P. aeruginosa quorum-sensing systems and virulence.

abstract：:Endosymbiotic theory goes back over 100 years. It explains the similarity of chloroplasts and mitochondria to free-living prokaryotes by suggesting that the organelles arose from prokaryotes through (endo)symbiosis. Gene trees provide important evidence in favour of symbiotic theory at a coarse-grained level, but the ...

journal_title：Current opinion in microbiology

authors： Zimorski V,Ku C,Martin WF,Gould SB

更新日期：2014-12-01 00:00:00

abstract：:The emerging human pathogen Bartonella henselae has the remarkable capacity to colonise vascular tissues and to stimulate vasoproliferative tumour growth. Although the molecular principle of bacterium-induced neovascularisation (angiogenesis) is still unclear, recent studies have indicated a novel mechanism of endothe...

journal_title：Current opinion in microbiology

authors： Dehio C

更新日期：1999-02-01 00:00:00

abstract：:Application of metagenomic functional selections to study antibiotic resistance genes is revealing a highly diverse and complex network of genetic exchange between bacterial pathogens and environmental reservoirs, which likely contributes significantly to increasing resistance levels in pathogens. In some cases, clini...

journal_title：Current opinion in microbiology

authors： Dantas G,Sommer MO

更新日期：2012-10-01 00:00:00

abstract：:Legionella pneumophila is a water-borne opportunistic pathogen causing a life-threatening pneumonia called 'Legionnaires' disease'. The Legionella quorum sensing (Lqs) system produces and responds to the α-hydroxyketone signaling molecule 3-hydroxypentadecane-4-one (Legionella autoinducer-1, LAI-1). The Lqs system con...

journal_title：Current opinion in microbiology

authors： Personnic N,Striednig B,Hilbi H

更新日期：2018-02-01 00:00:00

abstract：:We postulate that phenotypic resistance to antibiotics, persistence, is not an evolved (selected-for) character but rather like mutation, an inadvertent product of different kinds of errors and glitches. The rate of generation of these errors is augmented by exposure to these drugs. The genes that have been identified...

journal_title：Current opinion in microbiology

authors： Levin BR,Concepción-Acevedo J,Udekwu KI

更新日期：2014-10-01 00:00:00

abstract：:A combination of structural, biochemical and functional studies with the flavivirus tick-borne encephalitis virus has revealed the characteristics of a new class of viral fusion protein, class II, that is unrelated to the class I viral fusion proteins for which influenza virus hemagglutinin is the prototype. New struc...

journal_title：Current opinion in microbiology

authors： Heinz FX,Allison SL

更新日期：2001-08-01 00:00:00

abstract：:All organisms must secure essential trace nutrients, including iron, zinc, manganese and copper for survival and proliferation. However, these very nutrients are also highly toxic if present at elevated levels. Mammalian immunity has harnessed both the essentiality and toxicity of micronutrients to defend against micr...

journal_title：Current opinion in microbiology

authors： Ballou ER,Wilson D

更新日期：2016-08-01 00:00:00

abstract：:The Gram-positive pathogen Staphylococcus aureus poses a serious risk to public health due to its prevalence as a commensal organism, its ability to cause a multitude of diseases, and the increasing incidence of antibiotic resistant strains. S. aureus infects diverse niches within vertebrates despite being challenged ...

journal_title：Current opinion in microbiology

authors： Hammer ND,Skaar EP

更新日期：2012-02-01 00:00:00

abstract：:Virulence gene regulators RovA, SlyA and PecS comprise a subset of the MarR/SlyA family of transcriptional regulators, which has been shown to be involved in the regulation of virulence genes. These regulators have all been shown to both positively and negatively regulate the expression of multiple genes, involving se...

journal_title：Current opinion in microbiology

authors： Ellison DW,Miller VL

更新日期：2006-04-01 00:00:00

abstract：:Most Candida albicans strains are heterozygous at the MTL (mating-type-like) locus, but mating occurs in hemi- or homozygous strains. The white-opaque switch process is repressed by the heterodimer of the MTLa1 and MTLalpha2 gene products, while mating genes are induced by a2 and alpha1. Mating occurs in opaque cells ...

journal_title：Current opinion in microbiology

authors： Magee PT,Magee BB

更新日期：2004-12-01 00:00:00

abstract：:Biofilm development and quorum sensing (QS) are closely interconnected processes. Biofilm formation is a cooperative group behaviour that involves bacterial populations living embedded in a self-produced extracellular matrix. QS is a cell-cell communication mechanism that synchronizes gene expression in response to po...

journal_title：Current opinion in microbiology

authors： Solano C,Echeverz M,Lasa I

更新日期：2014-04-01 00:00:00

abstract：:Biofilms are a typical mode of growth for most microorganisms and provide them with a variety of survival benefits. Biofilms can pose medical and industrial challenges due to their increased tolerance of antimicrobials and disinfectants. Exposure of bacteria to subinhibitory concentrations of those compounds can furth...

journal_title：Current opinion in microbiology

authors： Ranieri MR,Whitchurch CB,Burrows LL

更新日期：2018-10-01 00:00:00

abstract：:Following concerns over the potential for insect resistance to insecticidal Bacillus thuringiensis toxins expressed in transgenic plants, there has been recent interest in novel biological insecticides. Over the past year there has been considerable progress in the cloning of several alternative toxin genes from the b...

journal_title：Current opinion in microbiology

authors： ffrench-Constant R,Bowen D

更新日期：1999-06-01 00:00:00

abstract：:The glideosome is a unique attribute of the Apicomplexa phylum. This myosin-based machine powers parasite motility, migration across biological barriers, host cell invasion and egress from infected cells. The timing, duration and orientation of gliding motility are tightly regulated to assure establishment of infectio...

journal_title：Current opinion in microbiology

authors： Daher W,Soldati-Favre D

更新日期：2009-08-01 00:00:00

abstract：:Antibiotic lethality is a complex physiological process, sensitive to external cues. Recent advances using systems approaches have revealed how events downstream of primary target inhibition actively participate in antibiotic death processes. In particular, altered metabolism, translational stress and DNA damage each ...

journal_title：Current opinion in microbiology

authors： Yang JH,Bening SC,Collins JJ

更新日期：2017-10-01 00:00:00

abstract：:Microbial growth can be characterized by a limited set of macroscopic parameters such as growth rate, biomass yield and substrate affinity. Different culturing protocols for laboratory evolution have been developed to select mutant strains that have one specific macroscopic growth parameter improved. Some of those mut...

journal_title：Current opinion in microbiology

authors： Bachmann H,Bruggeman FJ,Molenaar D,Branco Dos Santos F,Teusink B

更新日期：2016-06-01 00:00:00

abstract：:During the past ten years, species-rich nations in the developing world have sought to capitalize on their 'biological patrimony' through a variety of business relationships with multinational corporations as a means of underwriting their conservation efforts. Initially lauded, these relationships have generated more ...

journal_title：Current opinion in microbiology

authors： Garrity GM,Hunter-Cevera J

更新日期：1999-06-01 00:00:00

abstract：:Inducible tolerance to acidic and alkaline environments is recognized as an important survival strategy for many prokaryotic and eukaryotic microorganisms. Recent developments in understanding this phenomenon include the identification of regulatory genes, specific tolerance mechanisms and genes associated with tolera...

journal_title：Current opinion in microbiology

authors： Foster JW

更新日期：1999-04-01 00:00:00

abstract：:The post-translational attachment of ubiquitin or ubiquitin-like modifiers (ULMs) to proteins regulates many cellular processes including the generation of innate and adaptive immune responses to pathogens. Vice versa, pathogens counteract immune defense by inhibiting or redirecting the ubiquitination machinery of the...

journal_title：Current opinion in microbiology

authors： Viswanathan K,Früh K,DeFilippis V

更新日期：2010-08-01 00:00:00

abstract：:Impaired microbiome diversity and composition can develop into a potent etiological agent of disease and increase susceptibility to infection. Given this, interventions targeting the microbiome have developed rapidly, with healthy donor feces being a de facto source of beneficial communities employed to rebalance pati...

journal_title：Current opinion in microbiology

authors： Kaakoush NO

更新日期：2020-08-01 00:00:00

abstract：:Major advances have been made in the past five years in the identification of cellular targets of toxins produced by anaerobic bacteria. These targets include the vesicular membrane docking and fusion apparatus, the actin cytoskeleton, the signal transduction machinery and the cell membrane. The recent discovery that ...

journal_title：Current opinion in microbiology

authors： Boquet P,Munro P,Fiorentini C,Just I

更新日期：1998-02-01 00:00:00

abstract：:Recent studies have led to the identification of more than 50 small regulatory RNAs in Escherichia coli. Only a subset of these RNAs has been characterized. However, it is clear that many of the RNAs, such as the MicF, OxyS, DsrA, Spot42 and RyhB RNAs, act by basepairing to activate or repress translation or to destab...

journal_title：Current opinion in microbiology

authors： Storz G,Opdyke JA,Zhang A

更新日期：2004-04-01 00:00:00

abstract：:Mast cells (MCs) have been implicated in orchestrating the host's early innate immune and adaptive immune responses in several models of acute bacterial infections. Most of this activity results in early clearance of the bacteria and timely resolution of infection. However, during chronic infections because of the pro...

journal_title：Current opinion in microbiology

authors： Chan CY,St John AL,Abraham SN

更新日期：2012-02-01 00:00:00

abstract：:Since the publication of the complete genome sequence of Mycobacterium tuberculosis in 1998, there has been a marked intensification and diversification of activities in the field of tuberculosis research. Among the areas that have advanced spectacularly are comparative genomics, functional genomics-notably the study ...

journal_title：Current opinion in microbiology

authors： Domenech P,Barry CE 3rd,Cole ST

更新日期：2001-02-01 00:00:00

abstract：:Macrophages protect their host by engulfing foreign bodies within phagosomes that rapidly develop into microbicidal organelles. Numerous pathogens, such as species of Toxoplasma, Leishmania, Mycobacterium, Salmonella and Legionella, thrive in human macrophages, sometimes with disastrous effects. Defining the survival ...

journal_title：Current opinion in microbiology

authors： Amer AO,Swanson MS

更新日期：2002-02-01 00:00:00

abstract：:One defining feature of apicomplexan parasites is their special ability to actively invade host cells. Although rapid, invasion is a complicated process that requires coordinated activities of host cell attachment, protein secretion, and motility by the parasite. Central to this process is the establishment of a struc...

journal_title：Current opinion in microbiology

authors： Shen B,Sibley LD

更新日期：2012-08-01 00:00:00

abstract：:Since the past decades, oligosaccharides are considered for their potential biological activities. To exploit them, it was essential to obtain pure molecules in large amounts. Several strategies were developed to produce specific sugar sequences with specific substitution patterns from land plants and algae polysaccha...

journal_title：Current opinion in microbiology

authors： Courtois J

更新日期：2009-06-01 00:00:00

abstract：:The Saccharomyces cerevisiae genome sequence, augmented by new data on gene expression and function, continues to yield new findings about eukaryote genome evolution. Analysis of the duplicate gene pairs formed by whole-genome duplication indicates that selection for increased levels of gene expression was a significa...

journal_title：Current opinion in microbiology

authors： Seoighe C,Wolfe KH

更新日期：1999-10-01 00:00:00

abstract：:Much of what we know about cytokinesis in bacteria has come from studies with Escherichia coli, and efforts to comprehensively understand this fundamental process in this organism continue to intensify. Major recent advances include in vitro assembly of a membrane-tethered version of FtsZ into contractile rings in lip...

journal_title：Current opinion in microbiology

authors： de Boer PA

更新日期：2010-12-01 00:00:00

abstract：:In the study of transmembrane transport, molecular phylogeny provides a reliable guide to protein structure, catalytic and noncatalytic transport mechanisms, mode of energy coupling and substrate specificity. It also allows prediction of the evolutionary history of a transporter family, leading to estimations of its a...

journal_title：Current opinion in microbiology

authors： Saier MH

更新日期：1999-10-01 00:00:00