Abstract:
:Bacteria utilize a diverse set of nucleotide second messengers to regulate cellular responses by binding macromolecular receptors (RNAs and proteins). Recent studies on cyclic di-GMP (c-di-GMP) have shown that this signaling molecule binds multiple receptors to regulate different steps in the same biological process. We propose this property of the same molecule regulating multiple steps in the same process is biologically meaningful and have termed this phenomenon 'sustained sensing'. Here, we discuss the recent findings that support the concept of sustained sensing of c-di-GMP levels and provide additional examples that support the utilization of sustained sensing by other second messengers. Sustained sensing may be widespread in bacteria and provides an additional level of complexity in prokaryotic signal transduction networks.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Orr MW,Galperin MY,Lee VTdoi
10.1016/j.mib.2016.08.010subject
Has Abstractpub_date
2016-12-01 00:00:00pages
119-126eissn
1369-5274issn
1879-0364pii
S1369-5274(16)30127-8journal_volume
34pub_type
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