Abstract：
:Streptococcus agalactiae (group B Streptococcus, GBS), a normal constituent of the intestinal microbiota is the major cause of human neonatal infections and a worldwide spread 'hypervirulent' clone, GBS ST-17, is strongly associated with neonatal meningitis. Adhesion to epithelial and endothelial cells constitutes a key step of the infectious process. Therefore GBS surface-anchored proteins are obvious potential adhesion mediators of barrier crossing and determinant of hypervirulence. This review addresses the most recent molecular insights gained from studies on GBS surface proteins proven to be involved in the crossing of the brain-blood barrier and emphasizes on the specificity of a hypervirulent clone that displays meningeal tropism.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Tazi A,Bellais S,Tardieux I,Dramsi S,Trieu-Cuot P,Poyart Cdoi
10.1016/j.mib.2011.12.002subject
Has Abstractpub_date
2012-02-01 00:00:00pages
44-9issue
1eissn
1369-5274issn
1879-0364pii
S1369-5274(11)00211-6journal_volume
15pub_type
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journal_title：Current opinion in microbiology
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