Abstract:
:Arginine is an integral part of host defense when invading pathogens are encountered. The arginine metabolite nitric oxide (NO) confers antimicrobial properties, whereas the metabolite ornithine is utilized for polyamine synthesis. Polyamines are crucial to tissue repair and anti-inflammatory responses. iNOS/arginase balance can determine Th1/Th2 response. Furthermore, the host arginine pool and its metabolites are utilized as energy sources by various pathogens. Apart from its role as an immune modulator, recent studies have also highlighted the therapeutic effects of arginine. This article sheds light upon the roles of arginine metabolism during pathological conditions and its therapeutic potential.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Gogoi M,Datey A,Wilson KT,Chakravortty Ddoi
10.1016/j.mib.2015.10.005subject
Has Abstractpub_date
2016-02-01 00:00:00pages
43-8eissn
1369-5274issn
1879-0364pii
S1369-5274(15)00153-8journal_volume
29pub_type
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2007.05.018
更新日期:2007-08-01 00:00:00
abstract::Associations between marine invertebrates and their cooperative bacterial symbionts offer access to an understanding of the roots of host-microbe interaction; for example, several symbioses like the squid-vibrio light organ association serve as models for investigating how each partner affects the developmental biolog...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2014.09.008
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
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abstract::Kinetoplastid parasites adapt to different environments with wide-reaching control of gene expression, but transcription of nuclear protein-coding genes is polycistronic: there is no individual control of transcription initiation. Mature mRNAs are made by co-transcriptional trans splicing and polyadenylation, and comp...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2016.04.018
更新日期:2016-08-01 00:00:00
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2016.05.015
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2019.08.004
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
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abstract::Protozoan pathogens have evolved countermeasures to avoid immune clearance and prolong the period of infection in their vertebrate hosts. The type and degree of immune escape strategies depends on the in vivo 'lifestyle' the pathogen has adopted. Here we describe how parasites use different strategies to coordinate th...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2009.08.001
更新日期:2009-10-01 00:00:00
abstract::Wild Escherichia coli are superbly adapted to survive in the intestines of their mammalian hosts and in the environment. E. coli K12 derivative (MG1655) encodes 4288 potential genes that provide the background genetic framework of this species. Particular E. coli clonal types encode additional chromosomal and extrachr...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2010.01.008
更新日期:2010-04-01 00:00:00
abstract::Natural prokaryotic populations are composed of multiple clonal lineages that are different in their core genomes in a range that varies typically between 95 and 100% nucleotide identity. Each clonal lineage also carries a complement of not shared flexible genes that can be very large. The compounded flexible genome p...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
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更新日期:2012-06-01 00:00:00
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2013.09.005
更新日期:2013-12-01 00:00:00
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journal_title:Current opinion in microbiology
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