit immune cells to promote disease. The ensuing host responses following Yersinia infection include coordination of innate and adaptive immune responses in an attempt to control bacterial replication. Here, we highlight current advances in our understanding of the interactions between the pathogenic yersiniae and host cells, as well as the protective host responses mobilized to counteract these pathogens. Together, these studies enhance our understanding of Yersinia pathogenesis and highlight the ongoing battle between host and microbe.

journal_name

Curr Opin Microbiol

authors

Chung LK,Bliska JB

doi

10.1016/j.mib.2015.11.001

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

56-62

eissn

1369-5274

issn

1879-0364

pii

S1369-5274(15)00156-3

journal_volume

29

pub_type

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