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Noninvasive metabolic syndrome model using an extremely small minipig, the microminipig.

Abstract：

:Metabolic syndrome (MetS) induces serious complications; therefore, we developed a noninvasive MetS model using an extremely small minipig, the Microminipig. For 8 weeks, Microminipigs were administrated a high-fat and high-cholesterol diet (HFCD) for atherosclerosis and N(G)-nitro-l-arginine methyl ester (l-NAME) for inhibiting nitric oxide synthase. HFCD significantly increased serum low-density lipoprotein levels, l-NAME increased blood pressure and cardiac hypertrophy, and HFCD-induced aortal arteriosclerosis was accelerated by l-NAME administration. Endothelium-dependent relaxation of the coronary artery was remarkably decreased by l-NAME administration. This model may be useful for elucidating the mechanisms of MetS and developing new therapeutic medicines for its treatment.

journal_name

J Pharmacol Sci

journal_title

Journal of pharmacological sciences

authors

Yamaguchi T,Yamazaki T,Kawaguchi H,Tawa M,Nakamura Y,Shiota M,Osada-Oka M,Tanimoto A,Okamura T,Miura K,Iwao H,Yoshiyama M,Izumi Y

doi

10.1254/jphs.14171sc

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

168-71

issue

2

eissn

1347-8613

issn

1347-8648

pii

DN/JST.JSTAGE/jphs/14171SC

journal_volume

126

pub_type

杂志文章

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