Peptidoglycan hydrolases, bacterial shape, and pathogenesis.


:Bacterial shape has always been hypothesized to play an important role in the biology of a species and in the ability of certain bacteria to influence human health. The recent discovery of peptidoglycan hydrolases that modulate shape has now allowed this hypothesis to be addressed directly. Genetic, biochemical, and phenotypic studies have found that changes in shape and underlying peptidoglycan structure influence many pathogenic attributes including surviving unfavorable conditions, predation, transmission, colonization, and host interactions. The diversity of bacterial shapes, niches, and lifestyles is also reflected in diverse mechanisms of hydrolase regulation, critical for maintaining peptidoglycan integrity and biological properties of the cell. Future studies will build on the current work described and further elucidate the intersection of peptidoglycan hydrolase activity, shape, and disease outcome.


Curr Opin Microbiol


Frirdich E,Gaynor EC




Has Abstract


2013-12-01 00:00:00














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    authors: Ballou ER,Wilson D

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    journal_title:Current opinion in microbiology

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    authors: Kotb M

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    abstract::The existence of bacterial clones was evident in early phenotypic studies that recognised high levels of similarity in geographically and temporally separated isolates. Multilocus sequence typing (MLST) has become the most common method for genetically characterizing clones of several bacterial pathogens, allowing the...

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    authors: Mascher T

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    authors: Pratt LA,Kolter R

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    authors: Piddock LJ

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