Abstract:
:We investigated the roles of β- and α(2)-adrenoceptors within the central nucleus of the amygdala (CeA) in the negative affective and sensory components of visceral pain in rats. We observed a dose-dependent reduction of intraperitoneal acetic acid-induced conditioned place aversion by bilateral injections of timolol, a β-adrenoceptor antagonist, or clonidine, an α(2)-adrenoceptor agonist, without reducing writhing behaviors. These data suggest a pivotal role of intra-CeA adrenoceptors in the negative affective, but not sensory, component of visceral pain.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Deyama S,Takishita A,Tanimoto S,Ide S,Nakagawa T,Satoh M,Minami Mdoi
10.1254/jphs.10139scsubject
Has Abstractpub_date
2010-01-01 00:00:00pages
123-6issue
1eissn
1347-8613issn
1347-8648pii
JST.JSTAGE/jphs/10139SCjournal_volume
114pub_type
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