P. aeruginosa quorum-sensing systems and virulence.

Abstract:

:Quorum sensing is an important mechanism for the regulation of genes in many Gram-negative and Gram-positive bacteria. In the opportunistic pathogen Pseudomonas aeruginosa, the absence of one or more components of the quorum-sensing system results in a significant reduction in virulence. Recent advances in the past year have demonstrated that the quorum-sensing signal molecule 3O-C(12)-HSL is also a potent stimulator of multiple eukaryotic cells and thus may alter the host response during P. aeruginosa infections. Therefore, via the regulation of multiple factors and the production of 3O-C(12)-HSL, quorum-sensing systems have a significant effect on the virulence of the bacteria and also on how the host responds to P. aeruginosa infections.

journal_name

Curr Opin Microbiol

authors

Smith RS,Iglewski BH

doi

10.1016/s1369-5274(03)00008-0

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

56-60

issue

1

eissn

1369-5274

issn

1879-0364

pii

S1369527403000080

journal_volume

6

pub_type

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