Abstract:
:The proposed order Megavirales comprises the nucleocytoplasmic large DNA viruses (NCLDV), infecting a wide range of hosts. Over time, they co-evolved with different host cells, developing various strategies to penetrate them. Mimiviruses and other giant viruses enter cells through phagocytosis, while Marseillevirus and other large viruses explore endocytosis and macropinocytosis. These differing strategies might reflect the evolution of those viruses. Various scenarios have been proposed for the origin and evolution of these viruses, presenting one of the most enigmatic issues to surround these microorganisms. In this context, we believe that giant viruses evolved independently by massive gene/size gain, exploring the phagocytic pathway of entry into amoebas. In response to gigantism, hosts developed mechanisms to evade these parasites.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Rodrigues RAL,Abrahão JS,Drumond BP,Kroon EGdoi
10.1016/j.mib.2016.03.009subject
Has Abstractpub_date
2016-06-01 00:00:00pages
88-93eissn
1369-5274issn
1879-0364pii
S1369-5274(16)30024-8journal_volume
31pub_type
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