Abstract:
:Gene clusters contributing to processes such as cell growth and pathogenicity are often controlled by two-component signal transduction systems (TCSs). Specific inhibitors against TCS systems work differently from conventional antibiotics, and developing them into new drugs that are effective against various drug-resistant bacteria may be possible. Furthermore, inhibitors of TCSs that control virulence factors may reduce virulence without killing the pathogenic bacteria. Previous TCS inhibitors targeting the kinase domain of the histidine kinase sensor suffered from poor selectivity. Recent TCS inhibitors, however, target the sensory domains of the sensors blocking the quorum sensing system, or target the essential response regulator. These new targets are introduced, together with several specific TCSs that have the potential to serve as effective drug targets.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Gotoh Y,Eguchi Y,Watanabe T,Okamoto S,Doi A,Utsumi Rdoi
10.1016/j.mib.2010.01.008subject
Has Abstractpub_date
2010-04-01 00:00:00pages
232-9issue
2eissn
1369-5274issn
1879-0364pii
S1369-5274(10)00013-5journal_volume
13pub_type
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