Abstract:
:Inflammasomes - molecular platforms for caspase-1 activation - have emerged as common hubs for a number of pathways that detect and respond to bacterial pathogens. Caspase-1 activation results in the secretion of bioactive IL-1β and IL-18 and pyroptosis, and thus launches a systemic immune and inflammatory response. In this review we discuss signal transduction leading to 'canonical' and 'non-canonical' activation of caspase-1 through the involvement of upstream caspases. Recent studies have identified a growing number of regulatory networks involving guanylate binding proteins, protein kinases, ubiquitylation and necroptosis related pathways that modulate inflammasome responses and immunity to bacterial infection. By being able to respond to extracellular, vacuolar and cytosolic bacteria, their cytosolic toxins or ligands for cell surface receptors, inflammasomes have emerged as important sentinels of infection.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Eldridge MJ,Shenoy ARdoi
10.1016/j.mib.2014.10.008subject
Has Abstractpub_date
2015-02-01 00:00:00pages
32-41eissn
1369-5274issn
1879-0364pii
S1369-5274(14)00156-8journal_volume
23pub_type
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