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Probucol ameliorates hepatic stellate cell activation and autophagy is associated with farnesoid X receptor.

Abstract：

:Probucol has antioxidant effects and inhibits inflammation. Farnesoid X receptor (FXR) is a nuclear receptor that regulates autophagy, which is regarded as the key cause of the activation of hepatic stellate cell (HSC). In this study, the effects of probucol on HSC activation and autophagy in vitro and vivo and the role of FXR in this progress were investigated. Results showed that probucol ameliorated hepatic fibrosis and autophagy, and increased the expression of FXR in liver in a mouse model of fibrosis induced by CCl4. And probucol could alleviate lipopolysaccharide-induced autophagy and HSC activation in vitro. In addition, probucol increased FXR expression, and the Z-guggulsterone, an antagonist of FXR, could block the effects of probucol on HSC activation and autophagy. Additionally, agonists of FXR could suppress LPS-induced autophagy and activation. These results suggest that probucol could ameliorate hepatic fibrosis, and inhibit HSC autophagy and activation, and these effects are associated with FXR.

journal_name

J Pharmacol Sci

journal_title

Journal of pharmacological sciences

authors

Yang R,Hu Z,Zhang P,Wu S,Song Z,Shen X,Wei Z

doi

10.1016/j.jphs.2018.12.005

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

120-128

issue

2

eissn

1347-8613

issn

1347-8648

pii

S1347-8613(18)30228-7

journal_volume

139

pub_type

杂志文章

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