Abstract:
:Fluency in a common language allows individuals to convey information and carry out complex activities that otherwise would be difficult or even impossible without the benefit of shared communication. Cyclic (di)nucleotides have recently been recognized as such an accessible language understood by both microbe and the host, ever since remarkable progresses have revealed the molecular details of these nucleotide second messengers used in cellular communication systems. Though undergoing separate evolutionary pathways in prokaryotes and eukaryotes, cyclic (di)nucleotides enable microbes to influence host cells immediately and fiercely by modulating a variety of cellular activities. Here we highlight recent insights in cyclic (di)nucleotides and focus on the balancing of these indispensable signaling molecules by synthases and phosphodiesterases.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Gao J,Tao J,Liang W,Jiang Zdoi
10.1016/j.mib.2015.12.005subject
Has Abstractpub_date
2016-04-01 00:00:00pages
79-87eissn
1369-5274issn
1879-0364pii
S1369-5274(15)00176-9journal_volume
30pub_type
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