Peptidoglycan hydrolases, bacterial shape, and pathogenesis.

Abstract:

:Bacterial shape has always been hypothesized to play an important role in the biology of a species and in the ability of certain bacteria to influence human health. The recent discovery of peptidoglycan hydrolases that modulate shape has now allowed this hypothesis to be addressed directly. Genetic, biochemical, and phenotypic studies have found that changes in shape and underlying peptidoglycan structure influence many pathogenic attributes including surviving unfavorable conditions, predation, transmission, colonization, and host interactions. The diversity of bacterial shapes, niches, and lifestyles is also reflected in diverse mechanisms of hydrolase regulation, critical for maintaining peptidoglycan integrity and biological properties of the cell. Future studies will build on the current work described and further elucidate the intersection of peptidoglycan hydrolase activity, shape, and disease outcome.

journal_name

Curr Opin Microbiol

authors

Frirdich E,Gaynor EC

doi

10.1016/j.mib.2013.09.005

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

767-78

issue

6

eissn

1369-5274

issn

1879-0364

pii

S1369-5274(13)00156-2

journal_volume

16

pub_type

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