Genome and transcriptome analyses of Leishmania spp.: opening Pandora's box.

abstract：:The concept of 'protein function' is rather 'fuzzy' because it is often based on whimsical terms or contradictory nomenclature. This currently presents a challenge for functional genomics because precise definitions are essential for most computational approaches. Addressing this challenge, the notion of networks betw...

journal_title：Current opinion in microbiology

authors： Jansen R,Gerstein M

更新日期：2004-10-01 00:00:00

abstract：:In two-component signaling systems, phosphorylated response regulators (RRs) are often dephosphorylated by their partner kinases in order to control the in vivo concentration of phospho-RR (RR approximately P). This activity is easily demonstrated in vitro, but these experiments have typically used very high concentra...

journal_title：Current opinion in microbiology

authors： Kenney LJ

更新日期：2010-04-01 00:00:00

abstract：:The enzymological and genetic aspects of microbial metabolism of hydrocarbons have been extensively revealed. Such molecular information is useful for understanding the bioremediation of oil spill environments and production of hydrocarbon-specific fine chemicals. ...

journal_title：Current opinion in microbiology

authors： Ishige T,Tani A,Sakai Y,Kato N

更新日期：2003-06-01 00:00:00

abstract：:According to a Pew Research study published in February 2015, there are 37 antibacterial programs currently in clinical trials in the United States. Protein structure-based methods for guiding small molecule design were used in at least 34 of these programs. Typically, this occurred at an early stage (drug discovery a...

journal_title：Current opinion in microbiology

authors： Staker BL,Buchko GW,Myler PJ

更新日期：2015-10-01 00:00:00

abstract：:Membrane shape is functionally linked with many cellular processes. The limiting membrane of vacuoles containing Toxoplasma gondii and Plasmodium apicomplexan parasites lies at the host-parasite interface. This membrane comprises intra-vacuolar and extra-vacuolar tubulo-vesicular deformations, which influence host-par...

journal_title：Current opinion in microbiology

authors： Santi-Rocca J,Blanchard N

更新日期：2017-12-01 00:00:00

abstract：:The recent discovery of binding protein dependent secondary transporters and the ever-growing family of membrane potential generating secondary transporters emphasize the diversity of transport systems in both the mechanistical and physiological sense. The vast amount of data on the lactose permease is now beginning t...

journal_title：Current opinion in microbiology

authors： Lolkema JS,Poolman B,Konings WN

更新日期：1998-04-01 00:00:00

abstract：:One current challenge in metabolic systems biology is to map out the regulation networks that control metabolism. From progress in this area, we conclude that non-transcriptional mechanisms (e.g. metabolite-protein interactions and protein phosphorylation) are highly relevant in actually controlling metabolic function...

journal_title：Current opinion in microbiology

authors： Heinemann M,Sauer U

更新日期：2010-06-01 00:00:00

abstract：:Macrophages protect their host by engulfing foreign bodies within phagosomes that rapidly develop into microbicidal organelles. Numerous pathogens, such as species of Toxoplasma, Leishmania, Mycobacterium, Salmonella and Legionella, thrive in human macrophages, sometimes with disastrous effects. Defining the survival ...

journal_title：Current opinion in microbiology

authors： Amer AO,Swanson MS

更新日期：2002-02-01 00:00:00

abstract：:Several species of Archaea are involved in symbiotic or parasitic associations with representatives of Eukarya, Bacteria and other Archaea. Eukaryal interactions include different members of methanogens, found in the gut of arthropods, in the rumen of cattle, and in the human intestine, while Cenarchaeum symbiosum is ...

journal_title：Current opinion in microbiology

authors： Moissl-Eichinger C,Huber H

更新日期：2011-06-01 00:00:00

abstract：:Gene clusters contributing to processes such as cell growth and pathogenicity are often controlled by two-component signal transduction systems (TCSs). Specific inhibitors against TCS systems work differently from conventional antibiotics, and developing them into new drugs that are effective against various drug-resi...

journal_title：Current opinion in microbiology

authors： Gotoh Y,Eguchi Y,Watanabe T,Okamoto S,Doi A,Utsumi R

更新日期：2010-04-01 00:00:00

abstract：:Bacteria utilize a diverse set of nucleotide second messengers to regulate cellular responses by binding macromolecular receptors (RNAs and proteins). Recent studies on cyclic di-GMP (c-di-GMP) have shown that this signaling molecule binds multiple receptors to regulate different steps in the same biological process. ...

journal_title：Current opinion in microbiology

authors： Orr MW,Galperin MY,Lee VT

更新日期：2016-12-01 00:00:00

abstract：:Viruses attach to specific receptors, but identified receptors are often absent from the epithelial surfaces where infections begin. Viruses can bind to alternative receptor molecules present on epithelial surfaces and they can enter hosts in ways that bypass mucosal barriers to infection. To understand how viruses cr...

journal_title：Current opinion in microbiology

authors： Bergelson JM

更新日期：2003-08-01 00:00:00

abstract：:Septins are cytoskeletal elements that contain a highly conserved canonical G domain flanked by more divergent N- and C-termini. Septin monomers form heteropolymers that in turn associate into a variety of higher-order structures. SUMOylation, acetylation and phosphorylation of septins have all been reported; however,...

journal_title：Current opinion in microbiology

authors： Hernández-Rodríguez Y,Momany M

更新日期：2012-12-01 00:00:00

abstract：:Photodynamic therapy (PDT) uses photosensitizers (non-toxic dyes) that are activated by absorption of visible light to form reactive oxygen species (including singlet oxygen) that can oxidize biomolecules and destroy cells. Antimicrobial photodynamic inactivation (aPDI) can treat localized infections. aPDI neither cau...

journal_title：Current opinion in microbiology

authors： Hamblin MR

更新日期：2016-10-01 00:00:00

abstract：:Wastewater bioreactors have been used to treat domestic and industrial waste for nearly a century. Development of molecular tools such as PCR and DNA microarrays have enabled identification and characterization of some of the microbes in these bioreactors; however, molecular characterization of the microbes is still i...

journal_title：Current opinion in microbiology

authors： Bramucci M,Nagarajan V

更新日期：2006-06-01 00:00:00

abstract：:While natural microbial communities are composed of a mix of microbes with often unknown functions, the construction of synthetic microbial communities allows for the generation of defined systems with reduced complexity. Used in a top-down approach, synthetic communities serve as model systems to ask questions about ...

journal_title：Current opinion in microbiology

authors： Grosskopf T,Soyer OS

更新日期：2014-04-01 00:00:00

abstract：:Pneumococcal conjugate vaccine is not only effective against invasive and non-invasive disease in all ages but also has a significant impact on antibiotic-resistant infections since a number of resistant serotypes are targeted by the vaccine. Surveillance studies in the post-licensure years have shown an increase in n...

journal_title：Current opinion in microbiology

authors： McGee L

更新日期：2007-10-01 00:00:00

abstract：:The environment is suffused with nearly countless types of fungi, and our immune systems must be tuned to cope with constant exposure to them. In addition, it is becoming increasingly clear that many surfaces of our bodies are colonized with complex populations of fungi (the mycobiome) in the same way that they are co...

journal_title：Current opinion in microbiology

authors： Iliev ID,Underhill DM

更新日期：2013-06-01 00:00:00

abstract：:Candida albicans is a regular member of the intestinal microbiota in the majority of the human population. This underscores C. albicans' adaptation to life in the intestine without inducing competitive interactions with other microbes, or immune responses detrimental to its survival. However, specific conditions such ...

journal_title：Current opinion in microbiology

authors： Kumamoto CA,Gresnigt MS,Hube B

更新日期：2020-08-01 00:00:00

abstract：:In filamentous fungi, the actin cytoskeleton is required for polarity establishment and maintenance at hyphal tips and for formation of a contractile ring at sites of septation. Recently, formins have been identified as Arp (actin-related protein) 2/3-independent nucleators of actin polymerization, and filamentous fun...

journal_title：Current opinion in microbiology

authors： Xiang X,Plamann M

更新日期：2003-12-01 00:00:00

abstract：:Enteropathogenic Yersinia species encode invasin, which promotes uptake into host cells by binding beta1 integrins. Invasin may cluster integrin heterodimers extracellularly and cause the integrin alpha and beta chains to splay apart in the cytoplasm. Cdc42 signaling is not essential for Yersinia uptake, whereas invas...

journal_title：Current opinion in microbiology

authors： Wong KW,Isberg RR

更新日期：2005-02-01 00:00:00

abstract：:The emerging human pathogen Bartonella henselae has the remarkable capacity to colonise vascular tissues and to stimulate vasoproliferative tumour growth. Although the molecular principle of bacterium-induced neovascularisation (angiogenesis) is still unclear, recent studies have indicated a novel mechanism of endothe...

journal_title：Current opinion in microbiology

authors： Dehio C

更新日期：1999-02-01 00:00:00

abstract：:Endolysins are phage-encoded enzymes that break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. Their action is tightly regulated by holins, by membrane arrest, and by conversion from their inactive to active state. Recent research has not only revealed the unexpected diversity of t...

journal_title：Current opinion in microbiology

authors： Loessner MJ

更新日期：2005-08-01 00:00:00

abstract：:Research into the mechanisms regulating bacterial cell size has its origins in a single paper published over 50 years ago. In it Schaechter and colleagues made the observation that the chemical composition and size of a bacterial cell is a function of growth rate, independent of the medium used to achieve that growth ...

journal_title：Current opinion in microbiology

authors： Vadia S,Levin PA

更新日期：2015-04-01 00:00:00

abstract：:Single microbial cells can now be sequenced using DNA amplified by the Multiple Displacement Amplification (MDA) reaction. The few femtograms of DNA in a bacterium are amplified into micrograms of high molecular weight DNA suitable for DNA library construction and Sanger sequencing. The MDA-generated DNA also performs...

journal_title：Current opinion in microbiology

authors： Lasken RS

更新日期：2007-10-01 00:00:00

abstract：:Associations between marine invertebrates and their cooperative bacterial symbionts offer access to an understanding of the roots of host-microbe interaction; for example, several symbioses like the squid-vibrio light organ association serve as models for investigating how each partner affects the developmental biolog...

journal_title：Current opinion in microbiology

authors： McFall-Ngai MJ,Ruby EG

更新日期：2000-12-01 00:00:00

abstract：:Recent studies have led to the identification of more than 50 small regulatory RNAs in Escherichia coli. Only a subset of these RNAs has been characterized. However, it is clear that many of the RNAs, such as the MicF, OxyS, DsrA, Spot42 and RyhB RNAs, act by basepairing to activate or repress translation or to destab...

journal_title：Current opinion in microbiology

authors： Storz G,Opdyke JA,Zhang A

更新日期：2004-04-01 00:00:00

abstract：:Host social interactions can provide multiple complex pathways for microbial transmission. Here, we suggest non-human primates as models to study the social transmission of commensal or mutualistic microbes due to their high sociality, wide range of group compositions and dominance structures, and diverse group intera...

journal_title：Current opinion in microbiology

authors： Kuthyar S,Manus MB,Amato KR

更新日期：2019-08-01 00:00:00

abstract：:Staphylococcus aureus is a leading cause of hospital-acquired and often persistent infections. A key feature of pathogenic S. aureus is the expression of an array of extracellular matrix-binding proteins. In particular, the fibronectin-binding proteins FnBP-A and FnBP-B afford the pathogen the ability to connect to ce...

journal_title：Current opinion in microbiology

authors： Hauck CR,Ohlsen K

更新日期：2006-02-01 00:00:00

abstract：:The human body comprises of micro-ecosystem made up of trillions of microbes (i.e. bacteria, archaea, fungi, protists and viruses). The total microbial gene content, which is referred to as the human microbiome, is fundamental to human physiology and immunity. There exists an intricate relationship between the surroun...

journal_title：Current opinion in microbiology

authors： Sharma A,Gilbert JA

更新日期：2018-08-01 00:00:00