Bacterial-induced cell reprogramming to stem cell-like cells: new premise in host-pathogen interactions.

abstract：:Germ line encoded antiviral defenses in vertebrate cells tend to be either broadly acting factors that exploit general features of viral replication or effectors with strong pathogen preference by virtue of specific recognition of viral proteins. The Mx GTPases, however, are atypical since they have broad antiviral ac...

journal_title：Current opinion in microbiology

authors： Mitchell PS,Emerman M,Malik HS

更新日期：2013-08-01 00:00:00

abstract：:In contrast to obligate pathogens opportunistic pathogens such as Aspergillus fumigatus do not need a specific host to propagate or survive. However several characteristics of the saprophytic life-style and the selective pressure encountered in the primary ecological niche contribute to the virulence of A. fumigatus. ...

journal_title：Current opinion in microbiology

authors： Blatzer M,Latgé JP

更新日期：2017-12-01 00:00:00

abstract：:Microbial growth can be characterized by a limited set of macroscopic parameters such as growth rate, biomass yield and substrate affinity. Different culturing protocols for laboratory evolution have been developed to select mutant strains that have one specific macroscopic growth parameter improved. Some of those mut...

journal_title：Current opinion in microbiology

authors： Bachmann H,Bruggeman FJ,Molenaar D,Branco Dos Santos F,Teusink B

更新日期：2016-06-01 00:00:00

abstract：:The emerging human pathogen Bartonella henselae has the remarkable capacity to colonise vascular tissues and to stimulate vasoproliferative tumour growth. Although the molecular principle of bacterium-induced neovascularisation (angiogenesis) is still unclear, recent studies have indicated a novel mechanism of endothe...

journal_title：Current opinion in microbiology

authors： Dehio C

更新日期：1999-02-01 00:00:00

abstract：:Septins are cytoskeletal elements that contain a highly conserved canonical G domain flanked by more divergent N- and C-termini. Septin monomers form heteropolymers that in turn associate into a variety of higher-order structures. SUMOylation, acetylation and phosphorylation of septins have all been reported; however,...

journal_title：Current opinion in microbiology

authors： Hernández-Rodríguez Y,Momany M

更新日期：2012-12-01 00:00:00

abstract：:The détente between pathogen and host has been of keen interest to researchers in spite of being exceedingly difficult to probe. Recently, new RNA interference (RNAi) technologies, in particular in Drosophila tissue culture cells, have made it possible to interrogate the genetics of host organisms rapidly, with nearly...

journal_title：Current opinion in microbiology

authors： Cherry S

更新日期：2008-06-01 00:00:00

abstract：:Bacterial two-component systems (TCSs) and small regulatory RNAs (sRNAs) form densely interconnected networks that integrate and transduce information from the environment into fine-tuned changes of gene expression. Many TCSs control target genes indirectly through regulation of sRNAs, which in turn regulate gene expr...

journal_title：Current opinion in microbiology

authors： Göpel Y,Görke B

更新日期：2012-04-01 00:00:00

abstract：:In the past year, our knowledge of type IV transporters of Gram-negative bacteria has further expanded. Advances include the discovery of additional members of this family of proteins, increased knowledge of the morphologies of type IV transporters, and a better understanding of the mechanisms by which macromolecules ...

journal_title：Current opinion in microbiology

authors： Burns DL

更新日期：1999-02-01 00:00:00

abstract：:Recent work has shown that Immunoglobulin-like (Ig-like) domains occur frequently on the surface of tailed dsDNA bacteriophages. Several of these Ig-like domains are added to bacteriophage structural proteins via programmed ribosomal frameshifts, and their evolutionary patterns suggest that they can be exchanged by ho...

journal_title：Current opinion in microbiology

authors： Fraser JS,Maxwell KL,Davidson AR

更新日期：2007-08-01 00:00:00

abstract：:Since the publication of the complete genome sequence of Mycobacterium tuberculosis in 1998, there has been a marked intensification and diversification of activities in the field of tuberculosis research. Among the areas that have advanced spectacularly are comparative genomics, functional genomics-notably the study ...

journal_title：Current opinion in microbiology

authors： Domenech P,Barry CE 3rd,Cole ST

更新日期：2001-02-01 00:00:00

abstract：:Molecular phylogenetic studies reveal that many endosymbioses between bacteria and invertebrate hosts result from ancient infections followed by strict vertical transmission within host lineages. Endosymbionts display a distinctive constellation of genetic properties including AT-biased base composition, accelerated s...

journal_title：Current opinion in microbiology

authors： Moran NA,Baumann P

更新日期：2000-06-01 00:00:00

abstract：:Two-thirds of all bacterial genomes sequenced to-date possess an organelle for locomotion, referred to as flagella, periplasmic flagella or type IV pili. These genomes may also contain a chemotaxis-signaling system which governs flagellar rotation, thus leading a coordinated function for motility. Motility and chemota...

journal_title：Current opinion in microbiology

authors： Motaleb MA,Liu J,Wooten RM

更新日期：2015-12-01 00:00:00

abstract：:Pseudogenes are defined as fragments of once-functional genes that have been silenced by one or more nonsense, frameshift or missense mutations. Despite continuing increases in the speed of sequencing and annotating bacterial genomes, the identification and categorisation of pseudogenes remains problematic. Even when ...

journal_title：Current opinion in microbiology

authors： Goodhead I,Darby AC

更新日期：2015-02-01 00:00:00

abstract：:Successful execution of differentiation programs requires cells to assess multitudes of internal and external cues and respond with appropriate gene expression programs. Here, we review how Bacillus subtilis sporulation network deals with these tasks focusing on the lessons generalizable to other systems. With feedfor...

journal_title：Current opinion in microbiology

authors： Narula J,Fujita M,Igoshin OA

更新日期：2016-12-01 00:00:00

abstract：:Complete and long-lasting protective immunity against malaria can be achieved through vaccination with invasive live attenuated Plasmodium sporozoites, the motile stage inoculated in the host skin during a mosquito bite. Protective immunity relies primarily on effector CD8+ T cells targeting the parasite in the liver....

journal_title：Current opinion in microbiology

authors： Silvie O,Amino R,Hafalla JC

更新日期：2017-12-01 00:00:00

abstract：:It is well accepted that bacterial pathogens growing in a biofilm are recalcitrant to the action of most antibiotics and are resistant to the innate immune system. New treatment modalities are greatly warranted to effectively eradicate these infections. However, bacteria growing in a biofilm are metabolically unique i...

journal_title：Current opinion in microbiology

authors： Fey PD

更新日期：2010-10-01 00:00:00

abstract：:Virulence associated protein type III secretion systems (T3SSs) are intricately structured organic nanosyringes that achieve the translocation of bacterial proteins from the prokaryotic cytoplasm across three membranes into the host cytosol. The substrates for these systems number in the hundreds, with remarkably dive...

journal_title：Current opinion in microbiology

authors： Marlovits TC,Stebbins CE

更新日期：2010-02-01 00:00:00

abstract：:The ability to control uptake across the mucosa and to protect the gut from harmful substances present in the lumen is defined as intestinal barrier function. Two routes are usually distinguished for transepithelial transport. The paracellular route allows the passage of ions and small molecules and is mainly regulate...

journal_title：Current opinion in microbiology

authors： Barreau F,Hugot JP

更新日期：2014-02-01 00:00:00

abstract：:The ongoing development of metagenomic approaches is providing the means to explore antibiotic resistance in nature and address questions that could not be answered previously with conventional culture-based strategies. The number of available environmental metagenomic sequence datasets is rapidly expanding and hencef...

journal_title：Current opinion in microbiology

authors： Monier JM,Demanèche S,Delmont TO,Mathieu A,Vogel TM,Simonet P

更新日期：2011-06-01 00:00:00

abstract：:Upon infection, both DNA and RNA viruses can be sensed by pattern recognition receptors (PRRs) in the cytoplasm or the nucleus to activate antiviral innate immunity. Sensing of viral products leads to the activation of a signaling cascade that ultimately results in transcriptional activation of type I and III interfer...

journal_title：Current opinion in microbiology

authors： Beachboard DC,Horner SM

更新日期：2016-08-01 00:00:00

abstract：:Staphylococcus aureus is a leading cause of hospital-acquired and often persistent infections. A key feature of pathogenic S. aureus is the expression of an array of extracellular matrix-binding proteins. In particular, the fibronectin-binding proteins FnBP-A and FnBP-B afford the pathogen the ability to connect to ce...

journal_title：Current opinion in microbiology

authors： Hauck CR,Ohlsen K

更新日期：2006-02-01 00:00:00

abstract：:Extracytoplasmic function σ factors (ECFs) represent a fundamental and widely distributed principle of bacterial signal transduction that connects the perception of a stimulus (input) with the induction of an appropriate set of genes (output). In recent years, comparative genomics analyses have not only allowed a syst...

journal_title：Current opinion in microbiology

authors： Mascher T

更新日期：2013-04-01 00:00:00

abstract：:Metagenomics is a novel field which deals with the sequencing and study of microbial organisms or viruses isolated directly from a particular environment. This has already provided a wealth of information and new insights for the inhabitants of various environmental niches. For a given sample, one would like to determ...

journal_title：Current opinion in microbiology

authors： McHardy AC,Rigoutsos I

更新日期：2007-10-01 00:00:00

abstract：:Virulence gene regulators RovA, SlyA and PecS comprise a subset of the MarR/SlyA family of transcriptional regulators, which has been shown to be involved in the regulation of virulence genes. These regulators have all been shown to both positively and negatively regulate the expression of multiple genes, involving se...

journal_title：Current opinion in microbiology

authors： Ellison DW,Miller VL

更新日期：2006-04-01 00:00:00

abstract：:One current challenge in metabolic systems biology is to map out the regulation networks that control metabolism. From progress in this area, we conclude that non-transcriptional mechanisms (e.g. metabolite-protein interactions and protein phosphorylation) are highly relevant in actually controlling metabolic function...

journal_title：Current opinion in microbiology

authors： Heinemann M,Sauer U

更新日期：2010-06-01 00:00:00

abstract：:Integrative and conjugative elements (ICEs) are nearly ubiquitous in microbial genomes and influence their evolution by providing adaptive functions to their host and by enhancing genome plasticity and diversification. For a long-time, it has been assumed that by integrating into the chromosome of their host, these se...

journal_title：Current opinion in microbiology

authors： Burrus V

更新日期：2017-08-01 00:00:00

abstract：:In response to starvation, myxobacteria build multicellular fruiting bodies that contain many thousands of cells and that have particular species-specific shapes. To coordinate fruiting body development, the myxobacterial cells signal to each other. The timing of and cellular responses to these signals help to give fo...

journal_title：Current opinion in microbiology

authors： Kaiser D

更新日期：1998-12-01 00:00:00

abstract：:Viruses attach to specific receptors, but identified receptors are often absent from the epithelial surfaces where infections begin. Viruses can bind to alternative receptor molecules present on epithelial surfaces and they can enter hosts in ways that bypass mucosal barriers to infection. To understand how viruses cr...

journal_title：Current opinion in microbiology

authors： Bergelson JM

更新日期：2003-08-01 00:00:00

abstract：:Trypanosomes and Leishmania contain an abundance of stage-regulated cysteine proteinases encoded by several gene families. Analysis of parasites rendered defective in cysteine proteinase function, either through genetic manipulation or through the use of specific inhibitors, has revealed roles for the enzymes in paras...

journal_title：Current opinion in microbiology

authors： Mottram JC,Brooks DR,Coombs GH

更新日期：1998-08-01 00:00:00

abstract：:Haloalkaliphiles are double extremophilic organisms thriving both at high salinity and alkaline pH. Although numerous haloalkaliphilic representatives have been identified among Archaea and Bacteria over the past 15 years, the adaptations underlying their prosperity at haloalkaline conditions are scarcely known. A mul...

journal_title：Current opinion in microbiology

authors： Banciu HL,Muntyan MS

更新日期：2015-06-01 00:00:00