The role of 'eat-me' signals and autophagy cargo receptors in innate immunity.

Abstract:

:Selective autophagy is an important effector mechanism of cell autonomous immunity, in particular against invasive bacterial species. Anti-bacterial autophagy is activated by rupture of bacteria-containing vacuoles and exposure of bacteria to the cytosol. The autophagy cargo receptors p62, NDP52 and Optineurin detect incoming bacteria that have become associated with specific 'eat-me' signals such as Galectin-8 and poly-ubiquitin and feed them into the autophagy pathway via interactions with phagophore-associated ATG8-like proteins. Here we review recent progress in the field regarding the origin of bacteria-associated 'eat-me' signals, the specific roles of individual cargo receptors and how disrupting cargo receptor function may be important for bacterial evasion of autophagy.

journal_name

Curr Opin Microbiol

authors

Boyle KB,Randow F

doi

10.1016/j.mib.2013.03.010

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

339-48

issue

3

eissn

1369-5274

issn

1879-0364

pii

S1369-5274(13)00045-3

journal_volume

16

pub_type

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