Involvement of the persistent Na+ current in the diastolic depolarization and automaticity of the guinea pig pulmonary vein myocardium.

abstract：:The maladaptive response of aged microglia to surgery and consequent neuroinflammation plays a key pathogenic role in postoperative cognitive dysfunction (POCD). Here, we assessed the preventive effect of resveratrol (RESV) for POCD in aged rats. The emulsified form of RESV (e-RESV) was selected to improve its oral an...

journal_title：Journal of pharmacological sciences

authors： Locatelli FM,Kawano T,Iwata H,Aoyama B,Eguchi S,Nishigaki A,Yamanaka D,Tateiwa H,Shigematsu-Locatelli M,Yokoyama M

更新日期：2018-08-01 00:00:00

abstract：:The role of nitric oxide (NO) on intestinal mucosal injury induced by single or consecutive administration of methotrexate was investigated in a rodent model. Rats received methotrexate intraperitoneally either as a single administration (50 mg/kg) or as a consecutive administration (12.5 mg/kg/day) for 4 days. NG-nit...

journal_title：Journal of pharmacological sciences

authors： Shiga S,Machida T,Yanada T,Machida M,Hirafuji M,Iizuka K

更新日期：2020-05-01 00:00:00

abstract：:We examined the effects of a cannabinoid receptor agonist, (R)-(+)-[2,3-dihydro-5-methyl-3-[(4-merpholino)methyl]pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl](1-naphthyl)methanone (WIN 55212-2), on various respiratory reactions induced by the activation of capsaicin-sensitive afferent sensory nerves (C-fibers). WIN 55212-2 ...

journal_title：Journal of pharmacological sciences

authors： Yoshihara S,Morimoto H,Ohori M,Yamada Y,Abe T,Arisaka O

更新日期：2005-05-01 00:00:00

abstract：:Oleoylethanolamine (OEA), an endogenous high-affinity agonist of peroxisome proliferator-activated receptor alpha (PPAR-α), has revealed the pharmacological properties in the treatment of obesity, atherosclerosis and other diseases through the modulation of lipid metabolism. To assess whether OEA can also regulate non...

journal_title：Journal of pharmacological sciences

authors： Li L,Li L,Chen L,Lin X,Xu Y,Ren J,Fu J,Qiu Y

更新日期：2015-03-01 00:00:00

abstract：:Incomplete recovery of myocardial contraction after reperfusion following brief ischemia is called the "stunning phenomenon" in an animal experiment. A hydrophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin) does not affect this phenomenon, but lipophilic statins further reduce the con...

journal_title：Journal of pharmacological sciences

authors： Satoh K,Takaguri A,Itagaki M,Kano S,Ichihara K

更新日期：2008-04-01 00:00:00

abstract：:Sargassum hemiphyllum (SH) has long been used in Korean folk medicine for the therapeutic treatment of various allergic diseases. The effects of SH in previous experimental models, however, have been inconclusive. We studied the effects of methanol extract of SH on mast cells. Our experiments showed that SH significan...

journal_title：Journal of pharmacological sciences

authors： Na HJ,Moon PD,Ko SG,Lee HJ,Jung HA,Hong SH,Seo Y,Oh JM,Lee BH,Choi BW,Kim HM

更新日期：2005-02-01 00:00:00

abstract：:We investigated the effects of treatment with trimethyltin (TMT) on the expression of glutathione-related enzymes in mouse hippocampus. TMT promoted the expression of glutathione S-transferase (GST) Ya/Yc mRNA, and GSTA2 protein, but not that of glutamate-cysteine ligase catalytic subunit mRNA, 1 day after injection. ...

journal_title：Journal of pharmacological sciences

authors： Nagashima R,Sano S,Huong NQ,Shiba T,Ogita K

更新日期：2010-01-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) and dioxins are ubiquitous environmental pollutants and activate the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor. It has been reported that testosterone represses 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced transcription of the cytochrome P450 (CYP) ...

journal_title：Journal of pharmacological sciences

authors： Sanada N,Gotoh Y,Shimazawa R,Klinge CM,Kizu R

更新日期：2009-03-01 00:00:00

abstract：:Simultaneous administration of psychostimulants and opioids is a major drug abuse problem worldwide. This combination appears to produce synergistic effects on behavior at low doses; however, there is little direct evidence that the combination is stronger than either drug alone. Therefore, we investigated interaction...

journal_title：Journal of pharmacological sciences

authors： Mori T,Ito S,Narita M,Suzuki T,Sawaguchi T

更新日期：2004-12-01 00:00:00

abstract：:Fullerene (C(60)), a condensed ring aromatic compound with extended pi systems, is a novel carbon allotrope. Because of its poor solubility in polar solvents, investigation of the biological and pharmacological properties of fullerene has been difficult. Recently, water-soluble fullerene derivatives have been synthesi...

journal_title：Journal of pharmacological sciences

authors： Satoh M,Takayanagi I

更新日期：2006-01-01 00:00:00

abstract：:Antipsychotics are often used in conjunction with anti-Alzheimer drugs to treat the behavioral and psychological symptoms of dementia (BPSD). Here, we examined the effects of cholinesterase inhibitors (ChEIs), donepezil and galantamine, on antipsychotic-induced extrapyramidal side effects (EPS) in mice. The effects of...

journal_title：Journal of pharmacological sciences

authors： Shimizu S,Mizuguchi Y,Sobue A,Fujiwara M,Morimoto T,Ohno Y

更新日期：2015-04-01 00:00:00

abstract：:The purpose of the current study was to explore the effects of N-methyl-D-aspartate (NMDA)-receptor antagonists (MK-801 and LY235959) administered intracerebroventricularly on the changes of both core temperature and hypothalamic levels of 2,3-dihydroxybenzoic acid (2,3-DHBA) induced by intracerebroventricular injecti...

journal_title：Journal of pharmacological sciences

authors： Kao CH,Kao TY,Huang WT,Lin MT

更新日期：2007-06-01 00:00:00

abstract：:The biological basis for the therapeutic mechanisms of depression are still unknown. While performing EST (expressed sequence tag) analysis to identify some molecular machinery responsible for the antidepressant effect, we determined the full-length nucleotide sequence of rat frizzled-3 protein (Frz3) cDNA. Interestin...

journal_title：Journal of pharmacological sciences

authors： Yamada M,Iwabuchi T,Takahashi K,Kurahashi C,Ohata H,Honda K,Higuchi T,Yamada M

更新日期：2005-11-01 00:00:00

abstract：:Kv1.5 is considered to be a potential molecular target for treatment of atrial fibrillation or flutter. Disopyramide is widely used in the treatment of atrial flutter and/or atrial fibrillation. The present study was undertaken to characterize the effects of disopyramide on currents mediated by Kv1.5 channels and to d...

journal_title：Journal of pharmacological sciences

authors： Aréchiga IA,Barrio-Echavarria GF,Rodríguez-Menchaca AA,Moreno-Galindo EG,Decher N,Tristani-Firouzi M,Sánchez-Chapula JA,Navarro-Polanco RA

更新日期：2008-09-01 00:00:00

abstract：:The pharmacological mechanisms of a synthetic compound 1-benzyl-3-(5'-hydroxymethyl-2'-furyl) indazole (YC-1) in preventing smooth muscle cell proliferation remains to be elucidated. The present study was aimed to explore the effects of YC-1 on certain molecules responsible for cell proliferation, including transformi...

journal_title：Journal of pharmacological sciences

authors： Wu CH,Chang WC,Chang GY,Kuo SC,Teng CM

更新日期：2004-03-01 00:00:00

abstract：:We prepared a colon cancer-bearing Yoshida sarcoma rat model to examine the dose-response relationship of antitumor activity of intracolonically or orally administered 5-fluorouracil (5-FU; 45, 30, 20, 13, and 8 mg/kg). At doses of > or =20 mg/kg and > or =30 mg/kg, the 5-FU intracolonic and oral administration groups...

journal_title：Journal of pharmacological sciences

authors： Goto T,Tomizawa N,Kobayashi E,Fujimura A

更新日期：2004-06-01 00:00:00

abstract：:Metabolic syndrome (MetS) induces serious complications; therefore, we developed a noninvasive MetS model using an extremely small minipig, the Microminipig. For 8 weeks, Microminipigs were administrated a high-fat and high-cholesterol diet (HFCD) for atherosclerosis and N(G)-nitro-l-arginine methyl ester (l-NAME) for...

journal_title：Journal of pharmacological sciences

authors： Yamaguchi T,Yamazaki T,Kawaguchi H,Tawa M,Nakamura Y,Shiota M,Osada-Oka M,Tanimoto A,Okamura T,Miura K,Iwao H,Yoshiyama M,Izumi Y

更新日期：2014-01-01 00:00:00

abstract：:In the present study, we investigated whether a novel benzopyranylindol analogue, KR-31466 (KR466) (1-[(2S,3R,4S)-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-6-nitro-2H-1-benzopyran-4-yl]-1H-indole-2-carboxylic acid ethyl ester) can attenuate hypoxic injury in heart-derived H9c2 cells and, if so, whether the prot...

journal_title：Journal of pharmacological sciences

authors： Jung YS,Jung YS,Kim MY,Kim MH,Lee S,Yi KY,Yoo SE,Lee SH,Baik EJ,Moon CH,Cho JP

更新日期：2003-05-01 00:00:00

abstract：:Cytochrome P450 (CYP) catalyzes the oxidation of many endogenous and xenobiotic compounds. The expression of CYP isozymes are modulated by endogenous hormones and xenobiotics. We found that, although CYP2C11 and CYP3A2 are adult male-specific isozymes, they are also expressed in prepubertal female Sprague Dawley (SD) ...

journal_title：Journal of pharmacological sciences

authors： Ishii T,Nishimura K,Nishimura M

更新日期：2006-07-01 00:00:00

abstract：:Photodynamic therapy (PDT) is an evolving cancer treatment with promising results in treating malignant tumors by photoactivation of a photosensitizer with a specific wavelength. The second generation photosensitizer mono-L-aspartyl chlorin e6 (NPe6) was reported to have significant efficacy in killing cancer cells in...

journal_title：Journal of pharmacological sciences

authors： Wong TW,Aizawa K,Sheyhedin I,Wushur C,Kato H

更新日期：2003-10-01 00:00:00

abstract：:Multi-glycoside, one of the extracted compounds from Tripterygium wilfordii HOOK. f. (GTW), has been shown to be clinically effective in suppressing glomerular inflammation in chronic kidney disease. However, its clinical application is often limited by its cytotoxic actions on the liver. This study was performed to c...

journal_title：Journal of pharmacological sciences

authors： Wan YG,Zhao Q,Sun W,Zhang HL,Li M,Wei QX,Wu W,Yue LJ,Wang Q

更新日期：2012-01-01 00:00:00

abstract：:The GABAergic system in the spinal cord has been shown to participate in neuropathic pain in various animal models. GABA transporters (GATs) play a role in controlling the synaptic clearance of GABA; however, their role in neuropathic pain remains unclear. In the present study, we compared the betaine/GABA transporter...

journal_title：Journal of pharmacological sciences

authors： Jinzenji A,Sogawa C,Miyawaki T,Wen XF,Yi D,Ohyama K,Kitayama S,Sogawa N,Morita K

更新日期：2014-01-01 00:00:00

abstract：:The hepatitis C virus (HCV) is an enveloped virus with a single positive-strand RNA genome of about 9.6 kb. It is a major cause of liver disease worldwide. Clear understanding of the viral life cycle has been hampered by the lack of a robust cell culture system. While the development of the HCV replicon system was a m...

journal_title：Journal of pharmacological sciences

authors： Saito S,Heller T,Yoneda M,Takahashi H,Nakajima A,Liang JT

更新日期：2007-10-01 00:00:00

abstract：:To examine effects of volatile anesthetics (VAs) on steroidogenesis, cell suspensions of isolated bovine adrenocortical cells were incubated with several steroidogenic agents in the presence or absence of halothane and sevoflurane. The adrenocortical cells were dispersed by trypsin digestion of bovine adrenal cortex. ...

journal_title：Journal of pharmacological sciences

authors： Masaki E,Shoji K,Saito H,Yamazaki K,Kawamura M

更新日期：2003-10-01 00:00:00

abstract：:Selegiline is used an adjunct to L-DOPA therapy. We investigated extracellular striatal dopamine (DA) level in awake rats treated with L-DOPA and/or selegiline using a microdialysis method. Rats given 10 mg/kg, i.p. per day selegiline for 7 days were administered with a single dose of 100 mg/kg, i.p. L-DOPA 0 (3 h), 1...

journal_title：Journal of pharmacological sciences

authors： Adachi K,Miwa H,Kusumoto H,Shimazu S,Kondo T

更新日期：2006-08-01 00:00:00

abstract：:Dopamine (DA) has been suggested to modulate functions of glial cells including microglial cells. To reveal the regulatory role of DA in microglial function, in the present study, we investigated the effect of DA on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in murine microglial cell line BV-2. Pret...

journal_title：Journal of pharmacological sciences

authors： Yoshioka Y,Sugino Y,Tozawa A,Yamamuro A,Kasai A,Ishimaru Y,Maeda S

更新日期：2016-02-01 00:00:00

abstract：:We investigated the roles of β- and α(2)-adrenoceptors within the central nucleus of the amygdala (CeA) in the negative affective and sensory components of visceral pain in rats. We observed a dose-dependent reduction of intraperitoneal acetic acid-induced conditioned place aversion by bilateral injections of timolol,...

journal_title：Journal of pharmacological sciences

authors： Deyama S,Takishita A,Tanimoto S,Ide S,Nakagawa T,Satoh M,Minami M

更新日期：2010-01-01 00:00:00

abstract：:Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice. Plasma exudation was assessed by extravasation of Evans blue. Subcutaneous administration of LPA...

journal_title：Journal of pharmacological sciences

authors： Hashimoto T,Ohata H,Honda K

更新日期：2006-01-01 00:00:00

abstract：:IAP antagonists increased the antitumor efficacy of X-irradiation in some types of cancers, but their effects on hypoxic cancer cells remain unclarified. We aims to investigate the radiosensitizing effect of an IAP inhibitor AT-406 on cervical cancer cell lines under both normoxia and hypoxia conditions. Hela and Siha...

journal_title：Journal of pharmacological sciences

authors： Lu J,Qin Q,Zhan LL,Liu J,Zhu HC,Yang X,Zhang C,Xu LP,Liu ZM,Wang D,Cui HQ,Meng CC,Cai J,Cheng HY,Sun XC

更新日期：2014-01-01 00:00:00

abstract：:Heat shock protein 90 (HSP90) antagonists are currently being evaluated as potential anticancer drugs. However, adverse effects related to these drugs, such as fatigue and pain, suggest that they affect neurons. Therefore, to understand the influence of HSP90 inhibitors on neurons, we investigated the effects of gelda...

journal_title：Journal of pharmacological sciences

authors： Migita K,Matsumoto T,Terada K,Ono K,Hara S

更新日期：2019-07-01 00:00:00